Assessment of salivary total antioxidant levels and oral health status in children with Down syndrome

Subramaniam, Priya; Babu, KL Girish; Das, Lakshmi

doi:10.1111/scd.12054

Cited by 23 publications

(36 citation statements)

References 54 publications

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“…The studies were from India [25], Jordan [17], Portugal [6,14,15], Brazil [24], Turkey [11,31], the USA [32,33], China [13], Nigeria [20] and the Republic of Korea [34]. Although they presented different results, the studies by Areias (2011; 2012) used the same sample group [14,15].…”

Section: Resultsmentioning

confidence: 99%

“…The articles were sorted into two groups in accordance with the description of the authors. Six studies assessed dental caries in permanent teeth, with the mean DMFT index (Decayed, Missing, and Filled Teeth) being the dependent variable analyzed [13,15,17,20,24,25]. Two studies considered all teeth (deciduous and permanent) and used a categorical dependent variable (presence or absence of dental caries) [6,14,15].…”

Section: Methodsmentioning

confidence: 99%

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Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis

et al. 2015

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Scientific evidence of susceptibility to dental caries in the population with Down Syndrome (DS) is limited and conflicting, making it difficult to establish firm conclusions. The aim of this systematic review and meta-analysis was to obtain scientific evidence of the possible association between dental caries and individuals with DS, compared to individuals without DS (control). An electronic search of five databases was performed, with no language or publication date restrictions. The studies were selected by two independent reviewers (Kappa = 0.83). The systematic review included 13 studies, while eight studies were included in the meta-analysis. The studies are presumably all at risk of bias given their observational character. Two of these evaluated the presence or absence of caries in permanent and deciduous teeth, and six evaluated the mean DMFT index in permanent teeth. Combined odds ratios (OR), standard difference, standard error and a 95% confidence interval (CI) were obtained. The vast majority of the studies found that individuals from control groups had more carious lesions or caries experience than those with DS. The results were statistically significant in seven studies (p<0.05). Meta-analysis of two studies revealed that individuals with DS had a lower dental caries than those in the control group (OR = 0.36; 95% CI = 0.22–0.57). In six studies, individuals with DS had a significantly lower mean DMFT index than individuals from the control group (Sd = -0.18; SE = 0.09; 95% CI = -0.35–-0.02). The quality of the studies varied and in general had a high risk of bias. Scientific evidence suggests that individuals with DS have fewer dental caries than individuals without DS.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis

et al. 2015

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“…These findings are not consistent with others studies that found a significantly lower total antioxidant capacity in children with DS when compared to control. [45][46][47] In conclusion, saliva is an important tool for primary diagnosis of a possible systemic oxidative stress in patients with Down's syndrome. The present results showed a significant increase in salivary SOD concentration, MDA levels and total protein content in these patients.…”

Section: Discussionmentioning

confidence: 99%

Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome

Sousa¹,

Vieira²,

Santos³

et al. 2015

Archives of Oral Biology

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“…[14] This is consistent with many previous studies which reported poorer standard of oral hygiene and greater prevalence of periodontal diseases in DS children than their normal counterparts. [512151617181920] A multitude of factors may be involved in the increased susceptibility to gingival and periodontal diseases among individuals with DS. [21] Factors previously investigated include mental retardation, subgingival plaque composition, immune/inflammatory responses, and others.…”

Section: Discussionmentioning

confidence: 99%

“…[21] Factors previously investigated include mental retardation, subgingival plaque composition, immune/inflammatory responses, and others. [202122] Microbiological studies showed that individuals with DS have significantly higher levels of periodontopathic bacteria including Porphyromonas gingivalis and Tannerella forsythensis . [17] Hence, optimal oral hygiene is of particular importance in this group in order to limit the disease onset.…”

Section: Discussionmentioning

confidence: 99%

Oral hygiene and gingival health status of children with Down syndrome in Yemen: A cross-sectional study

Al-Sufyani¹,

Al‐Maweri²,

Al-Ghashm³

et al. 2014

J Int Soc Prevent Communit Dent

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Purpose:The objective of the present study was to assess the oral hygiene and gingival health status among Yemeni children with Down syndrome.Materials and Methods:The study sample comprised 101 children with Down syndrome attending special needs schools in Sana’a, Yemen. The calculus index (CI), plaque index (PI), and the gingival index (GI) were used to assess oral hygiene and gingival health status.Results:All subjects had gingivitis; the mean CI, PI, and GI scores were 0.58 ± 0.61, 1.45 ± 0.57, and 1.54 ± 0.64, respectively, with no significant difference found across gender. Stepwise linear regression analysis revealed that the best predictors in the descending order for CI were age and mother's education, and the best predictors for PI were IQ level, age, and father's education. Having severe mental retardation, older age, less educated parents were the most important predictors for poor gingival health status.Conclusions:These findings show that children with Down syndrome have poor oral hygiene and high levels of periodontal diseases. Hence, appropriate oral health education should be tailored to the needs of these children with the support of their teachers and parents.

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Assessment of salivary total antioxidant levels and oral health status in children with Down syndrome

Abstract: In comparison to normal children, DS children showed significantly lower TAC of saliva and significantly higher salivary SA levels. In both groups of children, dental caries was higher in primary dentition when compared to their permanent dentition.

Cited by 23 publications

References 54 publications

Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis

Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis

Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome

Oral hygiene and gingival health status of children with Down syndrome in Yemen: A cross-sectional study

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