Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome

Abstract

ObjectiveTo determine serum chemerin, vaspin and omentin-1 in overweight and normal weight patients with polycystic ovary syndrome (PCOS) and investigate the possible relationship between these adipokines and metabolic syndrome.MethodsThis cross sectional study enrolled women with PCOS and healthy women. Serum chemerin, vaspin and omentin-1 were assessed by enzyme-linked immunosorbent assay methods.ResultsForty patients with PCOS and 30 healthy controls were included in the study. In the PCOS group, 18 women were overweight (body mass index [BMI] = 25.0–29.9 kg/m2) and 22 had normal weight (BMI = 18.5–24.9 kg/m2). Chemerin, total cholesterol, dehydroepiandrosterone sulphate and free androgen index (FAI) were significantly higher; and high-density lipoprotein cholesterol and sex hormone binding globulin were significantly lower in overweight PCOS patients compared with normal weight PCOS patients. A positive correlation was found between chemerin and BMI, triglyceride, insulin, homeostatic model assessment of insulin resistance and FAI in the PCOS group. There was no difference in serum chemerin, vaspin and omentin-1 between PCOS patients and healthy controls.ConclusionCirculating chemerin was increased in overweight compared with normal weight PCOS patients. The most predictive variables for circulating chemerin in PCOS patients were BMI, FAI and age.

Pathophysiological roles of chronic low‐grade inflammation mediators in polycystic ovary syndrome

“…Studies have suggested that the PCOS status positively correlates with increased vaspin concentration (Cakal, Ustun, Engin-Ustun, Ozkaya, & Kilinç, 2011). Another study showed that there was no correlation between PCOS and vaspin levels (Guvenc, Var, Goker, & Kuscu, 2016). However, the effect of vaspin in the pathogenesis of PCOS has not been clearly specified, and further studies are needed to determine the effects of this hormone on adipose tissue and metabolism.…”

Chemerin level in a sample of Egyptian females with PCOS and its relation to insulin resistance

“…However, circulating chemerin was increased in overweight PCOS patients compared with lean PCOS patients and also they found that there was no significant difference between normal and overweight controls in serum chemerin. These findings suggest that BMI alone is not a predictive factor for circulating chemerin [11]. But this study did not include obese patients or patients with insulin resistance, which may explain the lack of any difference between groups.…”

Omentin rs2274907 gene polymorphism and the risk of metabolic syndrome: a preliminary report

“…However, after using multiple regression analysis they found an association between fasting glucose and circulating omentin-1 levels. Guvenc et al did not find a correlation between serum omentin levels and components of MetS such as fasting glucose, HDL-cholesterol, and triglycerides in women with polycystic ovary syndrome [28]. Elsaid et al showed that omentin-1 is inversely related to waist circumference and systolic blood pressure [29].…”