Assessment of serum interleukin 19 level in patients with warts

Abstract

<abstract> <p>Background: Warts are viral cutaneous infections caused by human papilloma virus (HPV), presented by verrucous growth over the skin surface. The cell mediated immune response is considered to play a crucial role in HPV clearance. The viral load and number of lesions increase when there is an imbalance between the T-helper 1 and T-helper 2 immune responses. Interleukin (IL)-19 is a cytokine that belongs to interleukin 10 cytokines family and constitutes a sub-family with IL-20, IL-22 and IL-24. IL-19 is mainly produced by activated monocytes and to a lesser extent by B-cells, keratinocytes and fetal membranes. IL-19 was found to shift T-cell maturation away from the pro-inflammatory T-helper 1 cells toward the anti-inflammatory T-helper 2 cells. It induces IL-4 and IL-13 production in T cells and apoptosis in monocytes. Aim: This study aimed to measure serum level of IL-19 in patients with warts compared to healthy controls and to find out the correlation between this level and number, size and clinical types of warts. Methods: The study included 50 patients with warts and 50 control subjects. Serum concentration of IL-19 was measured by enzyme-linked immune sorbent assay. Results: Interleukin-19 serum level was significantly lower in patients with warts than in controls (P < 0.003). Moreover, there was a significant positive correlation between IL-19 serum level and the number of warts (P = 0.027). Conclusion: Serum level of IL-19 was significantly lower in patients with warts, and this low level might be crucial for an effective cell mediated immunological response to HPV.</p> </abstract>

Evaluation of the Tissue Level of CXCL10 in Patients with Verruca Vulgaris

“…Therefore, our objective was to assess the tissue expression of CXCL10 in cutaneous verruca lesions.The study involved 50 patients with verruca vulgaris, with 30 healthy skin biopsies from the same patients serving as a control group. Notably, the most commonly affected site was the limbs, mirroring the vulnerability of these areas to HPV infection due to their frequent exposure[13] . Tissue CXCL-10 levels were significantly elevated in verruca lesions than in healthy skin biopsies, possibly indicating a dual role for CXCL-10 in DNA viral infections, based on viral type and host immune status.…”