Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus–Induced Infection in Rats

Awad, Mohammed; Yosri, Mohammed; Abdel‐Aziz, Marwa M.; Younis, Ahmed; Sidkey, Nagwa M.

doi:10.1007/s12011-020-02561-6

Cited by 17 publications

(9 citation statements)

References 66 publications

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“…The efficacy of some antibiotics, such as vancomycin, can be further improved by adding ε‐PLL thanks to synergetic effects between the drug and the homopolymer. [ 50 ]…”

Section: Coating Surfaces With ε‐Pllmentioning

confidence: 99%

The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials

Lebaudy,

Guilbaud-Chéreau,

Frisch

et al. 2023

Advanced NanoBiomed Research

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ε‐poly‐l‐lysine (ε‐PLL) is a natural polypeptide/polycation originating from bacteria. Thanks to its antifungal and antibacterial properties, it is the subject of extensive research in the food and medical industries. ε‐PLL is also used to develop biomaterials in a broad range of applications, such as drug delivery, wound healing, or antimicrobial coatings. Indeed, loading ε‐PLL inside nanoparticles, functionalizing implant surfaces with ε‐PLL, or developing hydrogels based on reactions between ε‐PLL and other polymers can improve the materials properties, leading to biocompatible, antibacterial, and antifungal systems. These characteristics are necessary not only for the development of biomaterials, for their integrity in a biological environment, but also for improving the performances of medical devices. Moreover, ε‐PLL can be used as an alternative to antibiotics as its mechanism of action reduces the bacterial resistance risk compared with antibiotics. Finally, “smart” systems using ε‐PLL may be developed, with controllable material degradation or drug delivery via pH or temperature variations. This review sought to gather the latest research on the development of antimicrobial biomaterials based on the ε‐PLL polypeptide.

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“…The efficacy of some antibiotics, such as vancomycin, can be further improved by adding ε‐PLL thanks to synergetic effects between the drug and the homopolymer. [ 50 ]…”

Section: Coating Surfaces With ε‐Pllmentioning

confidence: 99%

The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials

Lebaudy,

Guilbaud-Chéreau,

Frisch

et al. 2023

Advanced NanoBiomed Research

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“…AgNPs (45 ± 15 nm) biosynthesized using Dolomiaea costus extract were reported to kill E. coli , Acinetobacter baumannii , S. aureus and MRSA at a dose of 1 μg/mL [ 269 ]. AgNPs prepared using Agaricus bisporus basidiomycete mushroom extract as a reducing and capping agent with an average size of 27.45 nm increased the in vitro and in vivo antibacterial activity of VAN against MRSA; in combination with VAN, the AgNPs were found to be effective in the lungs of rats infected with MRSA [ 270 ]. AgNPs green-synthesized using cyanobacterium Phormidium sp.…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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“…Indeed, the incorporation of several bacteria-killing approaches in the framework of single coatings can significantly decrease the risk of resistant strain development or kill the previously developed resistant strains [198]. Moreover, the synergy in antimicrobial action is often observed [199], ensuring a high degree of antimicrobial activity, highly desired in specific medical applications (for example, implants surface protection) [200].…”

Section: Multidrug Approachmentioning

confidence: 99%

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

et al. 2021

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Bacterial environmental colonization and subsequent biofilm formation on surfaces represents a significant and alarming problem in various fields, ranging from contamination of medical devices up to safe food packaging. Therefore, the development of surfaces resistant to bacterial colonization is a challenging and actively solved task. In this field, the current promising direction is the design and creation of nanostructured smart surfaces with on-demand activated amicrobial protection. Various surface activation methods have been described recently. In this review article, we focused on the “physical” activation of nanostructured surfaces. In the first part of the review, we briefly describe the basic principles and common approaches of external stimulus application and surface activation, including the temperature-, light-, electric- or magnetic-field-based surface triggering, as well as mechanically induced surface antimicrobial protection. In the latter part, the recent achievements in the field of smart antimicrobial surfaces with physical activation are discussed, with special attention on multiresponsive or multifunctional physically activated coatings. In particular, we mainly discussed the multistimuli surface triggering, which ensures a better degree of surface properties control, as well as simultaneous utilization of several strategies for surface protection, based on a principally different mechanism of antimicrobial action. We also mentioned several recent trends, including the development of the to-detect and to-kill hybrid approach, which ensures the surface activation in a right place at a right time.

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Assessment of the Antibacterial Potential of Biosynthesized Silver Nanoparticles Combined with Vancomycin Against Methicillin-Resistant Staphylococcus aureus–Induced Infection in Rats

Cited by 17 publications

References 66 publications

The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials

The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials

Advances in Nanostructures for Antimicrobial Therapy

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

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