Assessment of Serum 25-Hydroxyvitamin D Levels in Children with Atopic Dermatitis

Taieb, Moustafa A El; Fayed, Hanan Mahmoud; Aly, Sanaa Shaker; Ibrahim, Ahmed K.

doi:10.1097/der.0000000000000010

Cited by 51 publications

(37 citation statements)

References 32 publications

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“…Also, in large population-based studies, it was observed that there is an increased likelihood of developing AD in individuals with either deficient or insufficient vitamin D levels [117,118]. Many observational studies including a meta-analysis have shown that the serum vitamin D level is lower in children and adults with AD compared to controls, and reported an association between vitamin D deficiency and risk of atopic eczema [119,120,121]. Also, the severity of AD was found to be negatively correlated with the vitamin D level, with moderate and severe AD groups having lower vitamin D levels compared to the mild AD group; this finding was supported by the use of objective tools, such as the SCORAD (Scoring Atopic Dermatitis) index, which was found to be inversely correlated with vitamin D levels in AD patients [120,121,122,123].…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

“…Many observational studies including a meta-analysis have shown that the serum vitamin D level is lower in children and adults with AD compared to controls, and reported an association between vitamin D deficiency and risk of atopic eczema [119,120,121]. Also, the severity of AD was found to be negatively correlated with the vitamin D level, with moderate and severe AD groups having lower vitamin D levels compared to the mild AD group; this finding was supported by the use of objective tools, such as the SCORAD (Scoring Atopic Dermatitis) index, which was found to be inversely correlated with vitamin D levels in AD patients [120,121,122,123]. However, there are some contradictory reports, which suggest either no role of vitamin D or a positive association of vitamin D levels with the risk of developing AD [124,125].…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

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Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

147

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

147

135

View full text Add to dashboard Cite

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“…A potential link between VD and the development of allergic disease (the so-called “vitamin D hypothesis”) first emerged when higher rates of allergic disease were observed in people residing at higher latitudes, where VDD is common [11]. Although many clinical studies have found that 25(OH)D3 levels are significantly lower in patients with AD and negatively correlated with the severity of the disease [12-14], this view has remained controversial. Recently, additional studies have indicated that VD plays an important role in the pathogenesis of AD by regulating antimicrobial peptides, modulating immunity, and affecting skin barrier functions [15, 16].…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Objective: We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. Methods: We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. Results: The VD and VA levels were significantly lower in children with AD than in normal children (p < 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.

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“…The consistency of such a finding in a large number of studies [5][6][7][17][18][19][20][21][22], confirms that the low level of calcidiol in such a disease is not a coincidence, and that calcidiol deficiency has a possible role in the pathogenesis of AD. The controversy in the serum level of calcidiol in AD patients is mainly viewed among adult AD patients, where several studies showed the non-significant alteration of calcidiol levels among patient and control groups [8,9].…”

Section: Groupmentioning

confidence: 53%

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

Youssef¹,

Dorgham²,

Hegazy³

et al. 2017

J Clin Exp Dermatol Res

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Assessment of Serum 25-Hydroxyvitamin D Levels in Children with Atopic Dermatitis

Abstract: Patients with AD have lower serum vitamin D levels than normal. Vitamin D deficiency might be related to the severity of AD.

Cited by 51 publications

References 32 publications

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

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