2024
DOI: 10.1111/jop.13541
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Assessment of the association of myofibroblasts and structural components of the extracellular matrix with histopathological parameters of actinic cheilitis and lower lip squamous cell carcinoma

Farah Essgui Orellana Martinez,
Thâmara Manoela Marinho Bezerra,
Ana Paula Negreiros Nunes Alves
et al.

Abstract: BackgroundTo evaluate the presence of myofibroblasts (MFs) in the development of lip carcinogenesis, through the correlation of clinical, histomorphometric and immunohistochemical parameters, in actinic cheilitis (ACs) and lower lip squamous cell carcinomas (LLSCCs).MethodsSamples of ACs, LLSCCs, and control group (CG) were prepared by tissue microarray (TMA) for immunohistochemical TGF‐β, α‐SMA, and Ki‐67 and histochemical hematoxylin and eosin, picrosirius red, and verhoeff van gieson reactions. Clinical and… Show more

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