Assessment of stress patterns on a spinal motion segment in healthy versus osteoporotic bony models with or without disc degeneration: a finite element analysis

Tsouknidas, Alexander; Sarigiannidis, Stylianos Orestis; Anagnostidis, Kleovoulos; Michailidis, Nikolaos; Ahuja, Sashin

doi:10.1016/j.spinee.2014.12.148

Cited by 44 publications

(34 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering that Chinese and Korean studies focus on Asian populations, this data can be used as a reference in studies including Chinese population, indicating that the relationship between the higher risk of ASD in women may be connected with a higher incidence of osteoporosis. Published studies have reported that osteoporosis may increase the risk of disc degeneration in the lumbar spine by adversely changing the loading pattern and intradiscal pressure [29, 30]. We therefore hypothesize that osteoporosis is a key reason for the relatively higher risk of ASD in women.…”

Section: Discussionmentioning

confidence: 88%

Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy

Wang

Zhang

et al. 2019

J Orthop Surg Res

View full text Add to dashboard Cite

Study design Variation in the biomechanical characteristics of intervertebral discs adjacent to the segment disc after undergoing percutaneous transforaminal endoscopic discectomy (PTED) in models with normal and abnormal bone mineral density (BMD) was estimated using the finite element method. Objective The study investigated the change in the incidence of adjacent segment disease (ASD) after PTED in patients without and with osteoporosis. Backgrounds PTED has been widely used for treating lumbar disc herniation (LDH); changes in BMD will affect biomechanical characteristics, possibly leading to changes in the incidence of ASD after PTED. However, this issue remains largely unclear. Methods A non-linear, lumbosacral finite element model was reconstructed based on imaging data and validated using compared values computed by the current model from published and well-validated, in vitro biomechanical experiment studies. Corresponding PTED models with normal and abnormal BMDs were also reconstructed. Shear and von Mises stresses on the annulus fibrosis, the von Mises stress on the endplates in L5–S1 segment discs, and the total deformation of current lumbosacral models were computed in different body positions by changing loading conditions, including flexion, extension, left and right lateral bending, and axial rotation. Results In most loading conditions, biomechanical characteristics of the lumbosacral segment discs with normal BMDs after PTED slightly increased. However, in the PTED model with osteoporosis, most of the biomechanical characteristics dramatically increased. Conclusion Osteoporosis leads to the deterioration of biomechanical characteristics in the adjacent segment disc after PTED; this variation may also result in an increase in the incidence of ASD. However, further studies on the interactions between pathological changes are warranted.

show abstract

Section: Discussionmentioning

confidence: 88%

Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy

Wang

Zhang

et al. 2019

J Orthop Surg Res

View full text Add to dashboard Cite

show abstract

“…A few studies have considered bone anisotropy or orthotropy in their spine models, but have assumed a constant cortical thickness over the whole vertebrae. [18][19][20] Whereas, other studies have assumed homogenous isotropic bone model for the lumbar spine. 10,14,21 An experimental study by Mosekilde et al 22 reported a highly significant positive correlation (p \ 0.01) in both vertical and horizontal directions between the biomechanical properties and ash density.…”

Section: Introductionmentioning

confidence: 99%

Numerical analysis of the mechanical behaviour of intact and implanted lumbar functional spinal units: Effects of loading and boundary conditions

Talukdar

Mukhopadhyay

Dhara

et al. 2021

Proc Inst Mech Eng H

View full text Add to dashboard Cite

The objective of this study was to develop an improved finite element (FE) model of a lumbar functional spinal unit (FSU) and to subsequently analyse the deviations in load transfer owing to implantation. The effects of loading and boundary conditions on load transfer in intact and implanted FSUs and its relationship with the potential risk of vertebral fracture were investigated. The FE models of L1-L5 and L3-L4 FSUs, intact and implanted, were developed using patient-specific CT-scan dataset and segmentation of cortical and cancellous bone regions. The effect of submodelling technique, as compared to artificial boundary conditions, on the elastic behaviour of lumbar spine was examined. Applied forces and moments, corresponding to physiologic movements, were used as loading conditions. Results indicated that the loading and boundary conditions considerably affect stress-strain distributions within a FSU. This study, based on an improved FE model of a vertebra, highlights the importance of using the submodelling technique to adequately evaluate the mechanical behaviour of a FSU. In the intact FSU, strains of 200–400 µε were observed in the cancellous bone of vertebral body and pedicles. High equivalent stresses of 10–25 MPa and 1–5 MPa were generated around the pars interarticularis for cortical and cancellous regions, respectively. Implantation caused reductions of 85%–92% in the range of motion for all movements. Insertion of the intervertebral cage resulted in major deviations in load transfer across a FSU for all movements. The cancellous bone around cage experienced pronounced increase in stresses of 10–15 MPa, which indicated potential risk of failure initiation in the vertebra.

show abstract

“…Availability of powerful computational resources and advances in image-based geometrically and materially personalized FEM50,51 offers a unique research platform for study of lower back load in patients with LBP, particularly when patients have pathological conditions known to affect low back load. For example, Tsouknidas et al52 applied FEM to simulate healthy and osteoporotic lumbosacral spine and found that osteoporosis led to increased facet joint load and even more pronounced with coexistence of degenerated disk. Currently, there is no report considering comorbidity when analyzing low back load in patients with LBP.…”

Section: Kinetic Methods In Estimating Lower Back Loadsmentioning

confidence: 99%

Application of advanced biomechanical methods in studying low back pain – recent development in estimation of lower back loads and large-array surface electromyography and findings

Bazrgari¹,

Xia²

2017

JPR

View full text Add to dashboard Cite

Low back pain (LBP) is a major public health problem and the leading disabling musculoskeletal disorder globally. A number of biomechanical methods using kinematic, kinetic and/or neuromuscular approaches have been used to study LBP. In this narrative review, we report recent developments in two biomechanical methods: estimation of lower back loads and large-array surface electromyography (LA-SEMG) and the findings associated with LBP. The ability to estimate lower back loads is very important for the prevention and the management of work-related low back injuries based on the mechanical loading model as one category of LBP classification. The methods used for estimation of lower back loads vary from simple rigid link-segment models to sophisticated, optimization-based finite element models. In general, reviewed reports of differences in mechanical loads experienced in lower back tissues between patients with LBP and asymptomatic individuals are not consistent. Such lack of consistency is primarily due to differences in activities under which lower back mechanical loads were investigated as well as heterogeneity of patient populations. The ability to examine trunk neuromuscular behavior is particularly relevant to the motor control model, another category of LBP classification. LA-SEMG not only is noninvasive but also provides spatial resolution within and across muscle groups. Studies using LA-SEMG showed that healthy individuals exhibit highly organized, symmetric back muscle activity patterns, suggesting an orderly recruitment of muscle fibers. In contrast, back muscle activity patterns in LBP patients are asymmetric or multifocal, suggesting lack of orderly muscle recruitment. LA-SEMG was also shown capable of capturing unique back muscle response to manual therapy. In conclusion, estimation of low back load and LA-SEMG techniques demonstrated promising potentials for understanding LBP and treatment effects. Future studies are warranted to fully establish clinical validity of these two biomechanical methods.

show abstract

Assessment of stress patterns on a spinal motion segment in healthy versus osteoporotic bony models with or without disc degeneration: a finite element analysis

Cited by 44 publications

References 21 publications

Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy

Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy

Numerical analysis of the mechanical behaviour of intact and implanted lumbar functional spinal units: Effects of loading and boundary conditions

Application of advanced biomechanical methods in studying low back pain – recent development in estimation of lower back loads and large-array surface electromyography and findings

Contact Info

Product

Resources

About

Assessment of stress patterns on a spinal motion segment in healthy versus osteoporotic bony models with or without disc degeneration: a finite element analysis

Cited by 44 publications

References 21 publications

Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy

Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy

Numerical analysis of the mechanical behaviour of intact and implanted lumbar functional spinal units: Effects of loading and boundary conditions

Application of advanced biomechanical methods in studying low back pain &ndash; recent development in estimation of lower back loads and large-array surface electromyography and findings

Contact Info

Product

Resources

About

Application of advanced biomechanical methods in studying low back pain – recent development in estimation of lower back loads and large-array surface electromyography and findings