Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

Azarbarz, Nastaran; Seifabadi, Zeinab Shafiei; Moaiedi, Maasoumeh Zare; Mansouri, Esrafil

doi:10.1007/s11356-019-07266-5

Cited by 19 publications

(13 citation statements)

References 44 publications

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“…They also showed that rutin co‐treatment could ameliorate a decrease in sperm production, cell number and tubule diameter. Similarly, Azarbarz et al., (2020) revealed that CP treatment significantly decreased the diameter of the seminiferous tubules, germinal epithelium thickness, the number of spermatogonia, spermatocyte and Sertoli cells. In another study, semiquantitative data of Afsar et al., (2017) revealed that CP caused a reduction in the number of Leydig cells inducing the degradation in Leydig cells.…”

Section: Discussionmentioning

confidence: 78%

“…Oxidative stress causes testicular damage, testicular apoptosis, DNA damage and male reproductive dysfunction, which can result in infertility (Shati, 2019). Previous studies have reported that CP treatment caused the increased in level of lipid peroxidation and the decreased in level of SOD, CAT and GSH (Azarbarz et al, 2020;Reddy et al, 2016). Similarly, Afsar et al, (2017) reported that CP increased the level of oxidative stress parameters, while decreased the activity of antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…Cisplatin (CP) is a powerful antineoplastic drug widely used to treat various cancers such as bladder, lung, and testis cancer (Azarbarz et al., 2020). The anti‐tumour effect of CP, a DNA‐alkylating molecule, prevents the replication and transcription of DNA by breaking the DNA double strands (Ahmed et al., 2011).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of protective effects of gallic acid on cisplatin‐induced testicular and epididymal damage

Altındağ

Meydan

2021

Andrologia

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The current study explored the bene cial effects of GA against testis and epididymis toxicity induced by CP treatment. Male rats were into 4 groups (n=7). Control (saline, intraperitoneal), Cisplatin (a single dose of 8 mg/kg/day cisplatin, intraperitoneal), Gallic acid (50 mg/kg Gallic acid orally for 10 days) and Cisplatin+Gallic acid groups. Total number of spermatogonia, Sertoli, Leydig cell and the total volume of testis, seminiferous tubule, interstitial area, and germinal epithelial thickness and numerical densities of caspase-3, Bax, Bcl-2, 8-OHdG immunopositive cells were calculated. Histopathological examination of the testis and epididymis was performed. MDA and CAT levels are measured in the testis. Also, the testosterone level was measured in the serum of the rats. As a result, a signi cant decrease was observed in all stereological data, Bcl-2 immunopositive cell number, CAT, and serum testosterone levels in the testis compared to the CP group control group, while a signi cant increase was observed in the number of caspase-3, Bax, and 8-OHdG immunopositive cells and the level of MDA. However, GA signi cantly improved these parameters. Our study reveals that GA may improve CP-induced male reproductive toxicity by reducing oxidative stress, suppressing apoptosis and DNA damage, and restoring structural and functional deterioration.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Evaluation of protective effects of gallic acid on cisplatin‐induced testicular and epididymal damage

Altındağ

Meydan

2021

Andrologia

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“…Sulfides in garlic regulate the secretion of testosterone by affecting the secretion of luteinizing hormone (LH), indicating that H 2 S may play an important role in the secretion of testosterone (67). Similarly, in rat testis, the provision of NaHS protected the testis from oxidative stress and inflammation induced by cisplatin and increased the activity of antioxidant enzymes (68). Subsequently, it has been found that the expression of CBS decreases in the spermatozoa of human asthenospermic patients, and AOAA inhibited the sperm motility, then the addition of GYY4137 weakens the effect of AOAA, suggesting that H 2 S could promote the production and activity of spermatozoa (69).…”

Section: The Function Of H 2 S In Gonadsmentioning

confidence: 99%

Role of Hydrogen Sulfide in the Endocrine System

et al. 2021

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Hydrogen sulfide (H2S), as one of the three known gaseous signal transduction molecules in organisms, has attracted a surging amount of attention. H2S is involved in a variety of physiological and pathological processes in the body, such as dilating blood vessels (regulating blood pressure), protecting tissue from ischemia-reperfusion injury, anti-inflammation, carcinogenesis, or inhibition of cancer, as well as acting on the hypothalamus and pancreas to regulate hormonal metabolism. The change of H2S concentration is related to a variety of endocrine disorders, and the change of hormone concentration also affects the synthesis of H2S. Understanding the effect of biosynthesis and the concentration of H2S on the endocrine system is useful to develop drugs for the treatment of hypertension, diabetes, and other diseases.

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“…Cisplatin (CIS) is an effective chemotherapy drug for the treatment of testicular cancer, gynecologic cancer, gastrointestinal cancer, and malignant diseases (Albany et al., 2021). However, there are numerous side‐effects during CIS treatment (Azarbarz et al., 2020), especially testicular toxicity (Wang, Lai, et al, 2020). Exposure to CIS led to testicular atrophy and decrease in the number, viability, and motility of sperm, resulting in spermatogenesis inhibition and infertility (Fouad et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Grape seed proanthocyanidin extract ameliorates cisplatin‐induced testicular apoptosis via PI3K/Akt/mTOR and endoplasmic reticulum stress pathways in rats

et al. 2021

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Testicular toxicity is an adverse reaction of the effective chemotherapy drug cisplatin (CIS). Our previous study found that grape seed proanthocyanidin extract (GSPE) had a protective effect on CIS‐induced testicular toxicity. However, the protective mechanism of GSPE against CIS‐induced testicular toxicity remains unknown. In this study, we aimed to investigate whether GSPE can reduce CIS‐induced testicular toxicity and its potential mechanism in rats. The results showed that GSPE ameliorated CIS‐induced the apoptosis of testicular cells and inhibited the protein levels of Bad, Cyt c, caspase‐9, caspase‐3, caspase‐12, GRP78, CHOP, IRE1α, p‐IRE1α, XBP‐1S, PERK, p‐PERK, eIF2α, and p‐eIF2α. Besides, GSPE reversed the downregulation of PI3K, p‐PI3K, Akt, p‐Akt, mTOR, and p‐mTOR protein expression induced by CIS. These results indicated that GSPE can improve CIS‐induced testicular cells apoptosis via activating PI3K/Akt/mTOR and inhibiting Bad/Cyt c/caspase‐9/caspase‐3 pathways. And GSPE relieved endoplasmic reticulum stress‐mediated apoptosis via inhibiting PREK/eIF2α and IRE1α/XBP‐1S/caspase‐12 pathways. In conclusion, the evidence suggested that GSPE can act as a protective agent against testicular toxicity induced by CIS. Practical applications Testicular toxicity was a well‐known adverse effect of cisplatin (CIS) in cancer treatment. Grape seed proanthocyanidin extract (GSPE) has been reported to serve as one of the most therapeutic potentials agents. In present study, we explored the regulatory effects of GSPE on the apoptosis induced by CIS, which involved testicular apoptosis mechanisms in rats. Our results indicated that CIS caused testicular toxicity via PI3K/AKT/mTOR and ERS mediated apoptosis pathway in rats. This toxicity was attenuated by GSPE treatment via activated PI3K/Akt/mTOR pathway, and inhibiting Bad/CytC/caspase‐9/caspase‐3 as well as PREK/eIF2α, IRE1α/XBP‐1S/caspase‐12 pathways. Our findings suggest that GSPE may be a novel protective agent against testicular toxicity induced by CIS.

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Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats

Cited by 19 publications

References 44 publications

Evaluation of protective effects of gallic acid on cisplatin‐induced testicular and epididymal damage

Evaluation of protective effects of gallic acid on cisplatin‐induced testicular and epididymal damage

Role of Hydrogen Sulfide in the Endocrine System

Grape seed proanthocyanidin extract ameliorates cisplatin‐induced testicular apoptosis via PI3K/Akt/mTOR and endoplasmic reticulum stress pathways in rats

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