Assessment of Serum Ceruloplasmin Levels in Gingivitis, Chronic and Aggressive Periodontitis Patients- A Clinico-biochemical Study

Shankar, Shrinidhi Maji; Chethana, KC; G, Kavyashree; Soumya, BG; Bushan, Kala; kumar, TP Shiva

doi:10.7860/jcdr/2018/29641.11056

Cited by 2 publications

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“…In addition, it plays an essential role to decrease the levels of OS through its ability to scavenge for the free radicals (superoxide anion). According to several previous studies, Crp is an effective biomarker for several immunological conditions along with chronic gingivitis and has shown a strong association with periodontal disease activity [17,18]. The current study was proposed to detect the relationship between pregnancy status and the OS levels among gingivitis pregnant women and to elucidate the role of pregnancy status in the pathogenicity of gingivitis.…”

Section: Introductionmentioning

confidence: 98%

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2022

J. Med. Chem. Sci.

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Background: Gingivitis is an inflammation limited to marginal gingival tissues, which can be referred to as the mildest form of periodontal diseases, initial signs of inflammation which include: redness, bleeding, swelling, exudation, and to a lesser extent pain, which indicate the presence of gingivitis. Current research was proposed to detect the correlation between pregnancy status and oxidative stress (OS) levels among gingivitis pregnant women and to elucidate the role of pregnancy status in the pathogenicity of gingivitis. Methods: The current study was conducted in the Dental Center at Thi-Qar province (Iraq), and it included three study groups: 35 pregnant women with gingivitis, 35 non-pregnant women with gingivitis, and 30 non-pregnant women without gingivitis (the healthy control), with an age balance between the three study groups. Serological and salivary levels of malondialdehyde (MDA), total anti-oxidant capacity (TAC), protein carbonyl (Pc), protein, nitric oxide (NO), and ceruloplasmin (Crp) were biochemically determined. Results:The results of the tests showed that the concentrations of MDA, Pc, the total proteins (TP), NO, and Crp were significantly higher among pregnant and non-pregnant women with gingivitis compared with healthy controls in both serum and saliva, whereas the inverse findings were reported for TCA biomarker. The same results profiles were reported in comparison between pregnant women with gingivitis and non-pregnant women with gingivitis for serum biomarkers. For saliva biomarkers, the results revealed significant elevated levels of MDA, Pc, and NO among pregnant gingivitis women in comparison with non-pregnant gingivitis, whereas the other biomarkers revealed non-significant differences. Conclusions: The pregnancy status had an effect on the OS level which lead to a higher level of OS in both serum and saliva and the correlation between the pregnancy status and serum and/or saliva OS levels was positive which indicated the possible utility of its present lead to gingivitis development.

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Section: Introductionmentioning

confidence: 98%

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2022

J. Med. Chem. Sci.

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Regulation of Antioxidant Enzymes in Patients After Periodontal Treatment With Natural Agents

et al. 2022

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The aim: The study of the possibilities of oxidase-antioxidant system indicators regulation at patients with periodontitis under the influence of complex treatment. Materials and methods: 36 healthy and 125 patients with chronic and exacerbated periodontitis of primary (22 and 21), I (21) and II (20) degrees were examined.Indicators of lipid peroxidation and antioxidant protection (levels of diene conjugates and malonic dialdehyde, catalase activity and transferrin iron saturation, ceruloplasmin activity) in the blood serum were studied before, 6 and 12 months after the appointed treatment. Initial periodontal therapy and a paste developed by us (spirulina microalgae powders and silica enterosorbent taken in equal amounts and 0.05% chlorhexidine bigluconate) for applications and instillations were exogenously used in the complex treatment. Spirulina tablets were prescribed per os as well. Results: All patients exhibit elevated levels of diene conjugates and malonic dialdehyde, decreased catalase activity and transferrin iron saturation as well as an increased ceruloplasmin activity, especially pronounced at stages I and II (p1≤0.01-0.001). Treatment contributed to long-term and reliable (p2<0.05 - 0.001) regulation of the studied parameters: reduction of diene conjugates and malonic dialdehyde, ceruloplasmin activity and increased catalase activity and transferrin iron saturation. All indicators differed slightly from the norm during the year (p1>0.05), and complete normalization of most of them lasted six months. At the same time clinical stabilization of periodontitis was reached. Conclusions: Indicators of the oxidase-antioxidant system in patients with periodontitis are significantly altered and indicate their participation in the pathogenesis of the disease. Complex treatment was able to almost completely normalize them within six months, but a year later the difference between the obtained indicators with data in healthy people was insignificant (except for ceruloplasmin). Clinical stabilization was achieved in all patients.

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Assessment of Serum Ceruloplasmin Levels in Gingivitis, Chronic and Aggressive Periodontitis Patients- A Clinico-biochemical Study

Cited by 2 publications

References 0 publications

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Regulation of Antioxidant Enzymes in Patients After Periodontal Treatment With Natural Agents

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