Assessment of Select Serum Cytokines TNF-a and Il-22 in Oral Lichen Planus Patients

Immunological abnormalities in lichen planus

“…Based on serum IL-22 concentration a relapse of lichen planus could be also proposed. During relapse of erosive LP, the level of IL-22 was found to 9 times increased compared to the control group [27]. Moreover, IL-22 can be used as a tool that helps to differentiate a chronic erosive and chronic non-erosive LP.…”

“…The concentration of this interleukin is higher in the saliva of people with lichen planus compared to controls [6,8]. The results of most studies indicate that plasma or saliva levels of IL-4 are higher in erosive forms than in reticular lichen planus [9,[26][27][28][29][30][31]. Moreover, the salivary concentration of IL-4 can be used as a biomarker of disease severity course [5,26].…”

“…Moreover, IL-22 can be used as a tool that helps to differentiate a chronic erosive and chronic non-erosive LP. Increased IL-22 suggests the presence of erosive LP, while in chronic non-erosive lichen planus a statistically significant (p < 0.05) decreased IL-22 level is observed [27]. Decreased IL-17 in combination with reduced IL-21 and IL-22 is considered a remission marker [35].…”

“…Stężenie tej interleukiny jest podwyższone w ślinie chorych z liszajem płaskim w porównaniu z grupą kontrolną [6,8]. Wyniki większości badań wskazują, że stężenie IL-4 w osoczu lub ślinie jest wyższe w postaci nadżerkowej niż siateczkowatej liszaja płaskiego [9,[26][27][28][29][30][31]. Stężenie IL-4 w ślinie może również służyć jako biomarker ciężkości przebiegu choroby [5,26].…”

“…Some studies revealed a significantly higher serum level of TNF compared to healthy controls [6,39]. Furthermore, an increased serum level of TNF in the case of erosive lichen planus can be used as a prognostic marker of relapse [27].…”