Assessment of the direct cyclotron production of 99mTc: An approach to crisis management of 99mTc shortage

Rovais, Mohammad Reza Aboudzadeh; Aardaneh, K.; Aslani, Gholamreza; Rahiminejad, Ali; Yousefi, Kamran; Boulouri, Fatemeh

doi:10.1016/j.apradiso.2016.03.017

Cited by 17 publications

(8 citation statements)

References 13 publications

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“…The final efficiency of 100 Mo recycling is above 90%. Other research groups have produced data on similar experiments that concur with these results (Das et al, 2016 ; Rovais et al, 2016 ).…”

Section: Developments In Radionuclide Productionsupporting

confidence: 69%

Production of novel diagnostic radionuclides in small medical cyclotrons

Synowiecki

Perk

Nijsen

2018

EJNMMI radiopharm. chem.

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The global network of cyclotrons has expanded rapidly over the last decade. The bulk of its industrial potential is composed of small medical cyclotrons with a proton energy below 20 MeV for radionuclides production. This review focuses on the recent developments of novel medical radionuclides produced by cyclotrons in the energy range of 3 MeV to 20 MeV. The production of the following medical radionuclides will be described based on available literature sources: Tc-99 m, I-123, I-124, Zr-89, Cu-64, Ga-67, Ga-68, In-111, Y-86 and Sc-44. Remarkable developments in the production process have been observed in only some cases. More research is needed to make novel radionuclide cyclotron production available for the medical industry.

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Section: Developments In Radionuclide Productionsupporting

confidence: 69%

Production of novel diagnostic radionuclides in small medical cyclotrons

Synowiecki

Perk

Nijsen

2018

EJNMMI radiopharm. chem.

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“…In recent years, several groups, including our consortium, developed new targets and robust separation procedures to manufacture high-purity 99m Tc with cyclotrons (7,(15)(16)(17)(18)(19)(20). There is increasingly convincing evidence that the quality of cyclotron-produced 99m Tc is comparable to that of conventional 99m Tc (6,7,21,22,23) and that sufficient quantities can be made to satisfy the demand of large urban communities (3).…”

Section: Discussionmentioning

confidence: 99%

Clinical Trial with Sodium ^99mTc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function

Selivanova¹,

Lavallée

Senta

et al. 2016

J Nucl Med

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A single-site prospective open-label clinical study with cyclotron-produced sodium Tc-pertechnetate (Tc-NaTcO) was performed in patients with indications for a thyroid scan to demonstrate the clinical safety and diagnostic efficacy of the drug and to confirm its equivalence with conventional Tc-NaTcO eluted from a generator. Tc-NaTcO was produced from enriched Mo (99.815%) with a cyclotron (24 MeV; 2 h of irradiation) or supplied by a commercial manufacturer (bulk vial eluted from a generator). Eleven patients received 325 ± 29 (mean ± SD) MBq of the cyclotron-producedTc-NaTcO, whereas the age- and sex-matched controls received a comparable amount of the generator-derived tracer. Whole-body and thyroid planar images were obtained for each participant. In addition to the standard-energy window (140.5 keV ± 7.5%), data were acquired in lower-energy (117 keV ± 10%) and higher-energy (170 keV ± 10%) windows. Vital signs and hematologic and biochemical parameters were monitored before and after tracer administration. Cyclotron-producedTc-NaTcO showed organ and whole-body distributions identical to those of conventional Tc-NaTcO and was well tolerated. All images led to a clear final diagnosis. The fact that the number of counts in the higher-energy window was significantly higher for cyclotron-produced Tc-NaTcO did not influence image quality in the standard-energy window. Image definition in the standard-energy window with cyclotron-produced Tc was equivalent to that with generator-elutedTc and had no particular features allowing discrimination between the Tc production methods. The systemic distribution, clinical safety, and imaging efficacy of cyclotron-produced Tc-NaTcO in humans provide supporting evidence for the use of this tracer as an equivalent for generator-eluted Tc-NaTcO in routine clinical practice.

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“…The direct production of 99m Tc on cyclotrons, involving the proton bombardment of a solid 100 Mo source in the 100 Mo(p,2n) 99m Tc reaction, is now a reality [23,27,28].…”

Section: Techentium-99m Production Routesmentioning

confidence: 99%

A Picture of Modern Tc-99m Radiopharmaceuticals: Production, Chemistry, and Applications in Molecular Imaging

2019

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Even today, techentium-99m represents the radionuclide of choice for diagnostic radio-imaging applications. Its peculiar physical and chemical properties make it particularly suitable for medical imaging. By the use of molecular probes and perfusion radiotracers, it provides rapid and non-invasive evaluation of the function, physiology, and/or pathology of organs. The versatile chemistry of technetium-99m, due to its multi-oxidation states, and, consequently, the ability to produce a variety of complexes with particular desired characteristics, are the major advantages of this medical radionuclide. The advances in technetium coordination chemistry over the last 20 years, in combination with recent advances in detector technologies and reconstruction algorithms, make SPECT’s spatial resolution comparable to that of PET, allowing 99mTc radiopharmaceuticals to have an important role in nuclear medicine and to be particularly suitable for molecular imaging. In this review the most efficient chemical methods, based on the modern concept of the 99mTc-metal fragment approach, applied to the development of technetium-99m radiopharmaceuticals for molecular imaging, are described. A specific paragraph is dedicated to the development of new 99mTc-based radiopharmaceuticals for prostate cancer.

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Assessment of the direct cyclotron production of 99mTc: An approach to crisis management of 99mTc shortage

Cited by 17 publications

References 13 publications

Production of novel diagnostic radionuclides in small medical cyclotrons

Production of novel diagnostic radionuclides in small medical cyclotrons

Clinical Trial with Sodium ^99mTc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function

A Picture of Modern Tc-99m Radiopharmaceuticals: Production, Chemistry, and Applications in Molecular Imaging

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Assessment of the direct cyclotron production of 99mTc: An approach to crisis management of 99mTc shortage

Cited by 17 publications

References 13 publications

Production of novel diagnostic radionuclides in small medical cyclotrons

Production of novel diagnostic radionuclides in small medical cyclotrons

Clinical Trial with Sodium 99mTc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function

A Picture of Modern Tc-99m Radiopharmaceuticals: Production, Chemistry, and Applications in Molecular Imaging

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Product

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About

Clinical Trial with Sodium ^99mTc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function