Earthquakes can cause serious damage to buildings, roads and other infrastructure. The large amount of dust and particulate matter generated when these structures collapse and are damaged can quickly enter the air, leading to a decline in air quality. At the same time, earthquakes may cause secondary disasters such as fires and landslides, which will also produce large amounts of soot and particulate matter, which will have a negative impact on air quality. Therefore, earthquake disaster risk assessment studies are carried out to identify potentially hazardous areas and facilities in advance in order to reduce the air pollution problems that may be caused by earthquakes. Existing research on earthquake disaster risk assessment mainly evaluates earthquake risk from the perspective of geology or seismology, but there are few studies based on multidisciplinary assessment that integrates geology, seismology, engineering and social sciences into socioeconomic factors. To this end, based on remote sensing and GIS technology, this paper takes Qinghai Province, a seismically active area, as the research area, and integrates land use data, natural environment data, social environment data and seismic parameter zoning data to construct a comprehensive assessment model for earthquake disaster vulnerability and risk. The results showed that there were 5 very high-risk areas, 7 high-risk areas, 10 medium-risk areas, 11 low-risk areas and 12 very low-risk areas in Qinghai Province. The high-risk areas are mainly distributed in the central and western parts of Qinghai Province, where the earthquake breeding environment is sufficient, the scale of active faults is huge and the adaptability of the carrier is low. The results of an earthquake disaster risk assessment can provide a reference for the government to formulate environmental protection policies. According to the assessment results, the government can formulate targeted measures to strengthen air pollution control and improve air quality.