Assessment of selected Yemeni medicinal plants for their<i>in vitro</i>antimicrobial, anticancer, and antioxidant activities

Mothana, Ramzi A.; Kriegisch, S.; Harms, Manuela; Wende, Kristian; Lindequist, Ulrike

doi:10.3109/13880209.2010.512295

Cited by 82 publications

(55 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, MCF-7 cells were used in 2 additional studies and while both were found to inhibit cell proliferation, the IC50 values varied greatly from 187 µg/mL [31] to 9.95–13.89 µg/mL (RE standardized to 25%–43% CA) [18]. In agreement with the aforementioned studies, the RE resulting in a higher IC50 value was obtained from an alcohol based, methanol extraction [31]. …”

Section: Anticancer Effects Of Rosemary Extract (Re): In Vitro Stumentioning

confidence: 83%

“…There is a discrepancy seen in the reported IC50 values which may be attributed to the different extraction methods used for the preparation of rosemary extract; supercritical CO 2 [30] and ethanol extraction [29]. Furthermore, MCF-7 cells were used in 2 additional studies and while both were found to inhibit cell proliferation, the IC50 values varied greatly from 187 µg/mL [31] to 9.95–13.89 µg/mL (RE standardized to 25%–43% CA) [18]. In agreement with the aforementioned studies, the RE resulting in a higher IC50 value was obtained from an alcohol based, methanol extraction [31].…”

Section: Anticancer Effects Of Rosemary Extract (Re): In Vitro Stumentioning

confidence: 99%

See 1 more Smart Citation

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

2016

View full text Add to dashboard Cite

Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival. Compounds of plant origin, including food components, have attracted scientific attention for use as agents for cancer prevention and treatment. The exploration into natural products offers great opportunity to evaluate new anticancer agents as well as understand novel and potentially relevant mechanisms of action. Rosemary extract has been reported to have antioxidant, anti-inflammatory, antidiabetic and anticancer properties. Rosemary extract contains many polyphenols with carnosic acid and rosmarinic acid found in highest concentrations. The present review summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of rosemary extract and the rosemary extract polyphenols carnosic acid and rosmarinic acid, and their effects on key signaling molecules.

show abstract

Section: Anticancer Effects Of Rosemary Extract (Re): In Vitro Stumentioning

confidence: 83%

Section: Anticancer Effects Of Rosemary Extract (Re): In Vitro Stumentioning

confidence: 99%

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

2016

View full text Add to dashboard Cite

show abstract

“…Several methodologies have been applied with the aim of obtaining a high concentration of bioactive components from rosemary, including liquid (methanolic, ethanolic, aqueous, etc.) extractions as well as supercritical fluid extractions (5)(6)(7)(8)(9). Between them, the latter has been proposed as one of the most successful methods to extract the bioactive compounds of rosemary, since the antiproliferative activity of supercritical extracts was higher than that exerted by the extracts obtained by other methodologies (6,10,11).…”

Section: Antitumor Effects Of Rosemary Extractmentioning

confidence: 99%

Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy

González-Vallinas

Reglero

Molina

2015

Nutrition and Cancer

View full text Add to dashboard Cite

Cancer remains an important cause of mortality nowadays and, therefore, new therapeutic approaches are still needed. Rosemary (Rosmarinus officinalis L.) has been reported to possess antitumor activities both in vitro and in animal studies. Some of these activities were attributed to its major components, such as carnosic acid, carnosol, ursolic acid, and rosmarinic acid. Initially, the antitumor effects of rosemary were attributed to its antioxidant activity. However, in recent years, a lack of correlation between antioxidant and antitumor effects exerted by rosemary was reported, and different molecular mechanisms were related to its tumor inhibitory properties. Moreover, supported by the U.S. Food and Drug Administration and the European Food and Safety Authority, specific compositions of rosemary extract were demonstrated to be safe for human health and used as antioxidant additive in foods, suggesting the potential easy application of this agent as a complementary approach in cancer therapy. In this review, we aim to summarize the reported anticancer effects of rosemary, the demonstrated molecular mechanisms related to these effects and the interactions between rosemary and currently used anticancer agents. The possibility of using rosemary extract as a complementary agent in cancer therapy in comparison with its isolated components is discussed.

show abstract

“…According to WHO, herbs can be the best source to obtain a variety of drugs [16]. The herbs should be studied in a better way to understand their properties, safety, and efficiency [17][18][19].…”

Section: Herbs As Antimicrobialmentioning

confidence: 99%

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

Bhardwaj¹,

BR²,

DK³

2016

Pharm Anal Acta

View full text Add to dashboard Cite

show abstract

Assessment of selected Yemeni medicinal plants for theirin vitroantimicrobial, anticancer, and antioxidant activities

Cited by 82 publications

References 41 publications

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

Contact Info

Product

Resources

About