Assessment of serum level of vitamin D in infants and children with Down syndrome

ElAwady, Heba; El-Hawary, Manal; Elshafie, Shahira; Ragab, Tamer; Nabile, Raooth

doi:10.4103/mxe.mxe_10_18

Cited by 3 publications

(6 citation statements)

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“…In this cross-sectional study, we detected notably lower VD levels in children with DS, with a median value of 31.89 (3.77-102.68) ng/mL compared to controls (56.19 [19.05-173.19] ng/mL). El-Hawary et al also reported a mean VD level of 30.65 ± 20.64 ng/mL in children with DS [11]. This nding was consistent with studies that found lower levels of VD in DS patients than controls.…”

Section: Discussionsupporting

confidence: 75%

“…This nding was consistent with studies that found lower levels of VD in DS patients than controls. [9][10][11] Our study showed that 14 out of 80 participants (17.5%) had VDD and 23 of 80 children with DS (28.7%) had VD insu ciency (VDI). In contrast, in the non-DS group, only 2/42 (4.5%) children had VDD and 6/42 had VDI.…”

Section: Discussionmentioning

confidence: 73%

“…VD su ciency in our study was much higher than in previously reported studies, both in the DS population. 10,11 and in healthy Indonesian children. 23,24 This difference may be due to the different cut-off values used to determine VDD.…”

Section: Discussionmentioning

confidence: 97%

“…7 thus, their overexpression due to trisomy 21 leads to the consistent activation of the IFN transcriptional response through the overexpression of IFN-stimulated genes (ISGs), resulting in IFN hypersensitivity (interferonopathy) that is associated with an increased risk of various autoimmune diseases in this population. 11 It is estimated that individuals with DS are four to six times more likely to develop autoimmune diseases such as celiac disease, T1DM, and autoimmune thyroiditis (AITD). 8 as well as susceptibility to leukemia 12 and life-threatening conditions of immune dysregulation primarily driven by the cytokine IFN-γ, such as hemophagocytic lymphohistiocytosis (HLH) 13 .…”

Section: Introductionmentioning

confidence: 99%

“…8 as well as susceptibility to leukemia 12 and life-threatening conditions of immune dysregulation primarily driven by the cytokine IFN-γ, such as hemophagocytic lymphohistiocytosis (HLH) 13 . Several studies have found lower VD levels in children with DS than in children without DS [9][10][11] ; this has recently been tied to an increased risk of autoimmunity 14 . However, DS patients spend more time indoors and are physically less active 15 , whereas if DS patients have regular sun exposure, they do not require VD supplementation 16 .…”

Section: Introductionmentioning

confidence: 99%

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The Role of Vitamin D On Interferon- Levels in Indonesian Children with Down Syndrome And Its Contributing Factors: A Cross-sectional Study

Hisbiyah

Endaryanto

Setyoboedi

et al. 2023

Preprint

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Background Vitamin D (VD) plays a role in reducing the risk of diseases related to the immune system, including autoimmune diseases, by inhibiting proinflammatory cytokines such as IFN-γ. Children with Down syndrome (DS) are known to have interferonopathy due to trisomy 21 and have lower VD levels. This study aimed to evaluate the VD profile in Indonesian children with DS and its correlation with IFN-γ.Methods This study was conducted from March 2020 to June 2021 at Dr. Soetomo General Hospital, Surabaya. Data on sociodemographic status, milk, fish, and meat consumption, and sun exposure were obtained using a self-report questionnaire. VD and IFN-γ levels were measured using an ELISA kit. The chi-square test, t-test, Mann–Whitney test, and linear and logistic regression analysis were performed, with a significance threshold of p < 0.05.Results Of the 122 participants, 80 children had DS and 42 did not. The median VD levels in the DS and non-DS groups were 31.98 ng/mL and 56.19 ng/mL, respectively. The IFN-γ level was higher in the DS group, but this difference was not statistically significant (122.978 ± 123.420 vs. 100.715 ± 97.137 ng/mL, p = 0.548). Children with DS had lower daily milk consumption (300 cc/day vs. 380 cc/day; p = 0.027), sun exposure (17.5 vs. 150 hours/week; p = 0.000), and weekly meat and fish consumption (1 vs. 4 slices/week; p = 0.000). Daily milk consumption was a significant contributing factor for VD adequacy in the DS group (p = 0.000 [OR = 1.008]). VD levels had a significant role in decreasing IFN-γ levels in the DS group (p = 0.039; R2 = 5.8%).Conclusions VD levels in children with DS are lower than in children without DS. Adequate milk consumption can reduce the risk of autoimmunity through the role of VD in reducing IFN-γ levels in children with DS.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Vitamin D On Interferon- Levels in Indonesian Children with Down Syndrome And Its Contributing Factors: A Cross-sectional Study

Hisbiyah

Endaryanto

Setyoboedi

et al. 2023

Preprint

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Evaluation of nutritional status of young adolescents diagnosed with Down syndrome: a descriptive study

Kahraman,

Karsli,

Ihlamur

2024

Nutrire

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Untitled

2024

J. Med. Chem. Sci.

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Background: Down's syndrome (DS) is a prevalent autosomal disorder that is widely observed on a global scale. Children diagnosed with DS have several environmental and hormonal factors that impact their development. Vitamin D (VD) plays a crucial role in conferring a protective effect to the human body. However, there is a scarcity of study on VD and the factors that influence its level in Indonesian Down's syndrome children. The primary purpose of this research was to examine the levels of VD and the factors that influence them among children in Indonesia diagnosed with DS. Methods: Using a cross-sectional method of Indonesian DS and control children (aged 1 month to18 years), the subjects' VD concentration was evaluated using Elisa and classified into sufficient and non-sufficient groups based on the results. The determinant factors consisted of the subjects' characteristics: demographic characteristics, milk intake, sun exposure, and meat consumption. Kruskal-Wallis, Chi-Squared, Spearman's correlation, and regression tests were used for statistical analysis; outcome was considered significant if p-values <0.05. Results: Thirty children with DS and 30 healthy controls were recruited as participants. The mean VD levels in the DS and control groups were 38.74 ng/mL and 70.109 ng/mL, respectively. The rate of VD insufficiency was 33.3% and 26.7% in the DS children and healthy controls, respectively. A significant difference in age, milk intake, body mass index, sun exposure, and meat consumption was observed (p-values lower than 0.05). Conclusions:The VD concentration in the DS was below the control group.The key determining factors were the level of milk consumption and exposure to sunlight.

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Assessment of serum level of vitamin D in infants and children with Down syndrome

Cited by 3 publications

References 1 publication

The Role of Vitamin D On Interferon- Levels in Indonesian Children with Down Syndrome And Its Contributing Factors: A Cross-sectional Study

The Role of Vitamin D On Interferon- Levels in Indonesian Children with Down Syndrome And Its Contributing Factors: A Cross-sectional Study

Evaluation of nutritional status of young adolescents diagnosed with Down syndrome: a descriptive study

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