Assessment of the effect of gasoline fume on stress hormones, antioxidant status and lipid peroxidation in albino rat

Owagboriaye, Folarin; Dedeke, G. A.; Aladesida, Adeyinka; Bamidele, Julius Akolawole; Olooto, Wasiu Eniola

doi:10.1016/j.jksus.2016.11.002

Cited by 22 publications

(11 citation statements)

References 33 publications

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“…Decreased spermatogonia also causes male infertility. In line with our findings, a study on 40 albino mice found that exposure to liquid gasoline for six hours a day for 12 weeks reduced sperm motility as well as increased the number of abnormal sperms (no head, twisted tail, damaged head) (20). It was also shown that oral exposure to gasoline, decreased daily sperm production, sperm number in the caput/corpus epididymis, progressive motility, mitochondrial activity, and acrosomal membrane integrity (21).…”

Section: Discussionsupporting

confidence: 89%

The Effects of Gasoline Vapor Inhalation on Serum Level of Testosterone and Testes Tissue in Male Rats

Ahmadi

Mirbahari

vahed

2020

CJHR

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Background: Studies show that gasoline inhalation has severe damage on certain tissues in body. This study aimed to determine the effects of gasoline vapor inhalation on serum testosterone level and testes tissue in male rats. Methods: Male Wistar rats were randomly divided into control and experimental groups exposed to gasoline vapor for 1, 2 or 3 h/day of 5 rats in each group. After 12 weeks, blood samples were collected using the cardiac puncture method. Serum testosterone was measured using the radioimmunoassay method. Testes tissue was examined histologically using Hematoxylin and Eosin staining method. Data were analyzed using one way-ANOVA. Results: Serum testosterone level significantly increased in rats exposed to gasoline vapor for 1, 2, 3 hours/day compared with control group. The number of spermatogonia cells significantly decreased in experimental groups compared to control rats; However, the number of spermatocytes and Sertoli cells, and the seminiferous tunnel diameter did not significantly change in groups exposed to gasoline vapor compared with control rats. Conclusion: Inhalation of gasoline vapor had deleterious effects on testis tissue, resulting in decreased number of spermatogonia cells and increased serum testosterone level.

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Section: Discussionsupporting

confidence: 89%

The Effects of Gasoline Vapor Inhalation on Serum Level of Testosterone and Testes Tissue in Male Rats

Ahmadi

Mirbahari

vahed

2020

CJHR

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“…60,61 We have also associated a high level of lipid peroxidation with decreased antioxidant enzyme activities. 62 McCord 63 reported that under acute oxidative stress, the toxic effects of pollutants may overwhelm the antioxidant defense system. Roundup herbicide formulation could, therefore, be strong enough to force an acute oxidative stress on the normal kidney physiology by overwhelming and depleting its antioxidant defense system.…”

Section: Mg/kg Bw Of Glyphosate Concentrationmentioning

confidence: 99%

Comparative Assessment on Mechanism Underlying Renal Toxicity of Commercial Formulation of Roundup Herbicide and Glyphosate Alone in Male Albino Rat

et al. 2018

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There have been major concerns that the nephrotoxicity of commercial formulations of Roundup herbicide is due to the active ingredient glyphosate. We therefore investigated and compared the mechanisms underlining the nephrotoxicity of Roundup herbicide and glyphosate alone in rat. Fifty-six adult male rats randomized into 7 groups of 8 rats per group were exposed to Roundup formulation and glyphosate alone daily by gavage at 3.6, 50.4, and 248.4 mg/kg body weight (bw) of glyphosate concentrations for 12 weeks with distilled water administered to the control group. Kidney biomarker (serum urea and creatinine, plasma cystatin-C, and neutrophil gelatinase-associated lipocalin), oxidative stress indices in the kidney tissue, activities of kidney membrane-bound enzymes (Mg-adenosine triphosphatase [ATPase], Ca-ATPase, Na/K-ATPase, and total ATPase), and histopathological changes in the kidney were monitored. Glyphosate concentration in the kidney was quantified by high-performance liquid chromatography with ultraviolet detection. Significant ( P < 0.05) alterations in the levels of the kidney biomarker, oxidative stress markers, and membrane-bound enzymes were observed in the rats exposed to Roundup compared to the rats exposed to glyphosate alone. Rats exposed to Roundup accumulated more glyphosate residue in their kidney tissue. Severe histopathological lesions were only seen in the kidneys of rats exposed to Roundup. The nephrotoxicity observed cannot be due to the active ingredient in the Roundup formulation, as glyphosate alone has virtually no effect on the renal function of the exposed animals. Therefore, the general claim attributing nephrotoxicity of a glyphosate-based herbicide to its active ingredient should be discouraged.

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“…Exposure to petroleum products both in and outside petroleum industries have been reported to have some effects on the users, with those who are occupationally exposed being more likely to be affected than their counterparts [5,6,7]. Such effects include increased incidences of blood disorders and anemia, higher cancer risk, renal function impairment, and nephrotoxicity [8,9,5,10].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Effects of Petrol, Xylene and Thinner on Mus musculus (Albino Mice)

Kemabonta

Ikerodah

Anumud

2020

PAJOLS

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Background: Petrol, xylene, and thinner are volatile organic compounds (VOCs), a major class of pollutants that affect the chemistry of the atmosphere and animals including man. The principal mode of contamination is via inhalation. This study aims to elucidate the effects of these compounds on bio-chemical functions in the body of the mouse, Mus musculus Methods: One hundred and twenty adult albino Mus musculus species were randomly assigned to groups (A1, A2, B1, B2, C1, C2, and D1) based on their weights (8-13g for juveniles and 15 – 21g for adults) with specific treatments. The control treatment, A1, was housed in a plastic experimental house free from the test chemical vapor while groups A2 and B1; B2 and C1; C2 and D1 were exposed to pet-rol, thinner, and xylene respectively in wooden exposure chambers for six hours daily for sixty days. Levels of oxidative stress markers (GSH, SOD, CAT, and MDA) were determined using the spectrophotometry. Results: A significant decrease in the values of GSH, activities of SOD and CAT, were observed when compared to the mice in the control experiment as daily exposure to the selected vapor increased. On the other hand, MDA levels increased significantly with increasing daily exposure to vapor from the test chemicals, when compared to the control rats. Conclusion: Based on the findings from this study, the decrease in the SOD, CAT and GSH levels are indications of toxic build up in the blood implying that exposures to these VOCs inhibit natural processes. Thus, VOCs are detrimental to human health and long-term exposure to these organic com-pounds could result in deleterious sub-lethal effects, especially to individual exposed occupationally to them

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Assessment of the effect of gasoline fume on stress hormones, antioxidant status and lipid peroxidation in albino rat

Cited by 22 publications

References 33 publications

The Effects of Gasoline Vapor Inhalation on Serum Level of Testosterone and Testes Tissue in Male Rats

The Effects of Gasoline Vapor Inhalation on Serum Level of Testosterone and Testes Tissue in Male Rats

Comparative Assessment on Mechanism Underlying Renal Toxicity of Commercial Formulation of Roundup Herbicide and Glyphosate Alone in Male Albino Rat

Toxicological Effects of Petrol, Xylene and Thinner on Mus musculus (Albino Mice)

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