Assessment of serum levels of osteopontin, selenium and prolactin in patients with psoriasis compared with healthy controls, and their association with psoriasis severity

Toossi, Parviz; Amini, Shima; Amini, Massoud; kia, Masoud Partovi; Enamzade, R.; Kazeminejad, Armaghan; Radvar, Siamak Esmaeily; Younespour, Shima

doi:10.1111/ced.12657

Cited by 18 publications

(25 citation statements)

References 21 publications

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“…What is more, OPN concentration did not significantly differ between the group of patients with mild psoriasis and the group with moderate or severe disease severity (p = 0.713). Similar results were obtained by other authors who did not find a relationship between plasma OPN concentration and PASI value 16,21,24,[28][29][30] either. However, different data was presented by Kadry et al, who showed a positive correlation between plasma OPN concentration and the clinical severity of psoriasis.…”

Section: Discussionsupporting

confidence: 91%

“…20 In our study, a significantly higher concentration of OPN in the group of psoriatic patients in comparison to the healthy volunteers (p < 0.001) was observed, which is in agreement with the results reported by other authors. [21][22][23][24] In 2016, Abdel-Mawla et al observed significantly higher OPN expression in the psoriatic plaques in comparison to the healthy skin as well as to the unchanged skin in psoriatic patients. 25 Moreover, the expression of OPN in the unchanged skin of psoriatic patients was significantly higher than in the healthy skin of the healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

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Serum concentration of osteopontin and interleukin 17 in psoriatic patients

et al. 2020

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Background. Psoriasis is a chronic, autoinflammatory disease characterized by activation and differentiation of naive T lymphocytes towards T helper CD4 + (including Th1 and Th17) and T cytotoxic CD8 + . Osteopontin (OPN), which plays an important role in both physiological processes and inflammatory, neoplastic and autoimmune diseases, is also considered in the context of psoriasis pathogenesis. Current data indicates that OPN is a multifunctional protein involved in the modulation of Th1 and Th17 cellular responses, in stimulating keratinocyte proliferation, and in the regulation of cellular apoptosis.Objectives. The assessment of OPN and interleukin 17 (IL-17) concentrations in the peripheral blood of psoriatic patients in comparison to healthy volunteers as well as the correlations of OPN and IL-17 with the severity of psoriasis.Material and methods. The study included 107 male psoriatic patients and 41 age-matched healthy men. The serum concentrations of IL-17 and OPN were examined using the enzyme-linked immunosorbent assay (ELISA) method. The skin change severity of psoriasis was assessed using the Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), Physician Global Assessment (PGA), and Dermatology Life Quality Index (DLQI).Results. Psoriatic patients had significantly higher concentrations of OPN (31.65 ng/mL on average) than the healthy volunteers (11.42 ng/mL on average) (p < 0.001). Interleukin 17 was also higher in psoriatic patients (0.53 pg/mL on average) compared to healthy volunteers (0.09 pg/mL on average) (p < 0.001). There was no significant correlation between OPN and IL-17 concentrations in psoriatic patients and in healthy volunteers. Psoriasis severity correlated positively to IL-17 serum concentration, but not to OPN. Conclusions.Although the study did not show a relationship between OPN and IL-17 concentrations in psoriatic patients, it should be emphasized that serum concentrations were significantly higher in the patients with psoriasis compared to healthy volunteers.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Serum concentration of osteopontin and interleukin 17 in psoriatic patients

et al. 2020

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“…OPN is highly expressed in chronic inflammatory and autoimmune diseases. Increased OPN serum levels have been reported in several autoimmune diseases such as rheumatoid arthritis (RA), allergic diseases, Crohn's disease, psoriasis (Robati et al, ; Toossi, Sadat Amini, Sadat Amini, et al, ), and multiple sclerosis (MS) (Lund, Giachelli, & Scatena, ). Recent advances suggest the possibility that OPN could be a promising therapeutic target for autoimmune diseases (Morimoto, Kon, Matsui, & Uede, ).…”

Section: Introductionmentioning

confidence: 99%

The elevated level of osteopontin in patients with pemphigus vulgaris: A cytokine‐like protein with a therapeutic potential

Ketabi

Nasiri

Kheirodin

et al. 2019

Dermatologic Therapy

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Background Pemphigus vulgaris (PV) is a life‐threatening autoimmune disease with no certain treatment. Anticytokine therapy is being increasingly discussed in multiple autoimmune diseases. Osteopontin (OPN) is a glycoprotein produced by a variety of immune cells. Increased OPN serum levels have been reported in several autoimmune diseases, with targeting OPN considered as a promising therapy in these diseases. However, the role of OPN in PV has not been well studied so far. Objective To investigate whether OPN level is elevated in PV patients in the active stage of the disease and to examine its possible relationship with disease severity and anti‐desmoglein (anti‐Dsg) antibodies levels. Materials and Methods This study included 53 consecutive subjects affected by PV and 38 age‐ and sex‐matched healthy controls. Clinical characteristics and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) were assessed. Serum OPN levels (pg/mL) and anti‐Dsg antibodies were also measured. Results The serum OPN level of the patient group proved to be statistically higher than that of the control group (11.08 ± 5.24 vs 8.47 ± 5.68; p = .02). No significant relationship were detected between the serum OPN level and anti‐Dsg1 or anti‐Dsg3 antibodies (r = 0.1, p = .2 and r = 0.1, p = .4), respectively. In addition, no correlation was found between serum OPN levels and severity of PV as measured by ABSIS (r = 0.08 and p = .5). Conclusion The growth observed in OPN levels in pemphigus patients suggests the role of OPN in pemphigus pathogenesis, but there is a need for more extensive studies to show how OPN can be associated with the PV pathogenesis and whether OPN could be used as an important therapeutic target in pemphigus disease.

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“…However, studies that have compared circulating PRL levels in patients with psoriasis and healthy controls (HCs) and determined the relation between PRL levels and psoriasis severity have shown mixed results . Such disparities may be a result of small sample sizes, low statistical power and/or clinical heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Association between circulating prolactin levels and psoriasis and its correlation with disease severity: a meta-analysis

Lee

Song

2017

Clin Exp Dermatol

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SummaryBackground. Studies that have compared circulating prolactin (PRL) levels in patients with psoriasis and healthy controls (HCs) and determined the relation between PRL levels and psoriasis severity have shown mixed results. Aim. To evaluate the association between circulating PRL levels and psoriasis, and between serum/plasma PRL levels and psoriasis severity. Methods. We performed a meta-analysis comparing serum/plasma PRL levels in patients with psoriasis with those of HCs, and examined the correlation coefficients for circulating PRL levels and psoriasis severity based on Psoriasis Area and Severity Index (PASI). Results. In total, 12 studies assessing 446 patients with psoriasis and 401 HCs were included. PRL levels were significantly higher in the psoriasis group than in the HC group [standardized mean difference (SMD) 0.54; 95% CI = 0.18-090; P < 0.01). Stratification by age and sex revealed a significantly higher PRL level in the psoriasis group (SMD = 0.53; 95% CI = 0.15-0.91; P < 0.01). Subgroup analysis by sample size showed a significantly higher PRL level with larger sample sizes (n ≥ 80) (SMD = 0.51, 95% CI = 0.07-0.95, P = 0.02), but not with smaller sample sizes (n < 80) in the psoriasis group. Stratification by sample type revealed a significantly higher level of PRL in the sera, but not plasma of the psoriasis group. Metaanalysis of the correlation coefficients showed a positive, although not statistically significant, correlation between circulating PRL levels and PASI (correlation coefficient = 0.48, 95% CI = À0.05 to 0.80, P = 0.08). Conclusion. Circulating PRL levels are higher in patients with psoriasis, and PRL levels may correlate with psoriasis severity.

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Assessment of serum levels of osteopontin, selenium and prolactin in patients with psoriasis compared with healthy controls, and their association with psoriasis severity

Abstract: High plasma OPN is a predictor for occurrence of psoriasis. Our study showed that serum selenium and PRL were not decreased in patients with psoriasis, but there was a negative statistically significant correlation between OPN and selenium in all participants.

Cited by 18 publications

References 21 publications

Serum concentration of osteopontin and interleukin 17 in psoriatic patients

Serum concentration of osteopontin and interleukin 17 in psoriatic patients

The elevated level of osteopontin in patients with pemphigus vulgaris: A cytokine‐like protein with a therapeutic potential

Association between circulating prolactin levels and psoriasis and its correlation with disease severity: a meta-analysis

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