Assessment of serum interleukin-6 with a rapid test. The diagnosis of neonatal sepsis can be established or ruled out

Görbe, Éva; Jeager, Judit; Nagy, Bálint; Harmath, Ágnes; Hauzman, Erik; Hruby, Ervin; Kőhalmi, Barbara; Perlaki, Mónika; Sassi, Lilla; Rab, Attila

doi:10.1556/oh.2007.27991

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Neonatal sepsis is a frequent complication of very low birth weight (VLBW) infants and it is an important cause of neonatal morbidity and mortality [1, 2]. VLBW infants develop 2.7 times more sepsis than other infants since their immune system and skin barrier are immature and they are exposed to many invasive diagnostic and therapeutic procedures [3].…”

Section: Introductionmentioning

confidence: 99%

Sepsis-Related Mortality of Very Low Birth Weight Brazilian Infants: The Role ofPseudomonas aeruginosa

Pereira

Cardoso²,

Figuexeds

et al. 2009

International Journal of Pediatrics

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The aim of this study is to identify risk factors for sepsis-related mortality in low birth weight (<1500 g) infants. We performed retrospective cohort study to investigate risk factors for sepsis-related mortality in all neonates birth weight <1500 g admitted to Level III neonatal intensive care unit, Brazil, April 2001/September 2004. Of the 203 cases, 71 (35%) had sepsis. Of those, gram-positive was identified in 52/87 blood cultures (59.8%), the most common Coagulase-negative Staphylococcus (31/87; 35.5%). Gram-negative was present in 29 of the 87 positive blood cultures (33.3%), with Pseudomonas aeruginosa (8/87; 9.1%), the most frequent agent. Overall 21 of 71 infants with sepsis (29.6%) died. Risk factors for sepsis-related mortality were gestational age ≤28 weeks, birth weight ≤1000 g (9.6 times more often than birth weight >1000 g), five-minute Apgar ≤7, gram-negative sepsis, mechanical ventilation (6.7 times higher than no use), and intravascular catheter. Sepsis-related mortality was due, mainly, to Pseudomonas aeruginosa; birth weight ≤1000 g and mechanical ventilation were strong sepsis-related mortality predictors.

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Section: Introductionmentioning

confidence: 99%

Sepsis-Related Mortality of Very Low Birth Weight Brazilian Infants: The Role ofPseudomonas aeruginosa

Pereira

Cardoso²,

Figuexeds

et al. 2009

International Journal of Pediatrics

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C-reactive protein for diagnosing late-onset infection in newborn infants

Brown

Meader

Cleminson

et al. 2019

Cochrane Database of Systematic Reviews

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Background Late-onset infection is the most common serious complication associated with hospital care for newborn infants. Because confirming the diagnosis by microbiological culture typically takes 24 to 48 hours, the serum level of the inflammatory marker C-reactive protein (CRP) measured as part of the initial investigation is used as an adjunctive rapid test to guide management in infants with suspected late-onset infection. Objectives To determine the diagnostic accuracy of serum CRP measurement in detecting late-onset infection in newborn infants. Search methods We searched electronic databases (MEDLINE, Embase, and Science Citation Index to September 2017), conference proceedings, previous reviews, and the reference lists of retrieved articles. Selection criteria We included cohort and cross-sectional studies evaluating the diagnostic accuracy of serum CRP levels for the detection of late-onset infection (occurring more than 72 hours after birth) in newborn infants. Data collection and analysis Two review authors independently assessed eligibility for inclusion, evaluated the methodological quality of included studies, and extracted data to estimate diagnostic accuracy using hierarchical summary receiver operating characteristic (SROC) models. We assessed heterogeneity by examining variability of study estimates and overlap of the 95% confidence interval (CI) in forest plots of sensitivity and specificity. Main results The search identified 20 studies (1615 infants). Most were small, single-centre, prospective cohort studies conducted in neonatal units in high-or middle-income countries since the late 1990s. Risk of bias in the included studies was generally low with independent assessment of index and reference tests. Most studies used a prespecified serum CRP threshold level as the definition of a 'positive' index test (typical cutoff level between 5 mg/L and 10 mg/L) and the culture of a pathogenic microorganism from blood as the reference standard.

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Utilidad de un test rápido de interleuquina-6 sérico combinado con proteína C reactiva para predecir la sepsis en recién nacidos con sospecha de infección

Mosquera

Monzo

Salguero

et al. 2009

Anales de Pediatría

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Assessment of serum interleukin-6 with a rapid test. The diagnosis of neonatal sepsis can be established or ruled out

Cited by 4 publications

References 19 publications

Sepsis-Related Mortality of Very Low Birth Weight Brazilian Infants: The Role ofPseudomonas aeruginosa

Sepsis-Related Mortality of Very Low Birth Weight Brazilian Infants: The Role ofPseudomonas aeruginosa

C-reactive protein for diagnosing late-onset infection in newborn infants

Utilidad de un test rápido de interleuquina-6 sérico combinado con proteína C reactiva para predecir la sepsis en recién nacidos con sospecha de infección

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