Assessment of Secondary Sarcomas Among Patients With Cancer of the Abdomen or Pelvis Who Received Combinations of Surgery, Radiation, and Chemotherapy vs Surgery Alone

Hird, Amanda; Magee, Diana; Matta, Rano; Saskin, Refik; Dvorani, Erind; Kulkarni, Girish S.; Kodama, Ronald; Herschorn, Sender; Narod, Steven A.; Nam, Robert K.

doi:10.1001/jamanetworkopen.2020.13929

Cited by 6 publications

(5 citation statements)

References 38 publications

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“…Identifying reliable biomarkers for predicting the clinical response to immunotherapy in different malignancies has become an urgent requirement; several studies have demonstrated that chemotherapy and radiotherapy could elevate the incidence of second primary malignancy. [ 9 , 10 ] However, the relationships of immunotherapy with long-term and short-term second primary malignancy incidence are still unclear and require further long-term investigation. Regarding the treatment, we suggested NGS to both patients, but neither accepted the suggestion.…”

Section: Discussionmentioning

confidence: 99%

Second primary malignancy post immunotherapy: A case report of 2 cases

Miao,

Dong,

Tao

et al. 2024

Medicine

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Rationale: Immune checkpoint inhibitors have shown high efficacies as the first-line treatment of various advanced malignancies. Yet, the effect and practice patterns of immune checkpoint inhibitors on the second primary tumors are still unclear. Second primary malignancy post immunotherapy, there is paucity in such cases being reported. Patient concerns: We report 2 cases of a 57-year-old woman with nonsmall cell lung cancer and a 69-year-old man with metastatic clear cell renal carcinoma treated with immunotherapy who developed second primary malignancies during the therapy. Diagnosis: Second primary malignancy during the therapy. Interventions: In addition to the treatments of the second primary malignancies, maintenance immunotherapy was continued for the patients. Outcomes: Overall survival in both patients was longer than 12 months, and the treatments were well tolerated. The adverse reactions mainly included depigmentation of hair and facial and limb skin in patient 1 and diarrhea in patient 2. Lessons: It is necessary to recognize that the second primary malignancy may occur during the immunotherapy, and more clinical studies and practices are still needed for the adjustment of the regimens of immunotherapy. Full diagnosis, timely treatment, and long-term regular follow-up have important significance for patients with malignancies.

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Section: Discussionmentioning

confidence: 99%

Second primary malignancy post immunotherapy: A case report of 2 cases

Miao,

Dong,

Tao

et al. 2024

Medicine

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“…Furthermore, while our case predominately examines a genitourinary radiation-induced secondary malignancy in a male patient, both genders are at risk. A cohort of men and women undergoing abdominopelvic radiation for primary colorectal or genitourinary cancers were found to have an incidence of 0.3% developing sarcomas after radiation [11]. In addition, age has been examined as a risk factor for radiation-induced secondary malignancy.…”

Section: Discussionmentioning

confidence: 99%

A Rare Primary Osteogenic Sarcoma of the Prostate and Bladder

Rockmore

McIntosh

Pui

et al. 2021

Cureus

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Mesenchymal tumors of the genitourinary tract account for 5% percent of bladder malignancies and there are currently 35 documented cases of osteosarcoma type. Concomitant involvement of the prostate in mesenchymal genitourinary malignancies is even rarer. Herein we describe a case of a 72-year-old male with a history of radiation for prostate cancer who develops hematuria. A hematuria evaluation revealed osteosarcoma of the bladder and prostate. He underwent radical cystoprostatectomy with ileal conduit and adjuvant chemotherapy. His disease progressed despite treatment and he elected palliative care 10 months after initial resection. This case reviews a rare histological variant of genitourinary malignancy.

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“…A review of rhabdomyolysis for clinical practice in AKI noted pathophysiologic similarities with tumor lysis syndrome (Chavez et al, 2016). Of relevance, the incidence of secondary sarcomas was higher in patients treated with radiation, surgery, and chemotherapy than with surgery alone, which could be related to dysregulated levels of phosphate released during tumor lysis from radiation and chemotherapy (Hird et al, 2020). A low‐phosphate diet in patients receiving radiation and chemotherapy might help mitigate the risk of phosphate toxicity from tumor lysis syndrome, but more studies are needed in this area.…”

Section: Alcohol and Rhabdomyolysismentioning

confidence: 99%

Breast cancer, alcohol, and phosphate toxicity

Brown

Bigelow

Dubin

et al. 2023

J of Applied Toxicology

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Alcohol consumption is associated with an increased risk of breast cancer, even at low alcohol intake levels, but public awareness of the breast cancer risk associated with alcohol intake is low. Furthermore, the causative mechanisms underlying alcohol's association with breast cancer are unknown. The present theoretical paper uses a modified grounded theory method to review the research literature and propose that alcohol's association with breast cancer is mediated by phosphate toxicity, the accumulation of excess inorganic phosphate in body tissue. Serum levels of inorganic phosphate are regulated through a network of hormones released from the bone, kidneys, parathyroid glands, and intestines. Alcohol burdens renal function, which may disturb the regulation of inorganic phosphate, impair phosphate excretion, and increase phosphate toxicity. In addition to causing cellular dehydration, alcohol is an etiologic factor in nontraumatic rhabdomyolysis, which ruptures cell membranes and releases inorganic phosphate into the serum, leading to hyperphosphatemia. Phosphate toxicity is also associated with tumorigenesis, as high levels of inorganic phosphate within the tumor microenvironment activate cell signaling pathways and promote cancer cell growth. Furthermore, phosphate toxicity potentially links cancer and kidney disease in onco‐nephrology. Insights into the mediating role of phosphate toxicity may lead to future research and interventions that raise public health awareness of breast cancer risk and alcohol consumption.

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Assessment of Secondary Sarcomas Among Patients With Cancer of the Abdomen or Pelvis Who Received Combinations of Surgery, Radiation, and Chemotherapy vs Surgery Alone

Cited by 6 publications

References 38 publications

Second primary malignancy post immunotherapy: A case report of 2 cases

Second primary malignancy post immunotherapy: A case report of 2 cases

A Rare Primary Osteogenic Sarcoma of the Prostate and Bladder

Breast cancer, alcohol, and phosphate toxicity

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