Land is an important resource that supports the production, life, and ecological development of human society. The current research on production–living–ecological space (PLES) is mainly focusing on the identification of single and dominant functions of land space, and the comprehensive spatial function measurement index of PLES (PLESI) is less known in the effective quantitative evaluation of multifunctionality of different land use categories. Integrating the CMIP6 (Coupled Model Intercomparison Project phase 6) scenario data and the future land use simulation model (FLUS), this research took the upper reaches of the Hanjiang River (URHR) as an example to explore the temporal and spatial variations in land use, PLES, and PLESIs during 2000–2020, and in the SSP2-4.5 and SSP5-8.5 scenarios from 2021 to 2100. The findings were as follows: (1) Forest land is the most widely distributed type of land; correspondingly, ecological space has the widest distribution area in PLES, followed by production space. (2) The area of dry land and building land increased between 2000 and 2010, accompanied by the increase in living space. From 2010 to 2020, the growth rate of building land tended to slow down while forest land increased, and the conflict of PLES eased. (3) The transfer between forest land and dry land is projected to intensify under the SSP2-4.5 scenario, while it is projected to occur between forest land and grassland under the SSP5-8.5 scenario. As for the changes in PLES, the SSP2-4.5 scenario has a greater impact than the SSP5-8.5 scenario. Spatially, several sub-basins in the northern URHR are the main areas of land use and PLES change. (4) PLESI presents a significant downward trend from 2000 to 2020 while trending upward under the SSP5-8.5 scenario and trending downward slightly under the SSP2-4.5 scenario between 2020 and 2100. Combining climate scenarios and the future land use simulation, this research would support the effective utilization of regional land resources and ecosystem management decision-making.