Assessment of Silver Nanoparticles Derived from Brown Algae Sargassum vulgare: Insight into Antioxidants, Anticancer, Antibacterial and Hepatoprotective Effect

Abstract

Algae are used as safe materials to fabricate novel nanoparticles to treat some diseases. Marine brown alga Sargassum vulgare are used to fabricate silver nanoparticles (Sv/Ag-NPs). The characterization of Sv/Ag-NPs was determined by TEM, EDX, Zeta potential, XRD, and UV spectroscopy. The Sv/Ag-NPs were investigated as antioxidant, anticancer, and antibacterial activities against Gram-positive bacteria Bacillus mojavensis PP400982, Staphylococcus caprae PP401704, Staphylococcus capitis PP402689, and Staphylococcus epidermidis PP403851. The activity of the Sv/Ag-NPs was evaluated as hepatoprotective in vitro in comparison with silymarin. The UV–visible spectrum of Sv/Ag-NPs appeared at 442 nm; the size of Sv/Ag-NPs is in range between 6.90 to 16.97 nm, and spherical in shape. Different concentrations of Sv/Ag-NPs possessed antioxidant, anticancer activities against (HepG-2), colon carcinoma (HCT-116), cervical carcinoma (HeLa), and prostate carcinoma (PC-3) with IC50 50.46, 45.84, 78.42, and 100.39 µg/mL, respectively. The Sv/Ag-NPs induced the cell viability of Hep G2 cells and hepatocytes treated with carbon tetrachloride. The Sv/Ag-NPs exhibited antibacterial activities against Staphylococcus caprae PP401704, Staphylococcus capitis PP402689, and Staphylococcus epidermidis PP403851. This study strongly suggests the silver nanoparticles derived from Sargassum vulgare showed potential hepato-protective effect against carbon tetrachloride-induced liver cells, and could be used as anticancer and antibacterial activities.

Phyto-synthesized silver nanoparticles from Sargassum subrepandum: anticancer, antimicrobial, and molluscicidal activities

“…This disruption can even extend to essential enzymes involved in the respiratory chain, which is achieved by destroying the plasma membranes of the microorganisms (Nisar et al, 2019). The antibacterial properties of silver nanoparticles generated by algae have been documented to be effective against Staphylococcus species and Proteus mirabilis, as reported by Hamouda and Aljohani (2024) and Rose et al (2024). This study examined the anti-cancer effects of phycosynthesized AgNPs against the MCF-7 breast cancer cell line.…”

Antifungal Activities of Biogenic Silver Nanoparticles Mediated by Marine Algae: In Vitro and In Vivo Insights of Coating Tomato Fruit to Protect against Penicillium italicum Blue Mold

“…Bioactive compounds derived from algae can help to synthesize nanoparticles and act as reducing, stabilizing, and coating agents, providing a robust coating on nanoparticles [19]. Silver nanoparticles synthesized by marine algae showed antibacterial and anticancer properties, and induced hepatoprotective effects in normal cells against C CL 4 [20]. Silver nanoparticles bio-fabricated by marine alga Ulva lactuca possessed antibacterial activities against some pathogenic bacteria [21].…”