Assessment of Serum Calcium and Phosphorus in Pulmonary Tuberculosis Patients Before, During and After Chemotherapy

Rohini, K.; Bhat, Surekha; Srikumar, P. S.; Kumar, Ajay

doi:10.1007/s12291-013-0383-3

Cited by 19 publications

(22 citation statements)

References 10 publications

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“…In our study, the PTB subjects were just diagnosed with tuberculosis and hence immunocompromised. We also found decreased serum phosphate in these animals, the details of which we have discussed in an earlier report [3,4,[18][19][20]. The proinflammatory milieu could have reduced production of erythropoietin, suppressed response of bone marrow to erythropoietin, and altered iron metabolism, which in turn could have impaired erythropoiesis [17].…”

Section: Discussionsupporting

confidence: 65%

Assessment of Hematological Parameters in Pulmonary Tuberculosis Patients

et al. 2015

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The aim of the study was the assessment of hematological parameters in pulmonary tuberculosis patients. Forty patients diagnosed with tuberculosis were recruited from the Institute of Thoracic Medicine on the basis of history, clinical examination, chest radiography, sputum examination and related laboratory parameters and were compared with age and sex matched healthy volunteers (n = 40). Hematological parameters and CRP in tuberculosis patients were determined. The mean values for serum hemoglobin level, RBC count and platelet count in PTB was found to be less (p \ 0.001). Erythrocyte sedimentation rate (ESR), plasma C-reactive protein, WBC count in PTB subjects was increased (p \ 0.001 for ESR & CRP, p \ 0.05 for WBCs) and all were statistically significant. This study demonstrated that serum hemoglobin level, RBC count and platelet count was decreased in tuberculosis patients whereas ESR, CRP and WBC count was increased when compared with healthy controls.

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Section: Discussionsupporting

confidence: 65%

Assessment of Hematological Parameters in Pulmonary Tuberculosis Patients

et al. 2015

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“…Hypophosphatemia is a common co-morbidity in critically ill patients including sepsis ( 11 ), often leading to increased mortality, prolonged duration of MV and intensive care unit (ICU) stay ( 11 , 12 ). Some reports have suggested an association between respiratory illness and hypophosphatemia ( 13 , 14 ), the latter of which significantly contributed to failure of weaning ( 15 ) and according to Haider et al ( 16 ), was an independent risk factor for mortality in critically ill patients. It was reported that the 24-h plasma phosphate level in some ICU patients after admission, especially those with respiratory failure, decreased to the reduced renal threshold of phosphate concentration ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of hypophosphatemia on the withdrawal of mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease

Zhao

Shi

et al. 2016

Biomedical Reports

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Mechanical ventilation (MV) is a life-supporting modality frequently performed in critically ill patients to mechanically assist or replace spontaneous breathing. The aim of this study was to investigate the effect of hypophosphatemia on the withdrawal of MV in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The medical records of 67 AECOPD cases, treated with MV between 2011 and 2013, were analyzed retrospectively. The patients were assigned to the hypophosphatemic and the normophosphatemic groups according to their serum phosphate levels (with the threshold of 0.87 mmol/l). The results showed that the morbidity rate of hypophosphatemia in these AECOPD patients was 56.72%. A significantly higher percentage of failure-to-wean from MV was observed in the hypophosphatemia group vs. the normophosphatemic group (34.21 vs. 10.34%, P<0.05). Furthermore, hypophosphatemia was associated with respiratory muscular weakness, as reflected by a decrease in the tidal volume of spontaneous respiration, reduced static lung compliance and impaired pulmonary function, leading to weaning failure. The findings suggested that hypophosphatemia significantly affected the weaning from MV in AECOPD patients. Serum phosphorus levels may therefore serve as a reference index to determine the success of weaning.

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“…The mean serum Ca levels were 7.2 mg/dL and 9.4 mg/dL in the test and control groups, respectively; statistically the difference was not significant between the groups (P > 0.05). In the test group, 28% (14), 34% (17), 16% (8) and 22% (11) participants were graded as scanty, 1+. 2+ and 3+, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Several investigators studied on level of serum (Ca) among the TB patients [16][17][18][19]. But, we cannot find studies on correlation between levels of serum Ca and smear grading.…”

Section: Introductionmentioning

confidence: 99%

Correlation between serum Calcium levels and smear grading among the pulmonary tuberculosis patients

Chandra¹,

Sowjanya²

2018

Journal of Microbiology and Infectious Diseases

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Objective: To find the serum calcium (Ca) levels in the pulmonary tuberculosis (PT) patients and its correlation with smear grading. Methods: Microscopically confirmed PT patients were included in the test group and healthy individuals in the control group. Two sputum samples were collected from the participants by the same day approach. Smears were stained by Ziehl Neelsen staining technique. Simultaneously 5 ml blood was collected; serum was separated by centrifugation at 3000 rpm, 10 minutes. Serum Ca was estimated by kit method, by auto analyzer. ANOVA test was used to find the statistical significance. Results: Total 100 participants were included. The mean serum Ca levels were 7.2 mg/dL and 9.4 mg/dL in the test and control groups, respectively. Grade wise the mean serum Ca levels were 7.4 mg/dL, 7.3 mg/dL, 7.1 mg/dL and 7 mg/dL respectively for scanty, 1+. 2+ and 3+. Statistically the difference was not significant among the groups and the grades. Conclusion: As per our study hypocalcemia is observed in PT patients and the mean serum Ca levels were decreased with smear grading.

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Assessment of Serum Calcium and Phosphorus in Pulmonary Tuberculosis Patients Before, During and After Chemotherapy

Cited by 19 publications

References 10 publications

Assessment of Hematological Parameters in Pulmonary Tuberculosis Patients

Assessment of Hematological Parameters in Pulmonary Tuberculosis Patients

Effect of hypophosphatemia on the withdrawal of mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease

Correlation between serum Calcium levels and smear grading among the pulmonary tuberculosis patients

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