Assessment of the effects of lacosamide on sleep parameters in healthy subjects

Hudson, John; Guptill, Jeffrey T.; Byrnes, William; Yates, Stephen L.; Williams, Paulette; D’Cruz, O’Neill F.

doi:10.1016/j.seizure.2014.10.012

Cited by 13 publications

(5 citation statements)

References 33 publications

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“…However, the study’s short duration and the recruitment from a single site limit the generalization of these findings. This innocent role of LCS in sleep is supported by previously published class III research in healthy individuals 67 .…”

Section: Resultssupporting

confidence: 73%

Effects of antiepileptic drugs on sleep architecture parameters in adults

Carvalho¹,

Chaves²,

Silva³

2022

Sleep Sci

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Objectives Physiological and restorative sleep is fundamental for physical and mental well-being. Polysomnography parameters are objective methods to access sleep structure. Antiepileptic drugs (AEDs) are a group of drugs whose interference in the sleep structure is still not well known, especially in what concern the new ones. We did a systematic review of the literature to compare the effect of classic and newer AEDs on sleep architecture. Material and Methods A search was performed in PubMed and Scopus, using keywords “sleep” and “antiepileptics”, and each AED combined with “sleep”. Only studies concerning objective measures were selected. Results 63 articles were included, only 21 were randomized, controlled and double-blinded. Studies not only in epilepsy, but also in restless leg syndrome, bruxism, insomnia, fibromyalgia and obstructive sleep apnea were found. Among classic AEDs, carbamazepine has a negative effect on sleep while phenobarbitone has a slightly dose-dependent interference and is also the only one to reduce N3 stage. Valproic acid has little to no effect while clobazam and clonazepam have a positive effect. No conclusion can be drawn about phenytoin. All of them reduce REM stage. In the newer AEDs group gabapentine, lamotrigine, perampanel, pregabaline and tiagabine increase N3 sleep in best evidence. Lacosamide and zonisamide appear to be innocent while levetiracetam reduces REM sleep. Conclusion Studies found used different methodologies not always addressing the analysis on the same parameters. In spite of these, newer AEDs have less effects on sleep structure when compared with classic AEDs but furthermore robust evidence is needed.

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Section: Resultssupporting

confidence: 73%

Effects of antiepileptic drugs on sleep architecture parameters in adults

Carvalho¹,

Chaves²,

Silva³

2022

Sleep Sci

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“…Lacosamide (LCM) caused no apparent change on sleep in healthy individuals at a dosage of 300 mg per day. 19 Similarly, no change in excessive sleepiness scores or Pittsburgh Sleep Quality Index scores was found in ten patients with drugresistant focal epilepsy who took LCM for 6 months. 20 In nocturnal frontal lobe epilepsy with sleep disorders, the patients had positive clinical responses to LCM at a dose of 200 mg/day.…”

Section: Voltage-gatedionchannelblockadementioning

confidence: 92%

“…Although LTG rarely causes sedative effect, approximately 60% of the patients on LTG reported insomnia, 17 which should be taken into consideration during drug titration. Lacosamide (LCM) caused no apparent change on sleep in healthy individuals at a dosage of 300 mg per day 19 . Similarly, no change in excessive sleepiness scores or Pittsburgh Sleep Quality Index scores was found in ten patients with drug‐resistant focal epilepsy who took LCM for 6 months 20 .…”

Section: Anti‐seizure Medicationsmentioning

confidence: 99%

Effects of anti‐seizure therapies on sleep in patients with epilepsy: A literature review

Chen

et al. 2022

Acta Neuro Scandinavica

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Sleep disorder is common in epilepsy. With a recent rapid development in sleep medicine, it has been increasingly recognized that anti‐seizure therapies, either anti‐seizure medications (ASMs) or non‐pharmaceutical approaches, can take direct or indirect influence on sleep in patients with epilepsy. Here, we systematically review the effect of anti‐seizure treatments on sleep. ASMs targeting at different sites exerted various effects on both sleep structure and sleep quality. Non‐pharmaceutical treatments including resective surgery, ketogenic diet, and transcranial magnetic stimulation appear to have a positive effect on sleep, while vagus nerve stimulation, deep brain stimulation, and brain‐responsive neurostimulation are likely to interrupt sleep and exacerbate sleep‐disordered breathing. The potential mechanisms underlying how non‐pharmacological approaches affect sleep are also discussed. The limitation of most studies is that they were largely based on small cohorts by short‐term observations. Further well‐designed and large‐scale investigations in this field are warranted. Understanding the effect of anti‐seizure therapies on sleep can guide clinicians to optimize epilepsy treatment in the future.

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“…Lacosamide 300 mg/day had no effect on objective or subjective sleep parameters in healthy subjects and was generally well tolerated (32,33).…”

Section: Antiepileptic Agentsmentioning

confidence: 98%

Untitled

2018

Ro J Neurol.

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There are many medications that cross the blood-brain barrier affecting the central nervous system and converting the normal patterns of sleep and wakefulness. Some drugs are used to treat special sleep disorders but others can induce sleep disorders (e.g. periodic limb movements during sleep, restless leg syndrome, parasomnia, insomnia) or exacerbate them (e.g. obstructive or central sleep apnea). The most frequent classes of agents used in sleep medicine are: benzodiazepines, nonbenzodiazepines receptor agonists, melatonin and melatonin receptor agonists, antiepileptic drugs, antidepressants, atypical antipsychotics, central stimulants and dopamine agonists.

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Assessment of the effects of lacosamide on sleep parameters in healthy subjects

Abstract: Lacosamide 300 mg/day had no effect on objective or subjective sleep parameters in healthy subjects and was generally well tolerated.

Cited by 13 publications

References 33 publications

Effects of antiepileptic drugs on sleep architecture parameters in adults

Effects of antiepileptic drugs on sleep architecture parameters in adults

Effects of anti‐seizure therapies on sleep in patients with epilepsy: A literature review

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