2019
DOI: 10.1007/s13566-019-00398-8
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Assessment of the alpha/beta ratio of the optic pathway to adjust hypofractionated stereotactic radiosurgery regimens for perioptic lesions

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Cited by 10 publications
(5 citation statements)
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“…It has been shown that this assumption affects the range and biological effectiveness of protons in the patient and is therefore linked to a non-negligible amount of uncertainty. 40,41 Not taking into account variable RBE, possible variations in proton range 42 31 would have led to dosimetric differences of about 1% with minor impact on the modelling results.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It has been shown that this assumption affects the range and biological effectiveness of protons in the patient and is therefore linked to a non-negligible amount of uncertainty. 40,41 Not taking into account variable RBE, possible variations in proton range 42 31 would have led to dosimetric differences of about 1% with minor impact on the modelling results.…”
Section: Discussionmentioning
confidence: 99%
“…All patients included in the cohort received at least 45 Gy RBE (D max ) to one or more of the optic structures, calculated using a fixed RBE of 1.1 29 . Due to mixed fractionation regimes (1.8 -2.0 Gy RBE /fraction) applied to the patients however, all fraction doses have been converted to a biologically equivalent dose (BED) 30 of 2 Gy RBE per fraction with an -ratio of 1.07 Gy 31 which is in the range of other published values 4 and within the recommended range for clinical use 32 . Data processing and analysis was done with MATLAB® R2018b (Mathworks Inc, Natick, MA, USA).…”
Section: J O U R N a L P R E -P R O O Fmentioning
confidence: 99%
“…Nonetheless, there is strong evidence concerning dose limits and the risk of adverse events with hypofractionated regimens due to the extensive number of publications on a variety of skull base and perioptic tumors commonly treated in five fractions. Also, the panhypopituitarism, temporal lobe necrosis, and cranial nerve neuropathy are late adverse events described in the literature after standard PBRT, but since the α/β ratio of chordomas is similar to the α/β ratio of healthy brain structures at risk, the dose-dependent toxicity should not substantially differ in different fractionation regimens [36][37][38].…”
Section: Discussionmentioning
confidence: 99%
“…Biologically effective dose (BED) is routinely used to compare doses of different dose-fraction regimens, based on the widely accepted linear quadratic (LQ) model, although with its limitations for high doses still in debate. 24 HFSRS doses can be converted to single fraction equivalent doses (SFED), 25 to intuitively compare radiation effects to conventional physical doses of single fraction radiosurgery. Margin SFED of the seven HFSRS treatments was on average 11.5 Gy, applying an α/β ratio of 3.76 Gy.…”
Section: Patients and Meningiomasmentioning
confidence: 99%