Assessment of straylight and the modulation transfer function of intraocular lenses with centrally localized opacification associated with the intraocular injection of gas

Łabuz, Grzegorz; Yildirim, Timur M.; Berg, Thomas; Khoramnia, Ramin

doi:10.1016/j.jcrs.2018.01.033

Cited by 40 publications

(63 citation statements)

References 35 publications

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“…The optical performance of the IOLs was evaluated using the optical bench OptiSpheric IOL Pro II (Trioptics GmbH, Germany), as described in previous studies [13][14][15][16][17][18][19]. Its measurement principles adhere to the guidelines governed by the International Standard Organization (ISO) 11979-2 [20] and 11979-9 [21,22] and it thus includes a model cornea (spherical aberration: 0.28 μm) and a model eye containing a balanced salt solution with a refractive index of 1.336 at 25˚C.…”

Section: Optical Quality Evaluationmentioning

confidence: 99%

Ray propagation imaging and optical quality evaluation of different intraocular lens models

et al. 2020

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Ray propagation visualization and optical performance analysis of four different intraocular lenses (IOLs) Methods In this laboratory study, four IOLs with different optical designs were assessed: a monofocal AcrySof IQ SN60WF [Alcon], a diffractive-refractive bifocal AcrySof IQ Restor SN6AD1 [Alcon], a diffractive trifocal AcrySof IQ PanOptix TFNT00 [Alcon], and a diffractive extended-depth-of-focus (EDOF) Symfony ZXR00 [Johnson&Johnson]. An experimental setup with a water bath containing 0.01% fluorescein solution and monochromatic green laser light (532 nm) was used to visualize the propagation of light rays. Also, the optical performance of the IOLs was evaluated by measuring the modulation transfer function (MTF) values at a pupil sizes of 3.0 and 4.5 mm on the optical bench OptiSpheric ® IOL PRO II (Trioptics GmbH, Germany). Results Both the diffractive-refractive bifocal IOL and the EDOF IOL showed two defined foci for distance and near vision. In the diffractive trifocal IOL, three distinct foci for distance, intermediate, and near vision could be visualized. Conclusions The ray propagation visualization technique allows a qualitative assessment and comparison of light energy distribution between different IOL models. The measured Through-Focus Response (TFR) quantitatively confirmed the evaluated ray propagation behavior.

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Section: Optical Quality Evaluationmentioning

confidence: 99%

Ray propagation imaging and optical quality evaluation of different intraocular lens models

et al. 2020

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“…Łabuz et al show that there is a proportional relationship between straylight and the morphological parameters of the IOL opacification, that is, the area and density of sediment. This observation may explain the existing differences in the decreased optical quality between the affected patients that is independent of their visual acuity [21].…”

Section: Medical Backgroundmentioning

confidence: 87%

Physicochemical Analysis of Sediments Formed on the Surface of Hydrophilic Intraocular Lens after Descemet’s Stripping Endothelial Keratoplasty

et al. 2020

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An intraocular lens (IOL) is a synthetic, artificial lens placed inside the eye that replaces a natural lens that is surgically removed, usually as part of cataract surgery. The opacification of the artificial lens can be related to the formation of the sediments on its surface and could seriously impair vision. The physicochemical analysis was performed on an explanted hydrophilic IOL and compared to the unused one, considered as a reference IOL. The studies were carried out using surface sensitive techniques, which can contribute to a better understanding of the sedimentation process on hydrophilic IOLs’ surfaces. The microscopic studies allowed us to determine the morphology of sediments observed on explanted IOL. The photoelectron spectroscopy measurements revealed the presence of organic and inorganic compounds at the lens surface. Mass spectroscopy measurements confirmed the chemical composition of deposits and allowed for chemical imaging of the IOL surface. Applied techniques allowed to obtain a new set of information approximating the origin of the sediments’ formation on the surface of the hydrophilic IOLs after Descemet’s stripping endothelial keratoplasty.

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“…Pathogenetical classification: primary (type 1) (n=62) versus secondary (type 2) (n=13) The primarily opacified (type 1) IOLs are characterised by an opacification that occurs due to irregularities of the IOL material or the packaging of the IOL, mostly independent of patient characteristics. 5 The type 1 opacified IOLs of our set consisted of 62 (83%) IOLs and showed a fine-granular opacification pattern (table 3). Eighteen (29%) of the type 1 IOLs had previous interventions (1× intravitreal medical treatment (IVT), 18× YAG-laser posterior capsulotomy) and six (10%) were under continuous topical therapy.…”

Section: Overall Opacification (N=75)mentioning

confidence: 88%

Analysis of opacification patterns in intraocular lenses (IOL)

et al. 2021

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ObjectiveIntraocular lens (IOL) opacification may cause severe visual impairment. The pathogenesis remains unclear. The aim of this study was to analyse opacification patterns in different IOLs. Therefore, this multicentre, retrospective, observational study was conducted at Ludwig-Maximilians-University, Munich, Germany and University-Hospital Basel, Switzerland.Methods and analysisIn this study, 75 opacified IOLs were identified and classified after extraction. Macroscopical photo documentation, light and electron microscopic analysis were done.Results68 acrylic-hydrophilic single-piece-IOLs, 1 acrylic-hydrophilic 3-piece-IOL, 6 acrylic-hydrophobic 3-piece-IOLs were extracted. The dataset comprised IOLs known for opacification and IOLs not having been reported yet. 67 IOLs showed a fine-granular and 8 IOLs a crust-like opacification pattern. According to literature, 62 of the fine-granular opacified IOLs were graded into type 1 (processing/packaging-induced primary opacification) and 13 into type 2 (secondary opacification of unknown aetiology). The anterior surface of the IOLs was affected in all 75 IOLs, the posterior surface only in 23 cases. Of all 67 fine-granular IOLs, 43 had a central defect and 21 had a zone without opacification (clear islet).ConclusionIn our series, the morphology of IOL opacification did not follow the existing pathogenetic classification that strictly discriminates between primary and secondary causes. Fine-granular IOL opacification occurs with similar patterns in both type 1 and type 2 IOL opacification, while a crust-like pattern was only detected in type 2 IOL opacifications. Consequently, susceptibility of an IOL to opacification is caused by a multifactorial combination of material and processing properties as well as individual (pathological) conditions of the patient.

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Assessment of straylight and the modulation transfer function of intraocular lenses with centrally localized opacification associated with the intraocular injection of gas

Cited by 40 publications

References 35 publications

Ray propagation imaging and optical quality evaluation of different intraocular lens models

Ray propagation imaging and optical quality evaluation of different intraocular lens models

Physicochemical Analysis of Sediments Formed on the Surface of Hydrophilic Intraocular Lens after Descemet’s Stripping Endothelial Keratoplasty

Analysis of opacification patterns in intraocular lenses (IOL)

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