Assessment of suicidal behavior in dermatology (Review)

Stănescu, Ana Maria Alexandra; Totan, Alexandra Ripszky; Mircescu, Daniela; Diaconescu, Smaranda; Bratu, Ovidiu Gabriel; Fekete, László; Fekete, Gyula László; Boda, Daniel; Diaconu, Camelia Cristina

doi:10.3892/etm.2019.8145

Cited by 11 publications

(9 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…And adults with vitiligo have increased hospitalization for mental health disorders [20]. Other psychosocial problems consist of fear, shame, insecurity, sadness, and hopeless, which could induce low self-esteem, social isolation, or even suicidal ideation [5,21,22]. These negative psychosocial impacts of vitiligo can extend into the families [23].…”

Section: Disease Burden and Epidemiologymentioning

confidence: 99%

Clinical Features, Immunopathogenesis, and Therapeutic Strategies in Vitiligo

Wang

2021

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Vitiligo is an autoimmune disease of the skin characterized by epidermal melanocyte loss resulting in white patches, with an approximate prevalence of 0.5-2% worldwide. Several precipitating factors by chemical exposure and skin injury present commonly in patients with vitiligo. Although the diagnosis appears to be straightforward for the distinct clinical phenotype and specific histological features, vitiligo provides many challenges including chronicity, treatment resistance, frequent relapse, associated profound psychosocial effect, and negative impact on quality of life. Multiple mechanisms are involved in melanocyte disappearance, including genetics, environmental factors, and immune-mediated inflammation. Compelling evidence supports the melanocyte intrinsic abnormalities with poor adaptation to stressors leading to instability and release of danger signals, which will activate dendritic cells, natural killer cells, and innate lymphoid cells to initiate innate immunity, ultimately resulting in T-cell mediated adaptive immune response and melanocyte destruction. Importantly, the cross-talk between keratinocytes, melanocytes, and immune cells, such as interferon (IFN)-γ signaling pathway, builds inflammatory loops that give rise to the disease deterioration. Improved understanding of the immune pathogenesis of vitiligo has led to the development of new therapeutic options including Janus kinase (JAK) inhibitors targeting IFN-γ signaling pathways, which can effectively reverse depigmentation. Furthermore, definition of treatment goals and integration of comorbid diseases into vitiligo management have revolutionized the way vitiligo is treated. In this review, we highlight recent developments in vitiligo clinical aspects and immune pathogenesis. Our key objective is to raise awareness of the complexity of this disease, the potential of prospective therapy strategies, and the need for early and comprehensive management.

show abstract

Section: Disease Burden and Epidemiologymentioning

confidence: 99%

Clinical Features, Immunopathogenesis, and Therapeutic Strategies in Vitiligo

Wang

2021

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

show abstract

“…Dysregulation of serotonin transmission in the CNS (central nervous system) is reported to be related to different psychiatric disorders in humans, including depression, impulsive aggression and anxiety disorders (42)(43)(44). In depression, depletion of serotonin is linked to aggression, facilitating suicide or self-mutilation.…”

Section: Discussionmentioning

confidence: 99%

Genital self‑mutilation: A challenging pathology (Review)

et al. 2021

Self Cite

View full text Add to dashboard Cite

Genital self-mutilation is a pathology that leads to numerous and important discussions, rarely presented in the medical literature. There have been many attempts to explain the reasons behind these medical phenomena, but single cases have been generally reported, making it extremely difficult to draw valid conclusions. It is acknowledged that there are psychotic and non-psychotic causes, from psychiatric problems and sexual identity disorders to cultural or religious reasons, alcohol or recreational drug consumption, unconventional types of sexual satisfaction or self-satisfaction. Recent theories consider self-mutilation as a phenomenon of reducing distress or tension, as an expression of feelings of anger or sorrow. It is believed that 55-85% of those who have resorted to self-mutilation have at least once in their life tried to commit suicide. There is evidence that early discovery and intervention as well as proper treatment in regards to psychosis can significantly reduce the number of self-mutilation episodes, with a protective role of these individuals. Cases of genital self-mutilation may be considered real medical emergencies, sometimes extremely challenging and accompanied by severe complications. Injury of the genital area is usually accompanied by numerous early or long-term complications due to the marked vascular area and to the microbial flora present in this part of the body. The degree of mutilation is an unforeseen aspect that the medical staff may have to encounter during the intervention, sometimes testing their imagination and surgical skills when dealing with such a case. Understanding the causes of these self-aggressive behaviors, which may be life-threatening, is critical and multidisciplinary mobilization is needed after treatment of the acute phases. The outcome of these patients depends on integrated collaborative work. These cases represent a serious reason for frustration for the physicians involved in solving them, and knowledge of these issues is valuable to urologists, psychiatrists and other health professionals.

show abstract

“…Vitiligo is a psychologically devastating skin disease, and it is associated with depression, stress, fear, shame, insecurity, sadness, and low self-esteem, which could lead to social isolation or even suicidal ideation [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Vitiligo: Pathogenesis, Clinical Features, and Treatment

Acar¹

2023

Pigmentation Disorders - Etiology and Recent Advances in Treatments

View full text Add to dashboard Cite

Vitiligo is a depigmenting skin disorder of unknown etiology, which presents with nonscaly, chalky-white macules. Selective loss of melanocytes is the characteristic feature of vitiligo. Of the many theories proposed for melanocyte loss, convergence theory, which suggests that the combination of biochemical, environmental, and immunological factors play a role in the pathophysiology of vitiligo, is currently the most accepted theory. Treatment options include topical and systemic immunosuppressants, phototherapy, and surgical techniques. The subtype, extent, distribution, and activity of disease are the determining factors for treatment choice. In this chapter, the pathogenesis, clinical features of vitiligo, and treatment options are discussed.

show abstract

Assessment of suicidal behavior in dermatology (Review)

Cited by 11 publications

References 40 publications

Clinical Features, Immunopathogenesis, and Therapeutic Strategies in Vitiligo

Clinical Features, Immunopathogenesis, and Therapeutic Strategies in Vitiligo

Genital self‑mutilation: A challenging pathology (Review)

Vitiligo: Pathogenesis, Clinical Features, and Treatment

Contact Info

Product

Resources

About