Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2–7 months of age

Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine Administered According to 4 Different Primary Immunization Schedules in Infants

“…However, a previous study demonstrated that pneumococcal antibody responses after PCV7 vaccination were unaffected by either concurrent or sequential administration of DTaP-IPV-Hib and hepatitis B vaccines. 30 Third, our primary measure was IgG levels, and to corroborate our findings, functional assays were performed in a subset of samples and serotypes. Small discrepancies between the outcomes of the 3 assays might be explained by different subclasses of antibodies detected in these assays.…”

Simultaneous vaccination with Prevenar and multicomponent vaccines for children: Interference or no interference?

“…[18][19][20][21] Because the combination of Prevenar and Infanrix hexa is widely used within Europe, good information about the effects of simultaneous vaccination should be available, and predefined cut-off levels for the immune response to the different vaccine components should be maintained. We think that it is time to shed more light on the possible interference due to simultaneous vaccination with Prevenar and pentavalent and hexavalent combination vaccines, and that registration authorities should take the lead in achieving this.…”

La vacuna neumocócica conjugada heptavalente (Prevenar™): Diferencias en su efectividad en distintas poblaciones

“…La administración de esta vacuna junto con otras del calendario infantil no conlleva aumentos relevantes en la frecuencia de las reacciones adversas respecto a las que pueden atribuirse a cada vacuna por separado [49][50][51][52][53] .…”

“…Los ensayos que probaron pautas de 3 ó 4 dosis lograron respuestas inmunes por encima de 0,35 g/ml frente a todos los serotipos vacunales entre el 82% y el 100% de los niños vacunados [49][50][51][52] . Cuando la VNC7v se administra junto con otras del calendario infantil, los títulos de anticuerpos que se alcanzan frente a algunos antí-genos son ligeramente inferiores que cuando se administra aisladamente, pero esta diferencia parece no tener relevancia clíni-ca [49][50][51]53 . La VNC7v ha demostrado ser capaz de inducir la producción de anticuerpos incluso en niños con infecciones recurren-tes que no respondían a la vacuna polisacárida 56 .…”