Assessment of the Effect of Pyridoxine Hydrochloride Supplementation on Anthropometric Measurements, Body Composition, Visceral Adiposity Index and Metabolic Status in Obese and Overweight Women

Abstract

<jats:title>Abstract</jats:title> <jats:p><jats:bold>Background and Objectives: </jats:bold>Obesity has reached epidemic proportions globally. Among several methods for treating obesity, the use of dietary supplements is common recently. One supplement that can help in this regard might be vitamin B6 in high doses.The objective of this study was to evaluate the efficacy of pyridoxine hydrochloride supplementation on anthropometric measurements, body composition, visceral adiposity index and metabolic status in obese and overweight women.<jats:bold>Methods and Study Design:</jats:bold> In this randomized controlled clinical trial, 44 obese and overweight women aged 18–50 years were selected and divided randomly into two groups: an intervention group (receiving 80 mg pyridoxine hydrochloride supplement for 8 weeks) and control group (receiving placebo for 8 weeks). <jats:bold>Results:</jats:bold> In the pyridoxine hydrochloride group, weight(p=0.01), body mass index(p=0.009), fat mass(p=0.003), waist circumference(p=0.005), visceral adiposity index(p=0.001), fasting insulin, Insulin Resistance(HOMA-IR), Total cholesterol, low density lipoprotein(LDL), Triglycerides (TG) and leptin(p&lt;0.001) decreased whereas adiponectin(p&lt;0.001) increased in comparison to the baseline values. There was a significant difference in fat mass, visceral adiposity index, fasting insulin, HOMA-IR and TG between pyridoxine hydrochloride and control groups following intervention in adjusted models(p&lt;0.05).<jats:bold>Conclusions: </jats:bold>The findings suggest that vitamin B6 supplementation may be effective in reducing BMI and improving body composition and biochemical factors associated with obesity.<jats:bold>Trial registration:</jats:bold> The trial was approved by the Ethics Committee of Ahvaz Jundishapur University of Medical Sciences (reference number: ir.ajums.rec.1394.254) and was registered at Iranian Registry of Clinical Trials (code: IRCT20181002041206N1).</jats:p>

Impact of Pyridoxine Supplement on Oxidative Stress in Type 2 Diabetic Patients

“…Previous studies have found that pyridoxine supplementation can effectively raise PLP levels in this population (24,37). A study found that supplementation significantly increased PLP levels compared to placebo, suggesting that pyridoxine supplementation 150 mg/day for 4 months can effectively raise PLP levels (24.25 nmol/L to 156.25 nmol/L) (38) (33). The result of current study (23.14 nmol/L to 40.77 nmol/L) in agreement with previous study.…”

“…Some studies included participants with a positive family history of diabetes, indicating a genetic predisposition to the disease. This allowed researchers to explore whether the effects of pyridoxine on glycemic status, BMI, metabolic activity, lipid profile, and oxidative stress in T2DM may vary in individuals with a familial risk compared to those without such a history (33,34). The duration of morbidity with T2DM, referring to the length of time since the initial diagnosis, has been a crucial characteristic in previous studies.…”