Assessment of the antioxidant and anticancer potential of different isolated strains of cyanobacteria and microalgae from soil and agriculture drain water

Senousy, Hoda H.; Ellatif, Sawsan Abd; Ali, Shafaqat

doi:10.1007/s11356-020-08332-z

Cited by 53 publications

(27 citation statements)

References 41 publications

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“…Toxic concentrations of B occur in soils that are irrigated with water contaminated with B or an excessive use of B-rich fertilizer, sewage sludge, as well as natural deposits discovered throughout the globe in arid and semi-arid areas [2]. Boron stress induces certain biochemical and morphological failures, such as reduced shoot and root development [3,4]; photosynthesis inhibition; reduced stomatal conductance [5]; the generation of reactive oxygen species (ROS) causing oxidative stress to lipids, proteins, and nucleic acids [6]; reduced root proton extrusion [7], reduced root cell division [8]; lignin and suberin accumulation in roots [9]; increased permeability of the membrane; lipid peroxidation; and altered antioxidant enzyme activities [10]. Scientists have been interested in developing potential strategies to enhance the seeds germination and the plants growth to achieve higher crop production [11,12].…”

Section: Introductionmentioning

confidence: 99%

Salicylic Acid Stimulates Antioxidant Defense and Osmolyte Metabolism to Alleviate Oxidative Stress in Watermelons under Excess Boron

Moustafa-Farag

Mohamed

Mahmoud

et al. 2020

Plants

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Boron (B) is a microelement required in vascular plants at a high concentration that produces excess boron and toxicity in many crops. B stress occurs widely and limits plant growth and crop productivity worldwide. Salicylic acid (SA) is an essential hormone in plants and is a phenolic compound. The goal of this work is to explore the role of SA in the alleviation of excess B (10 mg L−1) in watermelon plants at a morphological and biochemical level. Excess boron altered the nutrient concentrations and caused a significant reduction in morphological criteria; chlorophyll a, b, and carotenoids; net photosynthetic rate; and the stomatal conductance and transpiration rate of watermelon seedlings, while intercellular carbon dioxide (CO2) was significantly increased compared to the control plants (0.5 mg L−1 B). Furthermore, excess boron accelerated the generation of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2) and induced cellular oxidative injury. The application of exogenous SA significantly increased chlorophyll and carotenoid contents in plants exposed to excess B (10 mg L−1), in line with the role of SA in alleviating chlorosis caused by B stress. Exogenously applied SA promoted photosynthesis and, consequently, biomass production in watermelon seedlings treated with a high level of B (10 mg L−1) by reducing B accumulation, lipid peroxidation, and the generation of H2O2, while significantly increasing levels of the most reactive ROS, OH−. SA also activated antioxidant enzymes, such as superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX) and protected the seedlings from an ROS induced cellular burst. In conclusion, SA can be used to alleviate the adverse effects of excess boron.

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Section: Introductionmentioning

confidence: 99%

Salicylic Acid Stimulates Antioxidant Defense and Osmolyte Metabolism to Alleviate Oxidative Stress in Watermelons under Excess Boron

Moustafa-Farag

Mohamed

Mahmoud

et al. 2020

Plants

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“…The harmful effects of drought stress on plants are usually associated with several events at cellular, biochemical, physiological and molecular levels that may enable the plants to adapt or tolerate such conditions [4][5][6]. These responses include the rapid generation of reactive oxygen species (ROS) [7], development of an array of complex antioxidant (nonenzymatic and enzymatic) systems [8], regulation of the expression of tolerance related genes [9] and alternation of nutrient uptake [10].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Agronomic Traits, Nutrient Uptake, Osmolytes and Antioxidants of Maize as Influenced by Exogenous Potassium Silicate under Deficit Irrigation and Semiarid Conditions

et al. 2020

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Understanding the link between the protective role of potassium silicate (K2SiO3) against water shortage and the eventual grain yield of maize plants is still limited under semiarid conditions. Therefore, in this study, we provide insights into the underlying metabolic responses, mineral nutrients uptake and some nonenzymatic and enzymatic antioxidants that may differ in maize plants as influenced by the foliar application of K2SiO3 (0, 1 and 2 mM) under three drip irrigation regimes (100, 75 and 50% of water requirements). Our results indicated that, generally, plants were affected by both moderate and severe deficit irrigation levels. Deficit irrigation decreased shoot dry weight, root dry weight, leaf area index (LAI), relative water content (RWC), N, P, K, Ca, Fe, Zn, carotenoids, grain yield and its parameters, while root/shoot ratio, malondialdehyde (MDA), proline, soluble sugars, ascorbic acid, soluble phenols, peroxidase (POD), catalase (CAT), polyphenol oxidase (PPO), and ascorbate peroxidase (APX) were improved. The foliar applications of K2SiO3 relatively alleviated water stress-induced damage. In this respect, the treatment of 2 mM K2SiO3 was more effective than others and could be recommended to mitigate the effect of deficit irrigation on maize plants. Moreover, correlation analysis revealed a close link between yield and the most studied traits.

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“…On the other hand, Chlorella sorokiniana HSSASE17 and Dolichospermum flos-aquae HSSASE2 showed cytotoxicity with IC 50 values of 498.9 ± 0.3 and 337 ± 0.9 lg/ml. These results represented that algal extracts may show cytotoxic effect on healthy cells under very high concentrations [22].…”

Section: Assessment Of Cytotoxicity Of Microalgal Oil Extractsmentioning

confidence: 81%

Comparison of the anticancer effect of microalgal oils and microalgal oil-loaded electrosprayed nanoparticles against PC-3, SHSY-5Y and AGS cell lines

İnan

Çakır-Koç

Özçimen

2021

Artificial Cells, Nanomedicine, and Biotechnology

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Many of the bioactive substances used in pharmaceutical industry are easily affected by temperature, light and oxygen, and are easily degraded during storage and processing, and exhibit poor adsorption properties during digestion, which limits their direct use. Microalgae are rich in oils which have antimicrobial properties and antioxidants that attract attention in both food and pharmaceutical sectors in recent years. Studies to encapsulate bioactive compound-rich microalgae oils with nanotechnological approaches to improve the physical and chemical stability are relatively new, and it is promising to apply these approaches for pharmaceutical purposes. In this study, cytotoxic effects of oil extracts of Botryococcus braunii and Microcystis aeruginosa and their oil-loaded nanoparticles on L929 cell line, PC-3 prostate cell line, SHSY-5Y neuroblastoma cell line and AGS gastric adenocarcinoma cell line were investigated. The obtained extracts were found to have no cytotoxic effect on L929 cells. However, they showed cytotoxic effect on cancer cells. As for the nanoparticles; a gradual release was determined and the stability of the nanoparticle structure was shown. In the light of obtained findings, it was considered that nanoparticles produced with oil extracts of microalgae which have bioactive substances, have potential to be evaluated especially in pharmaceutical and cosmetic fields.

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Assessment of the antioxidant and anticancer potential of different isolated strains of cyanobacteria and microalgae from soil and agriculture drain water

Cited by 53 publications

References 41 publications

Salicylic Acid Stimulates Antioxidant Defense and Osmolyte Metabolism to Alleviate Oxidative Stress in Watermelons under Excess Boron

Salicylic Acid Stimulates Antioxidant Defense and Osmolyte Metabolism to Alleviate Oxidative Stress in Watermelons under Excess Boron

Regulation of Agronomic Traits, Nutrient Uptake, Osmolytes and Antioxidants of Maize as Influenced by Exogenous Potassium Silicate under Deficit Irrigation and Semiarid Conditions

Comparison of the anticancer effect of microalgal oils and microalgal oil-loaded electrosprayed nanoparticles against PC-3, SHSY-5Y and AGS cell lines

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