Assessment of the abuse liability of three menthol Vuse Solo electronic cigarettes relative to combustible cigarettes and nicotine gum

Stiles, Mitchell F.; Campbell, Leanne R.; Jin, Tao; Graff, Donald W.; Fant, Reginald V.; Henningfield, Jack E.

doi:10.1007/s00213-018-4904-x

Cited by 29 publications

(51 citation statements)

References 26 publications

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“…‘dizziness’ and ‘nausea’ items comprising the ‘aversion’ subscale of the mCEQ) relative to e‐cigarettes. Similarly, other research has shown that rewarding subjective effects are greater from cigarettes relative to e‐cigarettes following ad‐libitum use and in qualitative interviews . Although nicotine exposure was greater from cigarettes, there was no difference in overall withdrawal symptoms measured by the MNWS.…”

Section: Discussionsupporting

confidence: 49%

“…Similar to de‐nicotinized cigarettes , e‐cigarettes without nicotine can reduce tobacco withdrawal symptoms, but less so than nicotine‐containing e‐cigarettes . However, e‐cigarettes containing nicotine are reported not to reduce withdrawal symptoms as much as cigarettes —perhaps because nicotine delivery is not the only factor in managing cigarette withdrawal symptoms. Differences between e‐cigarette types can affect stimulus characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Twenty‐four‐hour subjective and pharmacological effects of ad‐libitum electronic and combustible cigarette use among dual users

et al. 2020

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Background and Aims Relative pharmacological effects of e-cigarettes and cigarettes during 24 hours of ad-libitum use have not been described. In this study, 24-hour blood plasma nicotine concentrations and 48-hour subjective effects with use of cigarettes and e-cigarettes were measured among dual users. Design Two-arm within-subject cross-over design with preferred e-cigarette or cigarette ad-libitum use over 48 hours. Setting Hospital research ward in San Francisco, California, USA. Participants Thirty-six healthy dual users of e-cigarettes and cigarettes (n = 8, 25% females). Measurements Twenty-four-hour blood plasma nicotine and cotinine concentrations and 48-hour self-reported nicotine withdrawal symptoms and rewarding effects. Findings Analyses used analysis of variance (ANOVA)-based mixed models with order of product (e-cigarette or cigarette) and product type (combustible cigarette or type of e-cigarette) as fixed effects, and subject as a repeated effect. During a 24-hour period, e-cigarettes produced lower nicotine exposure than cigarettes for the majority of users, although 25% received more nicotine from e-cigarettes, which was predicted by more frequent e-cigarette use or greater dependence. Compared to cigarette smoking, nicotine exposure for variable-power tank users was similar, while cig-a-like (t (30) = 2.71, P = 0.011, d = 0.745) and fixed-power tank users (t (30) = 3.37, P = 0.002, d = 0.993) were exposed to less nicotine. Cigarettes were rated higher than e-cigarettes on some desirable subjective effects (e.g. psychological reward, t (322) = 7.24 P < 0.001, d = 0.432), but withdrawal symptom reduction was comparable. No differences were found between e-cigarette types, but Bayes factors indicate that these measures were insensitive.Conclusions During a 24-hour period in a hospital setting in the United States, nicotine exposure for dual users of ecigarettes and cigarettes was similar when using cigarettes or variable-power tank devices only but was lower for those using cig-a-like or fixed-power devices only. Despite lower nicotine levels, all types of e-cigarette were effective in preventing withdrawal symptoms. E-cigarettes were rated less rewarding than cigarettes.

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Twenty‐four‐hour subjective and pharmacological effects of ad‐libitum electronic and combustible cigarette use among dual users

et al. 2020

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“…The pharmacological effects of nicotine are purported to drive these associations, as nicotine has detrimental effects on the neurotransmitters that regulate the sleep–wake cycle (Sabanayagam & Shankar, ; Zhang, Samet, Caffo, & Punjabi, ). Given this proposed mechanism, nicotinized e‐cigarettes, which deliver cigarette‐like levels of nicotine (Goniewicz, Kuma, Gawron, Knysak, & Kosmider, ; Ramôa et al., ; Stiles et al., ; Wagener et al., ), may also be linked to poor sleep health. However, the effects of e‐cigarette use on sleep health remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Electronic cigarette use and sleep health in young adults

Brett

Miller

Leavens

et al. 2019

Journal of Sleep Research

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Poor sleep health is associated with numerous health concerns, and sleep problems are exacerbated by cigarette smoking. Although rates of traditional tobacco use are declining, rates of electronic cigarette (e-cigarette) use are comparatively high and growing. Given that nicotine is a primary mechanism by which smoking negatively impacts sleep health, e-cigarette use may also be linked to poor sleep health; however, no research has investigated this association. Participants were 1,664 college students, 40.9% of whom reported ever trying or currently using an e-cigarette. Questionnaires assessed demographic information, sleep health and e-cigarette use status and patterns. All measures were completed remotely via a secure online survey. Analysis of covariance was used to compare the sleep health of daily/non-daily e-cigarette users to (a) non-users and (b) users of combustible cigarettes. Gender and drinks per week were included as covariates in analyses. Current combustible and e-cigarette users reported significantly more sleep difficulties than never users.Users of e-cigarettes reported greater use of sleep medication than combustible cigarette users. Similar to combustible cigarette smoking, e-cigarette use (vs. nonuse) was associated with worse sleep health, even among non-daily e-cigarette users.These findings may indicate a need for assessment of and education on the role of e-cigarette use in sleep health among individuals who report experimentation with or current use of e-cigarettes. Future research should examine these relationships prospectively. K E Y W O R D Scollege students, ENDS, insomnia, nicotine, sleep quality

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“…Drug Alcohol Depend [ 30 ] 60 60 30 (50.0 %) 0 (0.0 %) Stiles, et al, (2018). Psychopharmacology [ 31 ] 220 220 220 220 2019 Hiler, et al, (2019). Experimental and Clinical Psychopharmacology [ 32 ] 256 224 (87.5 %) 128 (50.0 %) 0 (0.0 %) O'Connell, et al, (2019).…”

Section: Resultsmentioning

confidence: 99%

Nicotine pharmacokinetics of electronic cigarettes: A pooled data analysis from the literature

et al. 2021

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Assessment of the abuse liability of three menthol Vuse Solo electronic cigarettes relative to combustible cigarettes and nicotine gum

Cited by 29 publications

References 26 publications

Twenty‐four‐hour subjective and pharmacological effects of ad‐libitum electronic and combustible cigarette use among dual users

Twenty‐four‐hour subjective and pharmacological effects of ad‐libitum electronic and combustible cigarette use among dual users

Electronic cigarette use and sleep health in young adults

Nicotine pharmacokinetics of electronic cigarettes: A pooled data analysis from the literature

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