Assessment of the efficacy and tolerance of a new combination of retinoids and depigmenting agents in the treatment of melasma

Abstract

Summary Background Melasma is a dermatosis with significant repercussions on patients' quality of life, and there is currently no standard treatment. Hydroquinone is deemed the treatment of choice, but its safety has been questioned in certain cases. Aims To determine the efficacy and safety of a new combination of retinoids in the improvement of melasma. Patients/Methods Prospective, double‐blind, vehicle‐controlled, and randomized study in 30 patients with melasma. The product was applied on one side of the face and the vehicle on the other, twice daily during 3 months. Standardized photographs were taken using RBX technology on the three visits (basal, at one and a half months and at 3 months). The main variable to determine the efficacy was the improvement of the hemifacial Melasma Area Severity Index (MASI). Other variables were determined such as improvement perceived by the investigator, improvement perceived by the patient, impact on quality of life or side effects. Results The MASI improvement at 3 months of treatment was significant on the treated side vs. the vehicle side, reaching an improvement of 70%, which is comparable to the percentage of improvement described with hydroquinone. No notable side effects were detected, in spite of a significant percentage of patients included in the study citing a history that could be compatible with sensitive skin. Conclusions This new combination of retinoids and depigmenting agents proved to be effective and safe in the treatment of melasma.

Histological and Immunohistochemical Evaluation of the Efficacy of a New Cosmetic Formulation in the Treatment of Skin Photoaging

“…Regarding the clinical assessments, there is a normal increase of melanin during photoaging, related to an excess of its production by senescent melanocytes. The use of retinoids (and in particular this combination of hydroxypinacolone retinoate with retinol glycospheres) has demonstrated the improvement of hyperpigmentation in previous studies and therefore it may be indicated for the treatment [ 25 ]. Even though a clinical improvement in the degree of pigmentation was achieved, an objective assessment to determine its precise scope is necessary.…”

Melasma: A Condition of Asian Skin

“…Truchuelo et al discussed a new formula called Neoretín® which encompasses retinoids including retinol glycospheres and hydroxypinacolone retinoate and depigmenting agents has demonstrated success in treating melasma-like hyperpigmentation. Patients’ hyperpigmented spots were reduced in 89% of the treated area while only 56% of the area showed some improvement in the control group who received a vehicle formulation (p<0.001) [ 47 ]. Neoretín® was also well-tolerated except for a few patients who reported intense pruritis, burning sensation, and erythema [ 47 ].…”

“…Patients’ hyperpigmented spots were reduced in 89% of the treated area while only 56% of the area showed some improvement in the control group who received a vehicle formulation (p<0.001) [ 47 ]. Neoretín® was also well-tolerated except for a few patients who reported intense pruritis, burning sensation, and erythema [ 47 ].…”

Safety and Efficacy of a New Regimen in Homogenizing and Brightening Skin Complexion Among Filipino Women

“…One of them is Retinsphere®Technology, a combination of two retinoids ( retinol glycospheres and hydroxipinacolone retinoate), is formulated in a moisturizing system to reduce Transepidermal Water Loss (TEWL). This ingredient has proven lightening activity acting on the regulatory mechanisms of melanogenesis, acceleration of epidermal turnover and facilitating the penetration of other depigmenting agents included in the formula (Neoretin® Discrom control) [8]. This formula has demonstrated its efficacy, tolerability and safety in several previous studies [8][9][10].…”

“…This ingredient has proven lightening activity acting on the regulatory mechanisms of melanogenesis, acceleration of epidermal turnover and facilitating the penetration of other depigmenting agents included in the formula (Neoretin® Discrom control) [8]. This formula has demonstrated its efficacy, tolerability and safety in several previous studies [8][9][10].…”