Assessment of the autonomic nervous system is an appropriate biological marker for the well-being in erectile dysfunction*

Doğru, Tolga; Koçak, Orhan Murat; Erberk-Özen, Nurper; Başar, Murat

doi:10.1111/j.1745-7262.2008.00383.x

Cited by 10 publications

(14 citation statements)

References 31 publications

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“…More broadly, findings may point toward the underlying role of HRV in the physiology of erectile hemodynamics. Results of the present investigation were in line with prior studies showing associations between healthy sympathovagal balance (i.e., relative enhancement in parasympathetic activity and diminution in sympathetic activity) and enhanced EF [24–27,43]. Moreover, these findings supplement the growing body of literature exploring relationships between HRV and sexual health more broadly.…”

Section: Discussionsupporting

confidence: 91%

Concurrent Relations among Cigarette Smoking Status, Resting Heart Rate Variability, and Erectile Response

Harte¹

2014

The Journal of Sexual Medicine

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Introduction Heart rate variability (HRV) is a marker of sympathovagal balance; it has been implicated in erectile function and is also altered by tobacco use. Furthermore, smoking and erectile health are strongly related, given that smokers are at increased risk for erectile dysfunction. Few studies have explored the interrelationships between smoking, HRV, and erectile function concurrently. Aim The aim of this study was to examine potential mechanisms underlying tobacco's effects on penile hemodynamics by exploring the mediating role of HRV. Methods The sample comprised 119 men (smokers = 64; nonsmokers = 55) (mean age 28.90 years; standard deviation (SD) 11.68; range 18–58) selected from the control conditions of three previously published experiments. Participants were free from a history of cardiovascular disease, myocardial infarct, and/or cardiac/cardiovascular medication use. During a laboratory visit, self-report, anthropometric, cardiovascular, and electrocardiographic data were assessed, as well as sexual arousal responses elicited from viewing an erotic film. Main Outcome Measures Objective sexual arousal indices (circumferential change via penile plethysmography), self-reported erectile function (per the erectile function domain score of the International Index of Erectile Function [IIEF-EF]), and time- (SD of beat-to-beat intervals) and frequency-domain parameters of HRV (ratio of low-frequency [LF] power to high-frequency [HF] power [LF/HF ratio]) were assessed. Results Being a current long-term cigarette smoker was associated with dysregulated sympathovagal balance (higher LF/HF ratios, indicative of sympathetic nervous system dominance), which in turn showed inverse relations with magnitude of erectile tumescence. HRV did not mediate relations between tobacco use and either IIEF-EF scores or resting penile circumference. Conclusions Findings suggest that dysfunctional cardiac autonomic tone may be an underlying mechanism by which tobacco exerts its deleterious effects on erectile health. Further research is necessary to determine whether this relationship is mechanistic in nature, or whether it is better explained by other health factors.

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Section: Discussionsupporting

confidence: 91%

Concurrent Relations among Cigarette Smoking Status, Resting Heart Rate Variability, and Erectile Response

Harte¹

2014

The Journal of Sexual Medicine

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“…When sympatho-vagal balance expressed as LF/HF ratio was compared between the two groups under three different body positions (supine, seated, and standing position), LF/HF ratio of the disease subject was increased dramatically. Dogru et al [14] reported that ED group had significantly higher value of sympathetic activity indicator (LF/HF ratio) than the control group, but there was no difference between the two groups in terms of parasympathetic activity indicator (HF). These results support the idea that ED patients have excessive sympathetic activity and out study had similar results.…”

Section: Discussionmentioning

confidence: 99%

“…The digitized electrocardiography signals were analyzed by online database and stored on a hard disk for offline verification simultaneously. Two main analyses are performed for HRV: time domain and frequency domain analysis [14]. To compare the time domain indexes, we used mean heart rate (HR) in bpm, the standard deviation of all normal RR intervals (SDNN), and the square root of the mean differences between successive RR intervals (RMSSD).…”

Section: Methodsmentioning

confidence: 99%

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Heart Rate Variability in Men with Erectile dysfunction

et al. 2011

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PurposeThe objective of this study is to investigate alteration of autonomic nervous system (ANS) activity in patients suffering from erectile dysfunction (ED) by comparing parameters of heart rate variability (HRV) between men with ED and healthy subjects.MethodsA retrospective review was performed on 40 ED patients (mean age, 46.0±8.49 years) without any disease and 180 healthy control people (mean age, 44.4±7.83 years) without ED in our institution from June 2008 to July 2010. And electrocardiographic signals were obtained to measure HRV parameters for both patients and controls in a resting state.ResultsFor the time domain analysis, square root of the mean differences between successive RR intervals (RMSSD) representing parasympathetic activity was lower in patients than controls although P-value was not statistically significant (P=0.060). For the frequency domain analysis, high frequency (HF) representing parasympathetic activity was lower in patients than controls (P=0.232) and low frequency (LF) representing mainly sympathetic activity was higher in patients than controls (P=0.416). Lastly, LF/HF ratio reflecting sympathetic/parasympathetic activity ratio was statistically higher in patients than controls (P=0.027).ConclusionsPatients with ED exhibited different HRV parameters compared with normal controls. This suggests that the patients with ED may have some kind of imbalance in the ANS and it may be possible that general imbalance of the ANS is one of the causes of ED. Thus, HRV analysis may give valuable diagnostic information and serve as a rapid screening tool to evaluate altered ANS activity in patients with ED.

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“…Low frequency power ([LF] 0.04–0.15 Hz) has less clear associations with health [1,3] and sexual function [10,42,43]. Hence, we examine, but do not hypothesize on any association of LF with sexual behaviors or lifetime number of PVI partners.…”

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confidence: 99%

Greater Resting Heart Rate Variability is Associated with Orgasms Through Penile–Vaginal Intercourse, but Not with Orgasms from Other Sources

Costa

Brody

2012

The Journal of Sexual Medicine

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Introduction Resting heart rate variability (HRV), a marker of parasympathetic activity, is a predictor of health and longevity. Better erectile function is associated with greater resting HRV (assessed by high frequency power [HF]), and in both sexes, penile–vaginal intercourse (PVI) is the only sexual behavior consistently associated with indices of better physical and mental health, including greater resting HRV (assessed by standard deviation [SD] of heart rate [HR]). Aims To examine the hypotheses that greater frequency of orgasms attained through PVI (for women, without additional simultaneous clitoral stimulation; vaginal orgasm) are associated with greater resting HRV. A differential hypothesis is that HRV measures will be unrelated to orgasmic frequency from noncoital sexual activities. Methods Coitally experienced men and women (N = 143) had their heart rate measured for 5 minutes and reported the frequency of various sexual behaviors and corresponding orgasms in a recent representative month. Main Outcome Measures Partial correlations and analyses of covariance controlling for social desirability responding were used to examine the associations of sexual activities with time and frequency domains of HRV. Results For men, greater resting SD of HR was associated with greater PVI orgasm frequency. For women, greater resting SD of HR was associated with any vaginal orgasm. These findings remained after controlling for cohabitation. Sexual activities were unrelated to HF. Lifetime number of PVI partners was unrelated to SD of HR and HF. Conclusions Findings are discussed in the context of orgasms through PVI enhancing HRV, and greater parasympathetic tone favoring the capacity to engage in PVI, and in the case of women, to reach vaginal orgasm. The possibility of healthier people having greater resting HRV and more frequent orgasms through specifically PVI is also considered.

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Assessment of the autonomic nervous system is an appropriate biological marker for the well-being in erectile dysfunction*

Abstract: Quantitative assessment of the ANS by heart rate variability analysis might be a suitable marker for well-being of patients with ED.

Cited by 10 publications

References 31 publications

Concurrent Relations among Cigarette Smoking Status, Resting Heart Rate Variability, and Erectile Response

Concurrent Relations among Cigarette Smoking Status, Resting Heart Rate Variability, and Erectile Response

Heart Rate Variability in Men with Erectile dysfunction

Greater Resting Heart Rate Variability is Associated with Orgasms Through Penile–Vaginal Intercourse, but Not with Orgasms from Other Sources

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