Assessment of Serum Chromium and Zinc Levels in Patients with Chronic Renal Failure

Abstract

Background: Chromium (Cr) and Zinc (zn) are very important in human nutrition. Many researchers reported that serum chromium and serum zinc are impaired in patients with chronic renal failure,(CRF).
 Objectives: This study aimed to assess chromium and Zinc in chronic renal failure patients.
 Materials and Methods: This study was conducted at Khartoum state during November 2017 to May 2018.The study enrolled 35 patients with CRF and 40 healthy controls. Serum Chromium and Zinc levels were estimated using Atomic absorption spectrophotometry, (AAS), technique.
 Results: the current study demonstrated a highly significant a lower level of Cr in patients in contrast to healthy controls, (0.032 versus 0.147 mg/dl; respectively, P<0.001), and also of Zn level in patients as compared to healthy controls (0.165 versus 0.564 mg/dl; respectively, P<0.001). In contrary, the level of both Cr and Zn were significantly higher after dialysis as compared to their levels, before dialysis (0.137 versus 0.032 mg/dl; respectively, P<0.001) and (0.253 versus 0.165 mg/dl; respectively, P<0.001) for Cr and Zn, respectively.
 Conclusion: The present study revealed that, Zn and Cr levels decreased in CRF patients and increased after dialysis.

The effect of oral zinc on hemoglobin and dose of erythropoietin in hemodialysis patients

“…[ 20 21 ] In this regard, Rahamtalla said that in patients with renal failure, zinc level significantly decreased compared to the control group. [ 22 ] In renal failure, patients have disturbances in acid-base balance leading to acidic blood pH, therefore low zinc levels in these patients are believed to be due to the shift of zinc into red blood cells under acidic conditions. [ 23 ]…”