Assessment of the conjunctival microcirculation in adult patients with cyanotic congenital heart disease compared to healthy controls

Brennan, Paul; Jing, Min; McNeil, Andrew; Awuah, Agnes; Mailey, Jonathan; Kelly, Bronagh; Finlay, Dewar; Blighe, Kevin; McLaughlin, James; Nesbit, M. Andrew; Trucco, Emanuele; Lockhart, Christopher; Moore, Tara; Spence, Mark S.

doi:10.1016/j.mvr.2021.104167

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…Conjunctival microvascular imaging was performed using our previously described non-invasive imaging tool (iPhone 6s with slit lamp biomicroscope) and semi-automated software; developed by the VAMPIRE centre (Dundee) and NIBEC (Ulster University) for quantifying vessel haemodynamic properties (vessel diameter (D), axial velocity (Va), cross-sectional velocity (Vs), Q, and WSR) 30 , 37 , 38 . The process is summarised as a flow diagram in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Estimation of blood vessel parameters has been previously described 30 , 37 – 39 . Video sequences with minimal motion artefact were selected.…”

Section: Methodsmentioning

confidence: 99%

“…Blood flow was calculated from the product of the cross-sectional velocity (Vs) and diameter (D), using the formula, (Vs.πD 2 )/4. Wall shear rate was calculated by the formula 8Vs/D 30 , 37 , 38 .…”

Section: Methodsmentioning

confidence: 99%

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A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers

Awuah

Moore

Nesbit

et al. 2022

Sci Rep

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Microvascular haemodynamic alterations are associated with coronary artery disease (CAD). The conjunctival microcirculation can easily be assessed non-invasively. However, the microcirculation of the conjunctiva has not been previously explored in clinical algorithms aimed at identifying patients with CAD. This case–control study involved 66 patients with post-myocardial infarction and 66 gender-matched healthy controls. Haemodynamic properties of the conjunctival microcirculation were assessed with a validated iPhone and slit lamp-based imaging tool. Haemodynamic properties were extracted with semi-automated software and compared between groups. Biomarkers implicated in the development of CAD were assessed in combination with conjunctival microcirculatory parameters. The conjunctival blood vessel parameters and biomarkers were used to derive an algorithm to aid in the screening of patients for CAD. Conjunctival blood velocity measured in combination with the blood biomarkers (N-terminal pro-brain natriuretic peptide and adiponectin) had an area under receiver operator characteristic curve (AUROC) of 0.967, sensitivity 93.0%, specificity 91.5% for CAD. This study demonstrated that the novel algorithm which included a combination of conjunctival blood vessel haemodynamic properties, and blood-based biomarkers could be used as a potential screening tool for CAD and should be validated for potential utility in asymptomatic individuals.

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Section: Methodsmentioning

confidence: 99%

“…Estimation of blood vessel parameters has been previously described 30 , 37 – 39 . Video sequences with minimal motion artefact were selected.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers

Awuah

Moore

Nesbit

et al. 2022

Sci Rep

Self Cite

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show abstract

“…Conjunctival microvascular imaging was performed using our previously described noninvasive imaging tool (iPhone 6s with slit lamp biomicroscope) and semi-automated software; developed by the VAMPIRE centre (Dundee) and NIBEC (Ulster University) for quantifying vessel haemodynamic properties (vessel diameter (D), axial velocity (Va), cross-sectional velocity (Vs), Q, and WSR) 30,37,38 . The process is summarised as a flow diagram in Figure 1.…”

Section: Conjunctival Vessel Imagingmentioning

confidence: 99%

“…Blood flow within the conjunctival vasculature can be directly visualised and hence assessment of microcirculatory parameters (e.g. velocity (V), flow (Q), wall shear rate (WSR)) can also be measured non-invasively 29,30,31 . The study by 31 assessed groups of subjects with and without hypertension, diabetes mellitus, dyslipidaemia, reduced left ventricular ejection fraction (<50%), as well as smokers vs. non-smokers.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Indices of Conjunctival Microvascular Function in Patients With and Without Obstructive Coronary Artery Disease

Mailey

Moore

Brennan

et al. 2023

Cardiovascular Revascularization Medicine

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Preoperative serum cortisone levels are associated with cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: new evidence from human populations and mice

Ma,

Liu,

Cun

et al. 2023

World J Pediatr

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Background Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Children with TOF would be confronted with neurological impairment across their lifetime. Our study aimed to identify the risk factors for cerebral morphology changes and cognition in postoperative preschool-aged children with TOF. Methods We used mass spectrometry (MS) technology to assess the levels of serum metabolites, Wechsler preschool and primary scale of intelligence-Fourth edition (WPPSI-IV) index scores to evaluate neurodevelopmental levels and multimodal magnetic resonance imaging (MRI) to detect cortical morphological changes. Results Multiple linear regression showed that preoperative levels of serum cortisone were positively correlated with the gyrification index of the left inferior parietal gyrus in children with TOF and negatively related to their lower visual spaces index and nonverbal index. Meanwhile, preoperative SpO2 was negatively correlated with levels of serum cortisone after adjusting for all covariates. Furthermore, after intervening levels of cortisone in chronic hypoxic model mice, total brain volumes were reduced at both postnatal (P) 11.5 and P30 days. Conclusions Our results suggest that preoperative serum cortisone levels could be used as a biomarker of neurodevelopmental impairment in children with TOF. Our study findings emphasized that preoperative levels of cortisone could influence cerebral development and cognition abilities in children with TOF.

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Assessment of the conjunctival microcirculation in adult patients with cyanotic congenital heart disease compared to healthy controls

Cited by 8 publications

References 45 publications

A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers

A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers

Assessment of Indices of Conjunctival Microvascular Function in Patients With and Without Obstructive Coronary Artery Disease

Preoperative serum cortisone levels are associated with cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: new evidence from human populations and mice

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