Assessment of the allergenic potential of foods derived from genetically engineered crop plants*

Metcalfe, Dean D.; Astwood, James D.; Townsend, R.; Sampson, Hugh A.; Taylor, Steve L.; Fuchs, Roy L.

doi:10.1080/10408399609527763

Cited by 382 publications

(296 citation statements)

References 82 publications

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“…However, Hileman et al [128] concluded that a threshold of six amino acids will not distinguish allergenic from non-allergenic proteins and will result in a large number of false positives. He instead recommended a minimum threshold of eight amino acids which is consistent with the International Life Science Institute/ Institute of Food Biotechnology Council (ILSI/IFBC) recommendations in 1996 in their decision tree approach which has been adopted internationally by GM food evaluators [129].…”

Section: Food Safetymentioning

confidence: 99%

Recent advances in the development of transgenic papaya technology

Mendoza

Laurena

Botella

2008

Biotechnology Annual Review

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Abstract. Papaya with resistance to papaya ringspot virus (PRSV) is the first genetically modified tree and fruit crop and also the first transgenic crop developed by a public institution that has been commercialized. This chapter reviews the different transformation systems used for papaya and recent advances in the use of transgenic technology to introduce important quality and horticultural traits in papaya. These include the development of the following traits in papaya: resistance to PRSV, mites and Phytophthora, delayed ripening trait or long shelf life by inhibiting ethylene production or reducing loss of firmness, and tolerance or resistance to herbicide and aluminum toxicity. The use of papaya to produce vaccine against tuberculosis and cysticercosis, an infectious animal disease, has also been explored. Because of the economic importance of papaya, there are several collaborative and independent efforts to develop PRSV transgenic papaya technology in 14 countries. This chapter further reviews the strategies and constraints in the adoption of the technology and biosafety to the environment and food safety. Constraints to adoption include public perception, strict and expensive regulatory procedures and intellectual property issues.

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Section: Food Safetymentioning

confidence: 99%

Recent advances in the development of transgenic papaya technology

Mendoza

Laurena

Botella

2008

Biotechnology Annual Review

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“…The International Food Biotechnology Council (IFBC) and the ILSI Allergy and Immunology Institute sponsored a study (25) on a decision-tree approach for assessment of potential allergenicity of transgenic proteins in crop plants. This study includes a list of protein allergen sequences submitted to public databases.…”

Section: Ifbc/ilsimentioning

confidence: 99%

Allergen databases

Brusic

Millot

Petrovsky

et al. 2003

Allergy

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Allergies represent a significant medical and industrial problem. Molecular and clinical data on allergens are growing exponentially and in this article we have reviewed nine specialized allergen databases and identified data sources related to protein allergens contained in general purpose molecular databases. An analysis of allergens contained in public databases indicates a high level of redundancy of entries and a relatively low coverage of allergens by individual databases. From this analysis we identify current database needs for allergy research and, in particular, highlight the need for a centralized reference allergen database.

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“…A method for the assessment of the allergenic potential of proteins, using a decision tree that classifies the source of the protein, has been described (86). The decision components in this approach combine the measurements of in vivo and in vitro immunological responses and include a sequence comparison step.…”

Section: Prediction Of Allergenicitymentioning

confidence: 99%

Computational tools for the study of allergens

Brusic

Petrovsky

Gendel

et al. 2003

Allergy

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Allergy is a major cause of morbidity worldwide. The number of characterized allergens and related information is increasing rapidly creating demands for advanced information storage, retrieval and analysis. Bioinformatics provides useful tools for analysing allergens and these are complementary to traditional laboratory techniques for the study of allergens. Specific applications include structural analysis of allergens, identification of B‐ and T‐cell epitopes, assessment of allergenicity and cross‐reactivity, and genome analysis. In this paper, the most important bioinformatic tools and methods with relevance to the study of allergy have been reviewed.

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Assessment of the allergenic potential of foods derived from genetically engineered crop plants*

Cited by 382 publications

References 82 publications

Recent advances in the development of transgenic papaya technology

Recent advances in the development of transgenic papaya technology

Allergen databases

Computational tools for the study of allergens

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