Assessment of sudomotor function in hypertensive with/without type-2 diabetes patients using SUDOSCAN: An electrophysiological study

Hussein, Ismail I.; Alshammary, Safaa Hussein Ali; Al-Nimer, Marwan S.M.

doi:10.1016/j.cnp.2020.12.001

Cited by 10 publications

(6 citation statements)

References 39 publications

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“…In addition, the authors demonstrated an association between the presence of peripheral nerve impairment detected by Sudoscan and the risk of developing hypertension and cardiac autonomic neuropathy. For this reason, the authors hypothesized that the capability of Sudoscan in detecting the impairment of peripheral autonomic fibers could also be useful as a prognostic indicator of cardiac autonomic damage [ 114 ].…”

Section: Diagnosismentioning

confidence: 99%

Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options

Galiero

Caturano

Vetrano

et al. 2023

IJMS

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Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis for type 2 diabetes mellitus (T2DM), while it appears in subjects with type 1 diabetes mellitus (T1DM) almost 10 years after the onset of the disease. The impairment can involve both somatic fibers of the peripheral nervous system, with sensory-motor manifestations, as well as the autonomic system, with neurovegetative multiorgan manifestations through an impairment of sympathetic/parasympathetic conduction. It seems that, both indirectly and directly, the hyperglycemic state and oxygen delivery reduction through the vasa nervorum can determine inflammatory damage, which in turn is responsible for the alteration of the activity of the nerves. The symptoms and signs are therefore various, although symmetrical painful somatic neuropathy at the level of the lower limbs seems the most frequent manifestation. The pathophysiological aspects underlying the onset and progression of DN are not entirely clear. The purpose of this review is to shed light on the most recent discoveries in the pathophysiological and diagnostic fields concerning this complex and frequent complication of diabetes mellitus.

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Section: Diagnosismentioning

confidence: 99%

Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options

Galiero

Caturano

Vetrano

et al. 2023

IJMS

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“…In our study, a generalized modification of group IV (small, non-myelinated) C fiber that are afferent stimuli of the exercise pressor reflex is suggested by the result of electrochemical skin conductance study in CA-TTR patients. Sudoscan ® is a non-invasive technology that assesses function of C-small sympathetic nerve fibers of the sweat gland via determination of chloride conductance across the skin ( Mayaudon et al, 2010 ; Casellini et al, 2013 ; Hussein et al, 2021 ; Kharoubi et al, 2021 ). Low electrochemical skin conductance values have been associated with global and heart sympathetic impairment and proven to identify patients at risk of major adverse cardiovascular event ( Mayaudon et al, 2010 ; Casellini et al, 2013 ; Hussein et al, 2021 ; Kharoubi et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Sudoscan ® test results are provided as hands (hESC) and feet (fESC) conductance (mean of left and right side). Sudomotor function was considered normal with values of hESC above 60 μS and/or fESC above 70 μS ( Mayaudon et al, 2010 ; Casellini et al, 2013 ; Hussein et al, 2021 ; Kharoubi et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

The ventilatory component of the muscle metaboreflex is overstimulated in transthyretin cardiac amyloidosis patients with poor aerobic capacity

et al. 2023

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Background: The exercise pressor reflex, i.e., metabo- and mechano-reflex, partially regulates the control of ventilation and cardiovascular function during exercise. Abnormal exercise pressor reflex response has been associated with exaggerated ventilatory drive, sympathovagal imbalance and exercise limitation in chronic heart failure patients. Whether metaboreflex is over-activated and participate to poor aerobic capacity in patients with hereditary transthyretin cardiac amyloidosis (CA-TTR) is unknown.Methods: Twenty-two CA-TTR patients (aged 76 ± 7, 68% male) with the V122I (p.Val142Ile) transthyretin underwent a thorough evaluation including heart rate variability metrics, electrochemical skin conductance (ESC), physical function cardiopulmonary exercise testing, and muscle metaboreflex assessment. Eleven control subjects were chosen for muscle metaboreflex assessment.Results: Age-matched controls (n = 11) and CA-TTR patients (n = 22) had similar metaboreflex sensitivity for heart rate, stroke volume, cardiac index and mean systemic arterial pressure. Compared with age-matched controls, metaboreflex sensitivity for systemic vascular resistance (−18.64% ± 6.91% vs 3.14% ± 23.35%) and minute-ventilation responses (−9.65% ± 14.83% vs 11.84% ± 23.1%) was markedly increased in CA-TTR patients. Values of ESC displayed positive correlations with stroke volume (r = 0.53, p = 0.011) and cardiac index (r = 0.51, p = 0.015) components of metaboreflex sensitivity, an inverse correlation with systemic vascular resistance (r = −0.55, p = 0.008) and a trend with mean arterial (r = −0.42, p = 0.052) components of metaboreflex sensitivity. Peak aerobic capacity (peak VO2%) displayed an inverse correlation with the ventilation component of metaboreflex sensitivity (r = −0.62, p = 0.015).Conclusion: Consistent with the “muscle hypothesis” in heart failure, it is proposed that deterioration of skeletal muscle function in hereditary CA-TTR patients may activate muscle metaboreflex, leading to an increase in ventilation and sensation of breathlessness, the perception of fatigue, and overall sympathetic activation.

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“…This is because the tool has the advantage of providing a rapid, non-invasive, simple, convenient, objective, and quantitative evaluation of the function of the peripheral small nerve fiber, making it applicable for detecting sweat nerve fiber dysfunction. 19 Furthermore, the tool offers a potentially reliable method for detecting autonomic nerve dysfunction and could assist in the early detection of skin dryness and ulcers caused by sweat dysfunction. 20 The resulting preventive treatment would potentially reduce or delay disease progression and any related complications, such as lower extremity ulcers and amputations.…”

Section: Discussionmentioning

confidence: 99%

Consistency Analysis Between SUDOSCAN Examinations and Electromyography Results in Patients with Diabetes

Zhao¹,

Bao²,

Ye³

et al. 2022

DMSO

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Objective To evaluate the consistency between SUDOSCAN examinations and electromyography (EMG) results in patients with diabetes. Methods A total of 326 patients with diabetes (201 males and 125 females) who were hospitalized in the endocrinology ward of the Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine) from June 2020 to February 2021 were selected as participants. All the patients were tested using a SUDOSCAN conductance analyzer for electrical skin conductivities and EMG for nerve conduction. The differences and consistencies between the results of the two examinations were analyzed. McNemar’s test was used to analyze the differences between the results, and Cohen’s kappa test was utilized to test the consistencies. Results A total of 174 patients had abnormal SUDOSCAN results, and 152 patients had normal SUDOSCAN results. The EMG results of 299 patients were abnormal, and the EMG results of 27 patients were normal. The McNemar test result was P = 0.000, and the differences between the results of the SUDOSCAN and EMG examinations were statistically significant ( P < 0.01). No significant consistency was found between the SUDOSCAN and EMG results, meaning that the consistency between the two examination results was not statistically significant ( P = 0.868, P > 0.05). The difference between the results was statistically significant ( P < 0.05), and the consistency was poor (kappa = 0.005). Conclusion Differences existed between the SUDOSCAN examination and EMG results, and the results of the two examination methods were inconsistent, indicating that SUDOSCAN examinations cannot replace EMG examinations for DSPN.

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Assessment of sudomotor function in hypertensive with/without type-2 diabetes patients using SUDOSCAN: An electrophysiological study

Cited by 10 publications

References 39 publications

Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options

Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options

The ventilatory component of the muscle metaboreflex is overstimulated in transthyretin cardiac amyloidosis patients with poor aerobic capacity

Consistency Analysis Between SUDOSCAN Examinations and Electromyography Results in Patients with Diabetes

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