Assessment of the association of exposure to polycyclic aromatic hydrocarbons, oxidative stress, and inflammation: A cross-sectional study in Augsburg, Germany

Wu, Xiao; Cao, Xin; Lintelmann, Jutta; Peters, Annette; Köenig, Wolfgang; Zimmermann, Ralf; Schneider, Alexandra; Wolf, Kathrin

doi:10.1016/j.ijheh.2022.113993

Cited by 14 publications

(7 citation statements)

References 91 publications

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“…8 Macromolecular substances such as ribonucleic acid (RNA), deoxyribonucleic acid (DNA), lipids, and proteins in living organisms are attacked and modified by ROS, and the activity of ROS serves as a crucial initiator of both acute and chronic health issues. 4 Oxidative stress is closely related to pathologic physiology. The potential stable derivatives of oxidants (OSBs) are indicators for the diagnosis and prevention of diseases.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Polycyclic aromatic hydrocarbons (PAHs), a class of ubiquitous and hazardous chemical substances, are derived from the incomplete combustion of chemical fuels and organic compounds, such as cigarette smoke, domestic combustion, traffic emissions, and industrial production . The United States Environmental Protection Agency (USEPA) has categorized PAHs as priority pollutants because of their widespread distribution and negative effects on the balance of the ecological environment and human health. , Lipophilic PAHs can be absorbed into the body simultaneously through the dermal, respiratory, or ingestion routes . The PAHs are converted to monohydroxylated metabolites (OH-PAHs) after entering human bodies and are excreted with urine as glucuronide and sulfate conjugates .…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Lipophilic PAHs can be absorbed into the body simultaneously through the dermal, respiratory, or ingestion routes. 4 The PAHs are converted to monohydroxylated metabolites (OH-PAHs) after entering human bodies and are excreted with urine as glucuronide and sulfate conjugates. 5 Therefore, urinary OH-PAHs have been broadly adopted as useful biomarkers for monitoring PAH exposure levels and assessing PAH exposure health risks.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Cellular studies suggest that PAH metabolites might produce reactive oxygen species (ROS), such as peroxides, superoxides, and hydroxyl radicals, by establishing redox cycles . Macromolecular substances such as ribonucleic acid (RNA), deoxyribonucleic acid (DNA), lipids, and proteins in living organisms are attacked and modified by ROS, and the activity of ROS serves as a crucial initiator of both acute and chronic health issues . Oxidative stress is closely related to pathologic physiology.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Metabolites of Polycyclic Aromatic Hydrocarbons of Rural Population in Northwestern China: Oxidative Stress and Health Risk Assessment

Hua,

Gao,

Guo

et al. 2024

Environ. Sci. Technol.

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Polycyclic aromatic hydrocarbon (PAH) exposure is suspected to be linked to oxidative damage. Herein, ten PAH human exposure biomarkers [hydroxylated PAH metabolites (OH-PAHs)] and five oxidative stress biomarkers (OSBs) were detected in urine samples collected from participants living in a rural area (n = 181) in Northwestern China. The median molar concentration of ΣOH-PAHs in urine was 47.0 pmol mL −1 . The 2hydroxynaphthalene (2-OHNap; median: 2.21 ng mL −1 ) was the dominant OH-PAH. The risk assessment of PAH exposure found that hazard index (HI) values were <1, indicating that the PAH exposure of rural people in Jingyuan would not generate significant cumulative risks. Smokers (median: 0.033) obtained higher HI values than nonsmokers (median: 0.015, p < 0.01), suggesting that smokers face a higher health risk from PAH exposure than nonsmokers. Pearson correlation and multivariate linear regression analysis revealed that ΣOH-PAH concentrations were significant factors in increasing the oxidative damage to deoxyribonucleic acid (DNA) (8-hydroxy-2′-deoxyguanosine, 8-OHdG), ribonucleic acid (RNA) (8-oxo-7,8-dihydroguanine, 8-oxoGua), and protein (o, o′-dityrosine, diY) (p < 0.05). Among all PAH metabolites, only 1-hydroxypyrene (1-OHPyr) could positively affect the expression of all five OSBs (p < 0.05), suggesting that urinary 1-OHPyr might be a reliable biomarker for PAH exposure and a useful indicator for assessing the impacts of PAH exposure on oxidative stress. This study is focused on the relation between PAH exposure and oxidative damage and lays a foundation for the study of the health effect mechanism of PAHs.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary Metabolites of Polycyclic Aromatic Hydrocarbons of Rural Population in Northwestern China: Oxidative Stress and Health Risk Assessment

Hua,

Gao,

Guo

et al. 2024

Environ. Sci. Technol.

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“…Oxidative stress and inflammation are common denominators of particulate matter (PM) air pollution exposures (92), including PM containing polycyclic aromatic hydrocarbons (PAHs) at low exposure settings. Occupational exposures are equally important for both systemic and neural inflammation and neurodegeneration (93,94).…”

Section: Introductionmentioning

confidence: 99%

Sleep matters: Neurodegeneration spectrum heterogeneity, combustion and friction ultrafine particles, industrial nanoparticle pollution, and sleep disorders—Denial is not an option

Calderón‐Garcidueñas

Torres‐Jardón²,

Greenough³

et al. 2023

Front. Neurol.

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Sustained exposures to ubiquitous outdoor/indoor fine particulate matter (PM2.5), including combustion and friction ultrafine PM (UFPM) and industrial nanoparticles (NPs) starting in utero, are linked to early pediatric and young adulthood aberrant neural protein accumulation, including hyperphosphorylated tau (p-tau), beta-amyloid (Aβ1 − 42), α-synuclein (α syn) and TAR DNA-binding protein 43 (TDP-43), hallmarks of Alzheimer's (AD), Parkinson's disease (PD), frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS). UFPM from anthropogenic and natural sources and NPs enter the brain through the nasal/olfactory pathway, lung, gastrointestinal (GI) tract, skin, and placental barriers. On a global scale, the most important sources of outdoor UFPM are motor traffic emissions. This study focuses on the neuropathology heterogeneity and overlap of AD, PD, FTLD, and ALS in older adults, their similarities with the neuropathology of young, highly exposed urbanites, and their strong link with sleep disorders. Critical information includes how this UFPM and NPs cross all biological barriers, interact with brain soluble proteins and key organelles, and result in the oxidative, endoplasmic reticulum, and mitochondrial stress, neuroinflammation, DNA damage, protein aggregation and misfolding, and faulty complex protein quality control. The brain toxicity of UFPM and NPs makes them powerful candidates for early development and progression of fatal common neurodegenerative diseases, all having sleep disturbances. A detailed residential history, proximity to high-traffic roads, occupational histories, exposures to high-emission sources (i.e., factories, burning pits, forest fires, and airports), indoor PM sources (tobacco, wood burning in winter, cooking fumes, and microplastics in house dust), and consumption of industrial NPs, along with neurocognitive and neuropsychiatric histories, are critical. Environmental pollution is a ubiquitous, early, and cumulative risk factor for neurodegeneration and sleep disorders. Prevention of deadly neurological diseases associated with air pollution should be a public health priority.

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Antioxidant Activity and Mechanism of Cinnamon

Oliveira

Qiao

2023

Food Bioactive Ingredients

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Assessment of the association of exposure to polycyclic aromatic hydrocarbons, oxidative stress, and inflammation: A cross-sectional study in Augsburg, Germany

Cited by 14 publications

References 91 publications

Urinary Metabolites of Polycyclic Aromatic Hydrocarbons of Rural Population in Northwestern China: Oxidative Stress and Health Risk Assessment

Urinary Metabolites of Polycyclic Aromatic Hydrocarbons of Rural Population in Northwestern China: Oxidative Stress and Health Risk Assessment

Sleep matters: Neurodegeneration spectrum heterogeneity, combustion and friction ultrafine particles, industrial nanoparticle pollution, and sleep disorders—Denial is not an option

Antioxidant Activity and Mechanism of Cinnamon

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