Assessment of serum levels of copeptin and corticotropin-releasing factor in children with monosymptomatic and non-monosymptomatic nocturnal enuresis

Girişgen, İlknur; Avcı, Esin; Yüksel, Selçuk

doi:10.1016/j.jpurol.2019.05.017

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…OAB, a common condition characterized by increased frequency of smaller volume voids, has a significant impact on quality of life and effective therapies are few (Tang et al, 2014). Interestingly, two recent clinical studies found significantly lower serum CRH level in children with nocturnal enuresis (i.e., bedwetting) compared with control children (Motawie et al, 2017;Girisgen et al, 2019). The present findings suggest that enhancing the influence of CRH in this pathway may be a novel therapeutic strategy for OAB and nocturnal enuresis.…”

Section: Translational Relevancementioning

confidence: 48%

Corticotropin-Releasing Hormone from the Pontine Micturition Center Plays an Inhibitory Role in Micturition

et al. 2021

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Lower urinary tract or voiding disorders are prevalent across all ages and affect .40% of adults over 40 years old, leading to decreased quality of life and high health care costs. The pontine micturition center (PMC; i.e., Barrington's nucleus) contains a large population of neurons that localize the stress-related neuropeptide, corticotropin-releasing hormone (CRH) and project to neurons in the spinal cord to regulate micturition. How the PMC and CRH-expressing neurons in the PMC control volitional micturition is of critical importance for human voiding disorders. To investigate the specific role of CRH in the PMC, neurons in the PMC-expressing CRH were optogenetically activated during in vivo cystometry in unanesthetized mice of either sex. Optogenetic activation of CRH-PMC neurons led to increased intermicturition interval and voided volume, similar to the altered voiding phenotype produced by social stress. Female mice showed a significantly more pronounced phenotype change compared with male mice. These effects were eliminated by CRH-receptor 1 antagonist pretreatment. Optogenetic inhibition of CRH-PMC neurons led to an altered voiding phenotype characterized by more frequent voids and smaller voided volumes. Last, in a cyclophosphamide cystitis model of bladder overactivity, optogenetic activation of CRH-PMC neurons returned the voiding pattern to normal. Collectively, our findings demonstrate that CRH from PMC spinal-projecting neurons has an inhibitory function on micturition and is a potential therapeutic target for human disease states, such as voiding postponement, urinary retention, and underactive or overactive bladder.

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Section: Translational Relevancementioning

confidence: 48%

Corticotropin-Releasing Hormone from the Pontine Micturition Center Plays an Inhibitory Role in Micturition

et al. 2021

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“…Our findings are comparable to those of Girisgen et al who performed a study comprising 119 children with NE aged 5 to 16 years (79 girls and 40 boys) subdivided into monosymptomatic (49 children) and non‐monosymptomatic (70 children) patients and 40 healthy children as a control group. They observed a statistically significant difference in serum copeptin levels between children with NE and controls and between the monosymptomatic group and the control group 13 …”

Section: Discussionmentioning

confidence: 97%

“…They observed a statistically significant difference in serum copeptin levels between children with NE and controls and between the monosymptomatic group and the control group. 13 Szymanik-Grzelak et al reported a study comprising 25 children with PMNE and 20 healthy children that found no difference in serum copeptin levels between groups. 14 This finding is likely attributable to the small number of cases, particularly with normal urinary bladder capacity (13 children).…”

Section: Discussionmentioning

confidence: 97%

Correlation between serum copeptin and urinary aquaporin‐2 levels in children with primary monosymptomatic nocturnal enuresis

et al. 2023

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Objectives To determine the utility of serum copeptin and urinary aquaporin‐2 (AQP2) levels in diagnosing primary monosymptomatic nocturnal enuresis (PMNE) in children. Methods This study comprised 58 children (30 males and 28 females), aged 9.7 (±2.9) years with PMNE enuresis. Another 29 children (16 males and 13 females) aged 10.2 (±3.3) without nocturnal enuresis (NE) were recruited as a control group. History taking, clinical examination, and assessment of serum copeptin (blood) and AQP‐2 levels (urine) were performed in all participants. Results Serum levels of copeptin, potassium and urinary AQP‐2, and urine creatinine levels were lower in the PMNE group compared to the control group (p < 0.001 for all). No significant differences in body mass index, urine specific gravity, serum sodium, serum creatinine, or estimated glomerular filtration rate were observed between groups. This study evaluated both serum copeptin and AQP‐2 levels in healthy and enuretic children. Conclusions In this study, serum levels of copeptin (blood) and AQP2 (urine) were significantly lower in enuretic patients compared to healthy controls. Further, the measurement of urinary AQP‐2 levels is more practical than serum copeptin levels due to lower invasiveness.

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“…Nocturnal enuresis refers to involuntary urination during nighttime sleep in children after age 5 (1)(2)(3). These problems can cause social and psychological issues for children and their parents if left untreated (4,5).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Copeptin Level and Enuresis in Children Aged 5 - 15 Years

et al. 2023

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Background: Enuresis is bedwetting that occurs during sleep in children over five years old. If left untreated, it can lead to social and psychological problems for children and their parents. The role of copeptin in patients with primary monosymptomatic nocturnal enuresis (PMNE) has been reported in several studies. Due to the favorable structural properties of copeptin and the reflection of arginine vasopressin (AVP) concentration, it can be used as an alternative marker for AVP secretion. Objectives: This study aims to compare the levels of copeptin in healthy and enuresis children aged 5 - 15 years. Methods: This case-control study was performed on 42 children with primary monosymptomatic enuresis and 42 children without enuresis who were referred to the clinic of Taleghani hospital in Gorgan in 2020. Copeptin levels were measured by the enzyme-linked immunosorbent assay (ELISA) method. Results: Out of 84 patients, an equal proportion of girls (21 patients) and boys (21 patients) participated in both the case and control groups. The age of the children was 8.05 ± 2.46 years, and there was no statistically significant difference between the two groups (P = 0.16). The mean level of copeptin in the case and control groups were 6.7 ± 4.27 and 6.87 ± 8.52 pg/mL, respectively, significantly lower in the case group (P = 0.03). There was a statistically significant difference in the level of copeptin between the boys in the two groups (P = 0.03). Although the mean level of copeptin in the girls in the patient group was lower than that in the control group, this difference was not statistically significant (P = 0.35). Conclusions: In this study, the mean level of copeptin in PMNE was significantly lower than that in the control group, which suggests it may be considered as a probable biomarker for the prediction of response to treatment with desmopressin, but further study is required to confirm this hypothesis.

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Assessment of serum levels of copeptin and corticotropin-releasing factor in children with monosymptomatic and non-monosymptomatic nocturnal enuresis

Cited by 9 publications

References 15 publications

Corticotropin-Releasing Hormone from the Pontine Micturition Center Plays an Inhibitory Role in Micturition

Corticotropin-Releasing Hormone from the Pontine Micturition Center Plays an Inhibitory Role in Micturition

Correlation between serum copeptin and urinary aquaporin‐2 levels in children with primary monosymptomatic nocturnal enuresis

The Relationship Between Copeptin Level and Enuresis in Children Aged 5 - 15 Years

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