Assessment of the Efficacy and Safety of a Combination of 2 Topical Retinoids (RetinSphere) in Maintaining Post-Treatment Response of Acne to Oral Isotretinoin

Truchuelo, M.T.; Jiménez, N.; Mavura, Daudi; Jaén, P.

doi:10.1016/j.adengl.2014.09.018

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…In recent studies, adapalene 0.1%, tretinoin 0.04% gel, adapalene 0.1%/benzoyl peroxide 2.5% combined gel, and two different topical retinoid combinations were used once per day for at least 3 months, 6 months, and 1 year after the isotretinoin. The relapse rates in these studies are quite low 28,30–33 . In our study, adapalene 0.1% cream was used as topical maintenance therapy, but there was no difference in relapse rates in patients who received topical maintenance therapy compared with those who did not.…”

Section: Discussionmentioning

confidence: 50%

“…The relapse rates in these studies are quite low. 28,[30][31][32][33] In our study, adapalene 0.1% cream was used as topical maintenance therapy, but there was no difference in relapse rates in patients who received topical maintenance therapy compared with those who did not. The effectiveness of topical maintenance therapy on relapse cannot be fully determined in this study because it was used in a small number of patients.…”

Section: Resultsmentioning

confidence: 99%

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Investigation of relapse rate and factors affecting relapse after oral isotretinoin treatment in patients with acne vulgaris

Saadet

2021

Dermatologic Therapy

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Oral isotretinoin is the most effective treatment option used in acne treatment. However, varying rates of relapse have been reported after oral isotretinoin therapy. The aim of this study was to evaluate factors that affect relapse after oral isotretinoin treatment in patients with acne. In this cross-sectional study, 212 patients with acne using 0.3-1 mg/kg/day oral isotretinoin for at least 4 months were analyzed retrospectively regarding relapse frequency and factors that affected relapse. In the study, the female-to-male ratio was 3.15, with a mean age of 23.5 ± 6.2 years. The relapse rate was found as 37.3%. The median time to relapse was 10 months. The relapse rate was higher in younger patients (age ≤ 20 years), macrocomedone-type acne, and those with residual lesions at the end of the treatment (p < 0.05 and p < 0.01, respectively). To prevent relapse in patients with acne using oral isotretinoin, it is of great importance to continue the treatment until complete clinical improvement, and extend the treatment for at least one more month regardless of the cumulative dose. Relapse may also occur with younger age and macrocomedone-type acne.

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Section: Discussionmentioning

confidence: 50%

Section: Resultsmentioning

confidence: 99%

Investigation of relapse rate and factors affecting relapse after oral isotretinoin treatment in patients with acne vulgaris

Saadet

2021

Dermatologic Therapy

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“…Truchuelo et al . reported the use of the 9‐item Social Quality‐of‐Life (SOQOL) scale, citing Krejci‐Manwaring et al .…”

Section: Resultsmentioning

confidence: 99%

Quality of life measurement in acne. Position Paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

Chernyshov

Zouboulis

Tómas-Aragonés

et al. 2017

Acad Dermatol Venereol

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Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment in acne and because of the high impact of acne on patients' lives, the European Academy of Dermatology and Venereology Task Force on QoL and Patient Oriented Outcomes and the Task Force on Acne, Rosacea and Hidradenitis Suppurativa have documented the QoL instruments that have been used in acne patients, with information on validation, purposes of their usage, description of common limitations and mistakes in their usage and overall recommendations.

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“…These features allow greater adherence to treatment associated with well-being and patient comfort. 25,27 Additional component of DRTW formulation is potassium azeloyl diglycinate (KAD) which is an ingredient obtained from the condensation of azelaic acid and glycine. These modifications in the molecule allow a better use of the pharmacological properties of azelaic acid, reducing the toxicological potential and increasing the stability and pharmacotechnical compatibility.…”

Section: ***mentioning

confidence: 99%

Modulation of skin androgenesis and sebum production by a dermocosmetic formulation

Crocco

Bonifácio²,

Facchini³

et al. 2020

J of Cosmetic Dermatology

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Sebaceous glands (SG) are localized almost on the entire surface of skin and present as primary function, the production and secretion of sebum. Sebum consists of a mixture of triglycerides, free fatty acids, cholesterol, and esters that perform protective functions in waterproofing, lubrication, protection against friction, transport of antioxidants, among others. 1-3 Sebaceous glands activity can be upregulated by many factors, particularly androgens. Dihydrotestosterone (DHT) is the androgen with the highest biological activity in tissue, being converted intracellularly from testosterone by the action of the 5α-reductase

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Assessment of the Efficacy and Safety of a Combination of 2 Topical Retinoids (RetinSphere) in Maintaining Post-Treatment Response of Acne to Oral Isotretinoin

Abstract: This new retinoid combination (Retinsphere technology) were effective and safe as maintenance therapy after post-treatment response to oral isotretinoin in patients with acne.

Cited by 5 publications

References 17 publications

Investigation of relapse rate and factors affecting relapse after oral isotretinoin treatment in patients with acne vulgaris

Investigation of relapse rate and factors affecting relapse after oral isotretinoin treatment in patients with acne vulgaris

Quality of life measurement in acne. Position Paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

Modulation of skin androgenesis and sebum production by a dermocosmetic formulation

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