2012
DOI: 10.1017/s0950268812002671
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Assessment of skin test with varicella-zoster virus antigen for predicting the risk of herpes zoster

Abstract: The Shozu Herpes Zoster (SHEZ) Study was designed to clarify the incidence of and predictive and immunological factors for herpes zoster in a defined community-based Japanese population. As part of this series, a total of 5683 residents aged ≥50 years received a varicella-zoster virus (VZV) skin test with VZV antigen, and 48 h later, the erythema and oedema were assessed by measuring the longest diameter. The diameters of both the erythema and oedema decreased with the increasing age of the subject. Sixty-thre… Show more

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Cited by 29 publications
(28 citation statements)
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“…A previous paper published by our research team showed that the average major axes of the erythema and edema induced by a intradermal skin test, both indices of VZV-specific cell mediated immunity, was smaller when the subjects were older, and that the incidences of HZ and PHN were higher when the average major axes of the erythema and edema were smaller. 5 Based on these findings, we were able to validate the hypothesis that the susceptibility to HZ and PHN increases with age because of weakened VZV-specific cell-mediated immunity. Many other studies have reported that VZV-specific cell-mediated immunity decreases with age.…”
Section: Discussionsupporting
confidence: 53%
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“…A previous paper published by our research team showed that the average major axes of the erythema and edema induced by a intradermal skin test, both indices of VZV-specific cell mediated immunity, was smaller when the subjects were older, and that the incidences of HZ and PHN were higher when the average major axes of the erythema and edema were smaller. 5 Based on these findings, we were able to validate the hypothesis that the susceptibility to HZ and PHN increases with age because of weakened VZV-specific cell-mediated immunity. Many other studies have reported that VZV-specific cell-mediated immunity decreases with age.…”
Section: Discussionsupporting
confidence: 53%
“…For subjects who wished to have their immune status measured, an intradermal skin test was conducted to measure VZV-specific cell-mediated immunity using the Varicella Skin Test Kit Antigen “Biken” (The Research Foundation for Microbial Diseases of Osaka University, Kagawa, Japan), 5 and blood tests were performed to measure VZV-specific cell-mediated immunity (enzyme-linked immunospot assay 6 ) and humoral immunity (neutralizing antibody, 7 glycoprotein-based enzyme-linked immunosorbent assay, 8 and immune adherence hemagglutination 8 ).…”
Section: Methodsmentioning
confidence: 99%
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“…This innate local resistance against VZV may also act as a checkpoint in HZ and delay the onset of eruption. Okuno et al . performed a large scale prospective cohort study (SHEZ study) and checked skin tests on subjects who had not had HZ before.…”
Section: Discussionmentioning
confidence: 99%
“…The clinical symptoms, as well as complementary investigations (blood tests, imaging and electrophysiology), determine the neurological complications. Detecting VZV by real-time polymerase chain reaction (RT-PCR) in skin lesions confirms HZ diagnosis [ 10 ], while detection of VZV deoxyribonucleic acid (DNA) in cerebrospinal fluid (CSF) by RT-PCR or identification of intrathecal antiviral antibodies [ 2 ], indicates extension of the infection to the nervous system [ 11 , 12 ]. Antiviral therapy is effective against VZV complications, specifically oral treatment (acyclovir or its pro-drug valacyclovir with better oral absorption) in benign cases and intravenous (IV) acyclovir for severe conditions such as ocular and central nervous system (CNS) complications, especially in immunosuppressed individuals [ 2 , 3 ].…”
Section: Introductionmentioning
confidence: 99%