Assessment of the Developmental Toxicity of in Utero Exposure of Wistar Albino Rats to Ametryne and Niclosamide

Awad, Osama M.

doi:10.1006/pest.1995.1049

Cited by 11 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NCL is widely used to treat various metabolic disorders, cancers, viral infections, and immunological disturbance due to its pleiotropic effects antiviral and anti-inflammatory properties with modulation of uncoupling oxidative phosphorylation and various signaling pathways in human biological processes [ 10 ]. Several experimental studies confirmed that NCL is a safe and well-tolerated drug with a toxicity profile of more than 5 g/kg in rats [ 11 ]. NCL is well tolerated drug in humans, can be used orally at 2 g/day for worm treatment leading to serum concentrations of 0.25–6.0 µg/mL that corresponding to 0.76–18.35 µM respectively.…”

Section: Introductionmentioning

confidence: 99%

Niclosamide for Covid-19: bridging the gap

et al. 2021

View full text Add to dashboard Cite

Aim/purpose Niclosamide (NCL) is an anthelminthic drug, which is widely used to treat various diseases due to its pleiotropic anti-inflammatory and antiviral activities. NCL modulates of uncoupling oxidative phosphorylation and different signaling pathways in human biological processes . The wide-spectrum antiviral effect of NCL makes it a possible candidate for recent pandemic SARS-CoV-2 infection and may reduce Covid-19 severity. Therefore, the aim of the present study was to review and clarify the potential role of NCL in Covid-19. Methods This study reviewed and highlighted the protective role of NCL therapy in Covid-19. A related literature search in PubMed, Scopus, Web of Science, Google Scholar, and Science Direct was done. Results NCL has noteworthy anti-inflammatory and antiviral effects. The primary antiviral mechanism of NCL is through neutralization of endosomal PH and inhibition of viral protein maturation. NCL acts as a proton carrier, inhibits homeostasis of endosomal PH, which limiting of viral proliferation and release. The anti-inflammatory effects of NCL are mediated by suppression of inflammatory signaling pathways and release of pro-inflammatory cytokines. However, the major limitation in using NCL is low aqueous solubility, which reduces oral bioavailability and therapeutic serum concentration that reducing the in vivo effect of NCL against SARS-CoV-2. Conclusions NCL has anti-inflammatory and immune regulatory effects by modulating the release of pro-inflammatory cytokines, inhibition of NF-κB /NLRP3 inflammasome and mTOR signaling pathway. NCL has an anti-SARS-CoV-2 effect via interruption of viral life-cycle and/or induction of cytopathic effect. Prospective clinical studies and clinical trials are mandatory to confirm the potential role of NCL in patients with Covid-19 concerning the severity and clinical outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Niclosamide for Covid-19: bridging the gap

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Author: The results of Table indicated that niclosamide and it possible intermediate products (such as 5-chlorinated salicylic acid, 2-chlorine-4-nitroaniline, 2-chloro-4- nitrophenol, aminoniclosamide) would remain in the plant interior. According to previous studies, niclosamide was highly toxic to fish and amphibians, , 5-chlorinated salicylic acid had an effect on mutation and carcinogenesis, 2-chlorine-4-nitroaniline could produce a lower level of mutation than niclosamide, and 2-chlor-4-nitrophenol belongs to the high toxic organic compound, and its acute oral toxicity (LD50) to rats was 900 mg·kg –1 . Thus, we can conclude that there was a risk to edible plants when niclosamide was used.…”

Section: Resultsmentioning

confidence: 99%

Migration and Transformation Characteristics of Niclosamide in a Soil–Plant System

Luo

Huang

et al. 2018

ACS Omega

View full text Add to dashboard Cite

The molluscicide niclosamide is found in most of the wetlands of China. The migration and transformation pathways, and degradation kinetics of niclosamide in the plant–soil system was analyzed by with the use of potting experiment. Experimental results showed that degradation of niclosamide in rhizosphere soil fit the first-order kinetics, and microorganisms played an important role in the degradation of niclosamide. It was found that niclosamide degrades to form a series of aromatic intermediate products both in soil and plants. Niclosamide could be absorbed from soil to plant by the root and then migrate to the stem. At an initial concentration of niclosamide of 2.11 mg·kg–1 in soil, the maximum residue of niclosamide in Artemisia somai aerial was 2.47 mg·kg–1 after 10 days of cultivation. This value is close to the pollution maximum residue limit (3 mg·kg–1) in rice, and niclosamide and its intermediates can remain about 43 days in plants. The experimental results demonstrate that the use of niclosamide in wetlands would have some risk in edible plants and was harmful for human health.

show abstract

“…These findings are contrary to another report that indicates that Nic (at doses as high as 200 mg/kg body weight, oral) does not affect reproductive function and does not affect the number, size, or development of pups in pregnant mice [ 55 ]. An early report in rats also suggests that Nic treatment (80 mg/kg body weight, oral) in pregnant rats does not greatly affect the development of fetuses [ 56 ]. Moreover, the World Health Organization data sheet on Nic indicates that doses of up to 44 mg/kg body weight i.p.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy-associated Steroid Effects on Insulin Sensitivity, Adipogenesis, and Lipogenesis: Role of Wnt/β-Catenin Pathway

Alex

Khan

Ramachandra

et al. 2023

Journal of the Endocrine Society

View full text Add to dashboard Cite

The shift in maternal energy metabolism characteristic of pregnancy is thought to be driven by various hormonal changes, especially of ovarian and placental steroids. Imbalances in circulating estradiol (E2) and progesterone (P4) levels during this period are often associated with metabolic disturbances leading to development of gestational diabetes mellitus (GDM). Since abnormalities in the Wnt pathway effector TCF7L2 are commonly associated with occurrence of GDM, we hypothesized that the canonical or β-catenin-dependent Wnt signaling pathway mediates the metabolic actions of E2 and P4. In the present study, we observed that E2 enhanced insulin sensitivity and inhibited lipogenesis while P4 increased lipogenic gene expression – in 3T3-L1 adipocytes, and in adipose tissue and skeletal muscle of ovariectomized (OVX) rats when the dosage of E2 and P4 mimicked that of pregnancy. Both E2 and P4 were also found to up-regulate Wnt signaling. We used niclosamide (Nic) to inhibit the steroid-mediated increase in Wnt signaling in adipocytes and OVX rats, to test our hypothesis. The insulin-sensitizing and anti-lipogenic actions of E2 were found to be mediated by the canonical Wnt pathway, but the effects of P4 on lipogenesis appeared to be independent of it. Additionally, it was observed that inhibition of Wnt signaling by Nic hastened adipogenic differentiation, and the inhibitory effect of E2 on differentiation was prevented by Nic. The findings presented in this study highlight the role of steroids and Wnt pathway in glucose and lipid metabolism and are relevant in understanding the pathophysiology of metabolic disorders arising from hormonal disturbances.

show abstract

Assessment of the Developmental Toxicity of in Utero Exposure of Wistar Albino Rats to Ametryne and Niclosamide

Cited by 11 publications

References 0 publications

Niclosamide for Covid-19: bridging the gap

Niclosamide for Covid-19: bridging the gap

Migration and Transformation Characteristics of Niclosamide in a Soil–Plant System

Pregnancy-associated Steroid Effects on Insulin Sensitivity, Adipogenesis, and Lipogenesis: Role of Wnt/β-Catenin Pathway

Contact Info

Product

Resources

About