Assessment of Ropivacaine as a Local Anesthetic for Skin Infiltration in Skin Surgery

Moffitt, D. L.; Berker, Dilek; KENNEDY, CAMERON T.K.; Shutt, L.E.

doi:10.1097/00042728-200105000-00003

Cited by 9 publications

(13 citation statements)

References 6 publications

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“…18 This may be clinically relevant in skin surgery. 19 In our study 0.375% bupivacaine, a higher concentration than that used by Biswas and Bithal 3 and by Bloomfield et al, 4 was compared with 0.75% ropivacaine. Because it has been reported that wound infiltration with bupivacaine 100 mg is as effective as with ropivacaine 300 mg Values are number of patients (n) or percentages (%).…”

Section: Discussionmentioning

confidence: 56%

Scalp Infiltration with Bupivacaine Plus Epinephrine or Plain Ropivacaine Reduces Postoperative Pain After Supratentorial Craniotomy

Law-Koune

Szekély²,

Fermanian³

et al. 2005

Journal of Neurosurgical Anesthesiology

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Local anesthetic infiltration has been proposed to decrease postoperative pain. The aim of this study was to determine whether scalp infiltration with bupivacaine or ropivacaine would improve analgesia after supratentorial craniotomy for tumor resection. Eighty patients were recruited into a randomized double-blind study. Infiltration was performed after skin closure with 20 mL of saline 0.9% (placebo group, n = 40), of 0.375% bupivacaine with epinephrine 1:200,000 (bupivacaine group, n = 20), or of 0.75% ropivacaine (ropivacaine group, n = 20). Postoperative analgesia was provided with patient-controlled morphine IV analgesia (PCA). The study was continued until PACU discharge, which occurred early in the morning following surgery. Results are reported on 37 patients in the placebo group, 20 in the bupivacaine group, and 19 in the ropivacaine group because 4 patients experienced postoperative complications and were excluded from the study. Morphine titration at arrival in the postanesthesia care unit was necessary more often in the placebo group (62% of the patients) than in the 2 treated groups (19% in each, P = 0.02). The median quantity of morphine administered during the first 2 postoperative hours, including initial titration administered by a nurse and PCA-administered morphine, was lower in each treated group than in the placebo group (P < 0.01). The median morphine consumption up to the 16th postoperative hour was not significantly different among the 3 groups. There was no difference in the visual analogue scale scores among the 3 groups at any time. Scalp infiltration with either bupivacaine or ropivacaine had a statistically significant effect on morphine consumption during the first 2 postoperative hours.

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Section: Discussionmentioning

confidence: 56%

Scalp Infiltration with Bupivacaine Plus Epinephrine or Plain Ropivacaine Reduces Postoperative Pain After Supratentorial Craniotomy

Law-Koune

Szekély²,

Fermanian³

et al. 2005

Journal of Neurosurgical Anesthesiology

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“…Since mechanisms of vasoactive effect of ropivacaine are not so clear, it was pointed out that ropivacaine causes vasoconstriction or not intensive vasodilation in animals [41] and after the human skin infiltration [42]. Although formerly demonstrated successful maxillary infiltration anesthesia for upper third molar surgery indirectly confirms local vasoconstriction of 0.75 and 1 % ropivacaine in absence of the added vasoconstrictor, Brkovic et al [23] showed in the in vitro experiment significant increase of the basal arterial tone of isolated human infraorbital arteries.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study

et al. 2016

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“…Hence ropivacaine for episiotomy infiltration has been chosen for the research with commonly used lidocaine. Moffitt DL et al 24 in his double blind study compared four concentrations of ropivacaine (1, 2, 5 and 7.5 mg/mL) with normal saline for skin infiltration in skin surgery, and additionally compared with lidocaine 2%+ epinephrine 1:80,000. The results were similar to our study that ropivacaine has a rapid onset and long duration of action.…”

Section: Discussionmentioning

confidence: 99%

Ropivacaine Versus Lidocaine for Episiotomy-a Randomised Double Blind Study

Nagaraj¹,

Thalamkandathil²,

Sadique³

2017

jebmh

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BACKGROUND Episiotomy is a most common surgical procedure for parturients during vaginal delivery. The problem encountered with episiotomy is pain, which is maximum during first 24 hours and may be severe enough to disturb the puerperium. This study aims to compare analgesic efficacy of analgesics, ropivacaine and lidocaine for perineal infiltration during episiotomy. MATERIALS AND METHODS We conducted a randomised double blind study for a period one year from August 2013 in a tertiary hospital. 100 parturients were included. RESULTS Ropivacaine 0.75% compared to lidocaine 2% did not show any statistical significant changes at suturing and after 4 hours; however, there were great statistically significant changes in VAS scores after 8 hours, 12 hours, 24 hours of episiotomy suturing. Ropivacaine group did not require systemic analgesics for 24 hours, but lidocaine group required systemic analgesics after 4 hours of suturing. Both groups (Ropivacaine and Lidocaine) did not have any adverse effects. CONCLUSION Ropivacaine can be used safely for episiotomy wound infiltration thereby reducing the need for systemic analgesia.

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Assessment of Ropivacaine as a Local Anesthetic for Skin Infiltration in Skin Surgery

Cited by 9 publications

References 6 publications

Scalp Infiltration with Bupivacaine Plus Epinephrine or Plain Ropivacaine Reduces Postoperative Pain After Supratentorial Craniotomy

Scalp Infiltration with Bupivacaine Plus Epinephrine or Plain Ropivacaine Reduces Postoperative Pain After Supratentorial Craniotomy

Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study

Ropivacaine Versus Lidocaine for Episiotomy-a Randomised Double Blind Study

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