Assessment of the antidiabetic potential of Cassia grandis using an in vivo model

Lodha, Sandesh; Joshi, Shrikant V; Vyas, Bhavin; Upadhye, Mohini; Kirve, Megha S; Salunke, Shweta S; Kadu, Sheetal K; Rogye, Manasi V

doi:10.4103/0110-5558.72429

Cited by 21 publications

(13 citation statements)

References 14 publications

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“…Natural α-amylase and α-glycosidase inhibitors from food-grade plant sources offer an attractive therapeutic approach for the treatment of postprandial hyperglycemia by decreasing glucose release from starch and delaying carbohydrate absorption by inhibiting the activity of the carbohydrate hydrolyzing enzymes in the small intestine and may have potential for use in the treatment of diabetes mellitus and obesity. [ 19 20 ] On the basis of the prevalence, the delay or inhibition of carbohydrate digestion would contribute to optimize a postprandial blood glucose level. There are many natural resources with the α-glucosidase inhibitory activity and some of them are more specific for sucrose inhibition rather than maltase inhibition.…”

Section: Resultsmentioning

confidence: 99%

In-vitro α amylase and glycosidase inhibitory effect of ethanolic extract of antiasthmatic drug - Shirishadi

Kajaria

Ranjana

Tripathi

et al. 2013

J Adv Pharm Technol Res

113

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Asthma and diabetes have strong relationship; both are cause and effect of each other. Oxidative stress due to bronchial asthma may cause insulin resistance whereas lack of proper insulin can cause defective smooth muscle relaxant. There is no single medicine available that can manage both diseases, rather the mainstay treatment of bronchial asthma causes hyperglycemia. Keeping this problem in focus, in this study the hypoglycemic effect of an indigenous antiasthmatic Ayurvedic drug Shirishadi was evaluated. Pancreatic alpha amylase and glucosidase inhibitors offer an effective strategy to lower the level of post prandial hyperglycemia via control of starch breakdown. For evaluation of hypoglycemic activity of drug, in-vitro alpha amylase and alpha glucosidase enzyme inhibition was calculated. Ethanolic extract of compound showed 76.40% + 0.88% reduction in alpha amylase activity and 63.85% + 0.36% in alpha glucosidase activity with IC50 0.68 mg/ml and 2.89 mg/ml, respectively. This study suggests that the ethanolic extract of Shirishadi polyherbal compound effectively acts as alpha amylase and glucosidase inhibitor leading to a reduction in starch hydrolysis and hence acts as antiasthmatic as well as hypoglycemic drug.

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Section: Resultsmentioning

confidence: 99%

In-vitro α amylase and glycosidase inhibitory effect of ethanolic extract of antiasthmatic drug - Shirishadi

Kajaria

Ranjana

Tripathi

et al. 2013

J Adv Pharm Technol Res

113

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“…The aqueous and ethanolic extracts of Cassia grandis (Leguminosae) in diabetic rats at the dose level of 150 mg/ kg, p.o. for ten days treatment, significantly decreased the blood glucose, TC, and TG level proving its anti-diabetic potential [26] .…”

Section: Cassia Grandismentioning

confidence: 88%

Diabetes mellitus: An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity

Patel

Kumar

Laloo

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

282

141

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Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge number of population in the world. It is mainly characterized by chronic hyperglycemia, resulting from defects in insulin secretion or insulin action. It is predicated that the number of diabetes person in the world could reach upto 366 million by the year 2030. Even though the cases of diabetes are increasing day by day, except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far. Thus, the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic disorder. The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used nowadays. Alloxan and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular drug. This review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat model. From the available data in the literature, it was found that plant having antidiabetic activity is mainly due to the presence of the secondary metabolite. Thus, the information provided in this review will help the researchers for the development of an alternative methods rather than insulin and oral hypoglycemic agents for the treatment of diabetes mellitus, which will minimize the complication associated with the diabetes and related disorder.

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“…The aqueous and ethanolic extracts of Cassia grandis (150 mg/kg, p.o. for 10 days treatment) were evaluated for antidiabetic activity by a GTT in normal rats and alloxan-induced diabetic rats [908]. The two extracts showed antidiabetic potential, decreasing the blood glucose, TC, and TG levels.…”

Section: Medicinal Plants With Antidiabetic Potentialmentioning

confidence: 99%

Antidiabetic Potential of Medicinal Plants and Their Active Components

et al. 2019

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Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.

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Assessment of the antidiabetic potential of Cassia grandis using an in vivo model

Cited by 21 publications

References 14 publications

In-vitro α amylase and glycosidase inhibitory effect of ethanolic extract of antiasthmatic drug - Shirishadi

In-vitro α amylase and glycosidase inhibitory effect of ethanolic extract of antiasthmatic drug - Shirishadi

Diabetes mellitus: An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity

Antidiabetic Potential of Medicinal Plants and Their Active Components

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