Assessment of Serum Cx3Cl1/Fractalkine Level in Han Chinese Girls with Anorexia Nervosa and its Correlation with Nutritional Status: A Preliminary Cross-Sectional Study

Zhang, Shengkang; Tang, Hanfeng; Gong, Cai; Liu, Jiang; Chen, Jindong

doi:10.1136/jim-2016-000209

Cited by 6 publications

(3 citation statements)

References 38 publications

(53 reference statements)

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“…Chemokines are a subcategory of smaller cytokines known to induce chemotaxis, with some also having a homeostatic function in relation to haematopoiesis, immune surveillance, and adaptive immune system responses [ 21 , 22 ]. The chemokines RANTES, monocyte chemoattractant protein (MCP)-1, and fractalkine have been measured in two studies in people with AN [ 23 , 24 ]. Similarly, adhesion molecules, which mediate the binding of cells in the immune system [ 25 ], have been measured in one study in a sample of people with AN [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Markers in Anorexia Nervosa: An Exploratory Study

et al. 2018

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Inflammation has been suggested to play a pathophysiological role in anorexia nervosa (AN). In this exploratory cross-sectional study, we measured serum concentrations of 40 inflammatory markers (including cytokines, chemokines, and adhesion molecules) and brain-derived neurotrophic factor (BDNF) in people with AN (n = 27) and healthy controls (HCs) (n = 13). Many of these inflammatory markers had not been previously quantified in people with AN. Eating disorder (ED) and general psychopathology symptoms were assessed. Body mass index (BMI) and body composition data were obtained. Interleukin (IL)-6, IL-15, and vascular cell adhesion molecule (VCAM)-1 concentrations were significantly elevated and concentrations of BDNF, tumor necrosis factor (TNF)-β, and vascular endothelial growth factor (VEGF)-A were significantly lower in AN participants compared to HCs. Age, BMI, and percentage body fat mass were identified as potential confounding variables for several of these inflammatory markers. Of particular interest is that most of the quantified markers were unchanged in people with AN, despite them being severely underweight with evident body fat loss, and having clinically significant ED symptoms and severe depression and anxiety symptoms. Future research should examine the replicability of our findings and consider the effect of additional potential confounding variables, such as smoking and physical activity, on the relationship between AN and inflammation.

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Section: Introductionmentioning

confidence: 99%

Inflammatory Markers in Anorexia Nervosa: An Exploratory Study

et al. 2018

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“…IL-10 levels were also associated with post-dinner eating and "not having sweet eating" (21). Serum fractalkine levels were higher in adolescent girls with obesity but lower in AN compared to healthy controls (30). Lucas et al (25) found that plasma levels of a-MSH/IgG immune complex in individuals with obesity were lower than healthy controls (25).…”

Section: Descriptive Synthesis Of Main Findingsmentioning

confidence: 99%

An evidence review of the association of immune and inflammatory markers with obesity-related eating behaviors

Meng

Kautz

2022

Front. Immunol.

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BackgroundEating behaviors contribute to disproportionate energy intake and are linked to the development of obesity. Animal studies support the role of inflammatory cytokines and chemokines in the regulation of obesity-related eating behaviors and offer a potential target to combat obesity through the modulation of inflammation. However, more complex eating behaviors are present in humans, and their relationships with immune/inflammation markers are unclear. The present study reviewed current literature to synthesize the evidence on the association of immune/inflammation markers with obesity-related eating behaviors in humans.MethodsA systematic search of three electronic databases yielded 811 articles, of which 11 met the inclusion criteria.ResultsThe majority of the included studies (91%) were either case-control or cross-sectional studies. A variety of immune/inflammation markers and obesity-related eating behaviors have been assessed in the chosen studies. Three out of four studies identified a positive relationship between C-reactive protein (CRP)/high-sensitivity CRP and loss of control eating. Other inflammatory markers that potentially have a positive relationship with obesity-related eating behaviors include fractalkine and fibrinogen. Additionally, immune molecules, including interferon gamma (INF-γ), interleukin (IL)-7, IL-10, and α-melanocyte-stimulating hormone-reactive immunoglobulin G (α-MSH/IgG) immune complex, may have negative associations with obesity-related eating behaviors. However, most findings were identified by single studies.ConclusionLimited studies have been conducted in humans. Current evidence indicates a potential bi-directional relationship between inflammatory/immune markers and obesity-related eating behaviors. Additional studies with sophisticated research design and comprehensive theoretical models are warranted to further delineate the relationship between immune/inflammation markers and obesity-related eating behaviors.

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“…A bidirectional relationship between different chemokine-chemokine receptor axes and the secretion of leptin, a hormone that regulates appetite through a posttranscriptional mechanism, was found (37,38). Recent studies provide insights into blood chemokine levels in AN with controversial results (24,(39)(40)(41)(42). Dalton and colleagues found unchanged serum concentrations of several chemokines among those CCL2 (MCP-1), CCL3 (MIP-1α), CCL4 (MIP-1β), CCL11 (Eotaxin), CCL13 (MCP-4), CCL17 (TARC), and CCL26 (Eotaxin-3) in 23 subjects with AN compared to 13 HC (31).…”

Section: Introductionmentioning

confidence: 99%

Expression of CXCR4 on CD4+ T cells predicts body composition parameters in female adolescents with anorexia nervosa

et al. 2022

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Anorexia nervosa (AN) is a severe eating disorder characterized by excessive weight loss and lack of recognition of the seriousness of the current low body weight. Individuals with AN frequently exhibit an enhanced inflammatory state and altered blood levels of cytokines and chemokines. However, the expression of chemokine receptors in AN and the association with body composition parameters and treatment effects are still unknown. In this study, we examined the expression of CCR4, CCR6, CXCR3, and CXCR4 on peripheral blood T cells in female adolescents with AN before (T0, n = 24) and after 6 weeks of multimodal therapy (T1, n = 20). We also investigated their value to predict body mass index (BMI) and fat mass index (FMI) at baseline. Using multi-parameter flow cytometry, we found increased expression of CCR4, CXCR3, and CXCR4, but not CCR6, on CD4+ T cells in AN at T0 when compared to healthy controls (HC, n = 20). At T1, CXCR3 and CXCR4 expression decreased in AN. We found a close link between CCR4, CCR6 and CXCR4 expression and the adolescent mental health status in the study cohort as determined by the Strengths and Difficulties Questionnaire (SDQ). Specifically, CXCR4 expression correlated positively with emotional symptoms and peer relationship problems, as well as with the total sum score of the SDQ. In addition, CXCR4 expression on CD4+ T cells was a significant predictor of BMI and FMI in female adolescents. Our findings that CXCR4 expression on T cells is altered in adolescents with AN and predicts body composition parameters in adolescents suggest an impact of this chemokine receptor in the pathogenesis of AN.

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Assessment of Serum Cx3Cl1/Fractalkine Level in Han Chinese Girls with Anorexia Nervosa and its Correlation with Nutritional Status: A Preliminary Cross-Sectional Study

Cited by 6 publications

References 38 publications

Inflammatory Markers in Anorexia Nervosa: An Exploratory Study

Inflammatory Markers in Anorexia Nervosa: An Exploratory Study

An evidence review of the association of immune and inflammatory markers with obesity-related eating behaviors

Expression of CXCR4 on CD4+ T cells predicts body composition parameters in female adolescents with anorexia nervosa

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