2015
DOI: 10.1055/s-0035-1557833
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Assessment of the Effect of Arbutin Isomers and Kojic Acid on Melanin Production, Tyrosinase Activity, and Tyrosinase Expression in B16-4A5 and HMV-II Melanoma Cells

Abstract: !The inhibitory effects of α-arbutin, β-arbutin, and kojic acid on melanogenesis, tyrosinase activity, and tyrosinase protein expression in mouse melanoma cells (B16-4A5) and human melanoma cells (HMV-II) were directly compared. β-Arbutin showed a stronger inhibitory effect on melanogenesis and tyrosinase expression in B16-4A5 cells than α-arbutin and kojic acid. Kojic acid showed a stronger inhibitory effect on mushroom and B16-4A5 tyrosinase activity than α-arbutin and β-arbutin. In contrast, kojic acid inhi… Show more

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(5 citation statements)
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“…Some articles evaluated kojic acid and/or its derivatives applying both methods (inhibition of tyrosinase and melanin content). 18,29,34,[41][42][43] Benzoate ester derivatives were tested, and, while compounds without adamantane moiety inhibited mushroom tyrosinase but did not inhibit melanin synthesis, the ones with adamantane moiety did otherwise, which is probably related to the differences between the amino acid…”
Section: Moleculementioning
confidence: 99%
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“…Some articles evaluated kojic acid and/or its derivatives applying both methods (inhibition of tyrosinase and melanin content). 18,29,34,[41][42][43] Benzoate ester derivatives were tested, and, while compounds without adamantane moiety inhibited mushroom tyrosinase but did not inhibit melanin synthesis, the ones with adamantane moiety did otherwise, which is probably related to the differences between the amino acid…”
Section: Moleculementioning
confidence: 99%
“…The IC50 inhibition value for HMV-II was 223.8 μM and concentrations between 125 and 1000 μM suppressed melanogenesis in a concentration-dependent manner, suggesting that kojic acid acts in human cells suppressing melanogenesis due to the inhibition of tyrosinase. 42 Lajis and coworkers (2012) 18 tested kojic acid esters regarding tyrosinase activity using mushroom tyrosinase and murine B16F1 melanoma cells and compared to kojic acid itself. In both types of enzymes, the kojic acid esters were not significantly different than kojic acid; melanin content results were similar to those of tyrosinase inhibition.…”
Section: Moleculementioning
confidence: 99%
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