Assessment of Streptococcus mutans in healthy versus gingivitis and chronic periodontitis: A clinico-microbiological study

Dani, Sneha; Prabhu, Ashwin; Chaitra, K. R.; Desai, N. C.; Patil, Suvarna; Ranjan, Rajeev

doi:10.4103/0976-237x.194114

Cited by 57 publications

(46 citation statements)

References 22 publications

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“…A higher presence of S. mutans ( Figure 1) in patients with chronic moderate or severe periodontitis before extraction of teeth might derive from a lower oxygen tension within the periodontal pockets [10]. This is in accordance to studies by Cortelli et al [11] and Dani et al [12] who found a high proportion of this microorganism in subgingival plaque samples of chronic periodontitis patients.…”

Section: Discussionsupporting

confidence: 87%

Efficacy of citric acid on periodontal disease.

Al-Sharifi¹,

Alkaisy²,

Al-Mahmood³

2019

biomedicalresearch

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Background: The single most common primary etiological factor in periodontal disease is a bacterial plaque. Periodontitis affected root surface undergo physical and chemical damage that makes them a poor base for attachment and proliferation of fibroblast. Citric acid has a bacteriostatic effect and can cause root biomodification to remove the smear layer and expose root collagen fiber. Method: Forty swabs were taken from patients having periodontitis attended Al-Furat General hospital/ Dentistry department from August to November 2018. Each swab was taken around the tooth before and after tooth extraction. These swabs were cultured on blood and MacConkey agar plates. Different types of bacteria were isolated in the area of periodontitis. In addition, different concentrations of citric acid solution (0.3, 0.4, 0.5, 0.75 and 1 g/ml) were prepared and added to bacterial growth, and then the minimum inhibition zone was determined. Results: Four types of bacteria were isolated from the patient in the area of periodontitis: Streptococcus mutans, Escherichia coli, Staphylococcus aureus and anaerobic bacteria. No bacteria were isolated in the area after tooth extraction. Concentrations of the citric acid that showed the zone of inhibition on bacterial growth were 0.4, 0.5, 0.75, and 1 g/ml. Conclusion: Streptococcus mutans appeared at a high level in patients with periodontitis. The concentration of citric acid (0.4, 0.5, 0.75, 1 g/ml) was proved to inhibit the growth of bacteria in the smear area of diseased teeth; therefore, could be suggested to be used as a root conditioning agent.

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Section: Discussionsupporting

confidence: 87%

Efficacy of citric acid on periodontal disease.

Al-Sharifi¹,

Alkaisy²,

Al-Mahmood³

2019

biomedicalresearch

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“…mutans is located in the subgingival biofilm collected from both patients with healthy gingival condition and with periodontal disease. However, the behavior of the bacteria, such as sucrose consumption, acid, and glycan production, was different (Dani et al, 2016). S .…”

Section: Introductionmentioning

confidence: 99%

Comparison of biofilm formation and migration of Streptococcus mutans on tooth roots and titanium miniscrews

Laosuwan

Epasinghe

et al. 2018

Clinical & Exp Dental Res

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Periodontitis and peri‐implantitis are inflammatory diseases caused by periodontal pathogenic bacteria leading to destruction of supporting periodontal/peri‐implant tissue. However, the progression of inflammatory process of these two diseases is different. The bacterial biofilm is the source of bacteria during the inflammatory process. As the bacteria migrate down the surface of tooth or titanium implant, the inflammation spreads along with it. Streptococcus mutans has an important role in oral bacterial biofilm formation in early stage biofilm before the microbiota shift to late stage and become more virulent. The other major difference is the existence of periodontal ligament (PDL) cells in normal teeth but not in peri‐implant tissue. This study aims to compare the S. mutans bacterial biofilm formation and migration on 2 different surfaces, tooth root and titanium miniscrew. The biofilm was grown with a flow cells system to imitate the oral dynamic system with PDL cells. The migration distances were measured, and the biofilm morphology was observed. Data showed that the biofilm formation on miniscrew was slower than those on tooth root at 24 hr. However, there were no difference in the morphology of the biofilm formed on the tooth root with those formed on the miniscrew at both 24 and 48 hr. The biofilm migration rate was significantly faster on miniscrew surface compare with those on tooth root when observe at 48 hr (p < .001). There are no significant differences in biofilm migration within miniscrew group and tooth root group despite the exiting of PDL cell (p > .05). The biofilm's migration rate differences on various surfaces could be one of the factors accounting for the different inflammatory progression between periodontitis and peri‐implantitis disease.

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“…(2012) discovered the presence of P. endodontalis is associated with chronic periodontitis. Dani et al (2016) found that S. mutans is considered to be one of the major pathogens in dental caries and is very likely to induce periodontal disease. A molecular survey by Griffen revealed new species Filifactor alocis is strongly associated with periodontal disease (Griffen et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Zero‐inflated Poisson factor model with application to microbiome read counts

Demmer

2020

Biometrics

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Dimension reduction of high-dimensional microbiome data facilitates subsequent analysis such as regression and clustering. Most existing reduction methods cannot fully accommodate the special features of the data such as count-valued and excessive zero reads. We propose a zero-inflated Poisson factor analysis (ZIPFA) model in this article. The model assumes that microbiome absolute abundance data follow zeroinflated Poisson distributions with library size as offset and Poisson rates negatively related to the inflated zero occurrences. The latent parameters of the model form a low-rank matrix consisting of interpretable loadings and low-dimensional scores which can be used for further analyses. We develop an efficient and robust expectationmaximization (EM) algorithm for parameter estimation. We demonstrate the efficacy of the proposed method using comprehensive simulation studies. The application to the Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS) provides valuable insights into the relation between subgingival microbiome and periodontal disease.

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Assessment of Streptococcus mutans in healthy versus gingivitis and chronic periodontitis: A clinico-microbiological study

Cited by 57 publications

References 22 publications

Efficacy of citric acid on periodontal disease.

Efficacy of citric acid on periodontal disease.

Comparison of biofilm formation and migration of Streptococcus mutans on tooth roots and titanium miniscrews

Zero‐inflated Poisson factor model with application to microbiome read counts

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