Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males

Abstract

Background Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignant neoplasms of the upper respiratory tract. Studies have confirmed that an unstable chromosome constitution promotes the progress of laryngeal tumorigenesis, and ACYP2 has been confirmed as a telomere length‐related gene. However, to date, the association between ACYP2 polymorphisms and LSCC susceptibility has not been investigated. Methods We performed this study to explore the effect of 11 single‐nucleotide polymorphisms (SNPs) in ACYP2 on LSCC susceptibility in Chinese Han males. Unconditional logistic regression analysis adjusted for age was used to calculate the odds ratios and 95% confidence intervals. Results Based on allele and genotype models, our results showed that rs1682111 variant was significantly associated with a decreased LSCC susceptibility ( p < 0.05). On the contrary, polymorphisms of rs10439478, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 were significantly associated with an increased LSCC risk ( p < 0.05). The results of haplotype analysis indicated that haplotypes “TTCTCG” and “TTCTAA” in block 1 and “TG” in block 2 showed a risk factor for the development of LCSS ( p = 0.009, p < 0.001, and p = 0.001, respectively). The results of Genotype‐Tissue Expression analysis indicate that these significant SNPs were known to be associated with ACYP2 expression. Conclusion Our data demonstrated that ACYP2 polymorphisms may exert effects on LSCC susceptibility in Chinese Han males.

Analysis of rs1048943 in the CYP1A1 gene in laryngeal cancer - a case control study

“…Laryngeal cancer is one of the most predominant cancers of the upper respiratory tract 18 . It is rare in individuals under 60 years of age with three quarters of all diagnoses occurring in people over 60 19 .…”

Mode of action of carboplatin via activating p53/miR‐145 axis in head and neck cancers

“…3,4 Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors of the upper respiratory tract and is the second most common type of the respiratory cancers in the world. [5][6][7] Because the larynx has important functions, such as breathing and swallowing, its treatment significantly affects quality of life. 8 In addition, hypopharyngeal squamous cell carcinoma (HSCC) accounts for 3% to 5% of all head and neck cancers.…”

“…Lifestyle, various genetic risk factors, smoking, alcohol consumption, poor oral hygiene, and human papillomavirus infection are known as major risk factors for HNSCC 3–4 . Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors of the upper respiratory tract and is the second most common type of the respiratory cancers in the world 5–7 . Because the larynx has important functions, such as breathing and swallowing, its treatment significantly affects quality of life 8 .…”