Assessment of serum iron stores in regular plateletpheresis donors

Sab, Pinjari Chinigi; Kaur, Gagandeep; Kaur, Paramjit; Tahlan, Anita; Bedi, Ravneet Kaur; Mittal, Kshitija; Sood, Tanvi

doi:10.1016/j.transci.2021.103291

Cited by 12 publications

(10 citation statements)

References 15 publications

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“…However, a previous study had reported no increase in likelihood of ID in donors who only donated apheresis components, regardless of frequency [20]. In our study, the correlation between ferritin and platelet count was insignificant, in contrast to another study that reported a significant negative correlation [16]. Other studies have found that blood donors with ID have a lower prevalence of elevated platelet counts compared to individuals with IDA, suggesting an exaggerated response in anaemic individuals that was probably not replicated to the same extent in individuals with ID [21][22][23].…”

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

“…We observed a significant negative correlation of ferritin with both recent and lifetime donations, consistent with other studies reporting increased ID with higher frequency of donation [16, 17]. However, a previous study had reported no increase in likelihood of ID in donors who only donated apheresis components, regardless of frequency [20].…”

Section: Discussionsupporting

confidence: 90%

“…Plateletpheresis donors are eligible to donate up to 24 times/year in several countries like United States and India, since it is thought that the red cell losses were significantly lower than in whole blood donation [3]. Platelet donors could experience an annual whole blood loss of ≈1900–2400 mL if they are to donate at the maximum allowable frequency, which would be much higher than for a blood donor donating at the maximum frequency allowed for whole blood donation [16].…”

Section: Discussionmentioning

confidence: 99%

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‘Ironing out the risk’: Assessing the effect of plateletpheresis donation frequency on iron stores in South‐Asian male donors

Madkaiker,

Hiregoudar,

Chavan

et al. 2023

Vox Sanguinis

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Background and ObjectivesRepeated blood donation is a well‐known cause of iron deficiency among donors. However, present scientific literature lacks comprehensive evidence regarding the impact of regular plateletpheresis procedures on body iron reserves. In this study, we aimed to detect and correlate iron deficiency (using iron indices) with the frequency of platelet donations. Additionally, we also analysed the correlation between other iron and haematological indices with serum ferritin to determine cost‐effective parameters that may serve as an initial screening approach to determine which donors should be subjected to serum ferritin testing.Materials and MethodsA total of 180 male participants from our platelet donor registry were enrolled in this observational cross‐sectional study. Enrolment questionnaires were administered to eligible donors, and biological samples were collected during plateletpheresis donation. Biological tests such as complete blood count, reticulocyte indices, iron indices, vitamin B12 and folate were performed.ResultsDonors with ≥12 donations per year showed the highest prevalence of low ferritin (serum ferritin: 15–30 ng/mL) and absent iron stores (serum ferritin <15 ng/mL) (41.3% and 26.7%, respectively). Ferritin showed a significant negative correlation with recent (r = −0.346) and lifetime donations (r = −0.196). The efficacy of other indices for identifying iron depletion was much better using a serum ferritin value <15 ng/mL.ConclusionRegular plateletpheresis donations can lead to varying severities of non‐anaemic iron deficiency. Blood centres must regularly monitor frequent plateletpheresis donors (especially donors with more than 11 donations in a calendar year) and ideally maintain their serum ferritin above 30 ng/mL.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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‘Ironing out the risk’: Assessing the effect of plateletpheresis donation frequency on iron stores in South‐Asian male donors

Madkaiker,

Hiregoudar,

Chavan

et al. 2023

Vox Sanguinis

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“… 29 Similarly, a study from India showed that regular plateletpheresis donation may lead to depletion of iron stores and subclinical iron deficiency. 30 …”

Section: Introductionmentioning

confidence: 99%

Iron Deficiency and Blood Donation: Links, Risks and Management

Mantadakis¹,

Panagopoulou²,

Kontekaki³

et al. 2022

JBM

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The purpose of this review is to raise awareness about the frequently underappreciated association of blood donation with iron deficiency, and to describe methods for its prevention and management. Blood donors cannot expect any health benefits from the donation but have justified expectations of no harm. Iron deficiency without anemia (IDWA) and iron deficiency anemia (IDA) are common consequences of regular blood donation, and this activity is the most important factor affecting iron status in regular blood donors. Awareness of blood donation as a primary cause of sideropenia is surprisingly low among physicians. Blood donation screening identifies potential donors with IDA but is frequently inadequate to detect IDWA. For the assessment of body iron stores, plasma or serum ferritin, transferrin saturation (TSAT) and soluble transferrin receptors (sTfR) concentrations are the most widely used biochemical markers, although the percentage of hypochromic mature erythrocytes and the hemoglobin content of reticulocytes are also useful. IDWA can be prevented by limiting the total volume of blood collected, by iron deficiency screening and deferral of sideropenic donors, by prolonging the interdonation intervals, and by iron supplementation between donations. IDWA tends to be more prevalent in younger people, females, and high-intensity donors. A potentially effective strategy to address sideropenia in blood donors is serum ferritin testing, but this may lead to a higher rate of deferral. Most regular blood donors cannot replenish their iron deficit by an iron-rich diet alone and will benefit from low-dose oral iron administration with various commercially available products post-donation, a well-tolerated strategy. However, valid concerns exist regarding the possibility of worsening the iron overload in donors with undiagnosed hemochromatosis or masking the symptoms of a clinically important gastrointestinal hemorrhage or other underlying medical condition. Finally, educational efforts should be intensified to improve the awareness of blood donation as a primary cause of iron deficiency among physicians of all specialties.

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