Assessment of the Efficacy of the Bio-Absorbable Oxidized Regenerated Cellulose for Prevention of Post-Operative Pericardial Adhesion in the Rabbit Model

Biçer, Murat; Bayram, A. S.; Gürbüz, Orçun; Şenkaya, İşık; Yerci, Ömer; Tok, Mustafa; Ang, E. S.; Moğol, EB; Saba, Davit

doi:10.1177/147323000803600619

Cited by 18 publications

(13 citation statements)

References 24 publications

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“…Nevertheless, while recurrence rates of around 10 % were seen in the PGA/TC cases, no postoperative recurrence was observed in the ROCM series. A recent animal study revealed that covering tissue with ROCM prevents a long-term foreign body reaction and the development of adhesions at the surgical site, and also increases mesothelium-like cell proliferation [5]. These results suggest that ROCM may prevent pleural adhesions and strengthen the visceral pleura by increasing its thickness [6].…”

Section: Discussionmentioning

confidence: 99%

What is an appropriate material to use with a covering technique to prevent the recurrence of spontaneous pneumothorax?

Uramoto

Tanaka

2014

J Cardiothorac Surg

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BackgroundThe purpose of this retrospective study was to identify an appropriate material that can be used as a covering for patients with a spontaneous pneumothorax (SP). A total of 279 patients were studied over a period of eight years.MethodsThe patient characteristics, surgical details and perioperative outcomes were analyzed. We compared the clinicopathological characteristics between recurrent and non-recurrent cases, and examined the associations with the material used for covering the SP, such as polyglycolic acid (PGA) sheets, a fibrinogen-based collagen fleece (TachoComb; TC) or regenerated oxidized cellulose mesh (ROCM).ResultsThe differences in the gender, smoking habits, lesion site, location, comorbidities, ipsilateral spontaneous pneumothorax (ISP), contralateral spontaneous pneumothorax (CSP) and surgery for ISP did not reach statistical significance between the patients treated with a covering of ROCM and those treated with PGA/TC, although the age of the patients was significantly different in these groups, with the ROCM group having younger patients (p = 0.024). The length of the operation was significantly shorter in the ROCM group (mean: 76.7 minutes) than in the PGA/TC cases (130.4 minutes, p = 0.015). Concerning the intraoperative factors, there were no significant differences with regard to the approach, buttress stapling, covering or surgeon. No postoperative recurrence was observed in this series. There were no significant differences in the perioperative outcomes. However, the drainage period was shorter in subjects who underwent covering with the ROCM (mean: 1.125 days) than with the PGA/TC (2.412 days, p = 0.030). Further, the hospital stay had a tendency to be shorter in subjects who underwent covering with ROCM than with PGA/TC.ConclusionsROCM might be superior to PGA/TC as a material for covering SP in terms of the length of the operation and the drainage period. ROCM might decrease the hospital stay and the postoperative recurrence. Prospective studies in a larger cohort of patients will be necessary to define the optimal surgical technique to suppress the recurrence of SP.

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Section: Discussionmentioning

confidence: 99%

What is an appropriate material to use with a covering technique to prevent the recurrence of spontaneous pneumothorax?

Uramoto

Tanaka

2014

J Cardiothorac Surg

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“…reported that ORC's efficacy in a postoperative pericardial adhesion model of New Zealand white rabbit. [ 121 ] Various other studies also suggested that Interceed helps prevent adhesion in an intraabdominal wall and uterus abrasion rabbit model compared with the control group, while it showed less efficacy in adhesion prevention than the HA/sodium alginate‐based microparticle antiadhesion agents. [ 122 ] In addition to a number of animal studies that suggested that the important role of Interceed [ 123,124 ] and several clinical trials further proved adhesion prevention efficacy.…”

Section: Biomaterials To Fabricate Antiadhesion Barriersmentioning

confidence: 99%

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Chandel

Shimizu

Hasegawa

et al. 2021

Macromolecular Bioscience

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Postoperative peritoneal adhesion (PPA) is a prevalent incidence that generally happens during the healing process of traumatized tissues. It causes multiple severe complications such as intestinal obstruction, chronic abdominal pain, and female infertility. To prevent PPA, several antiadhesion materials and drug delivery systems composed of biomaterials are used clinically, and clinical antiadhesive is one of the important applications nowadays. In addition to several commercially available materials, like film, spray, injectable hydrogel, powder, or solution type have been energetically studied based on natural and synthetic biomaterials such as alginate, hyaluronan, cellulose, starch, chondroitin sulfate, polyethylene glycol, polylactic acid, etc. Moreover, many kinds of animal adhesion models, such as cecum abrasion models and unitary horn models, are developed to evaluate new materials’ efficacy. A new animal adhesion model based on hepatectomy and conventional animal adhesion models is recently developed and a new adhesion barrier by this new model is also developed. In summary, many kinds of materials and animal models are studied; thus, it is quite important to overview this field's current progress. Here, PPA is reviewed in terms of the species of biomaterials and animal models and several problems to be solved to develop better antiadhesion materials in the future are discussed.

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“…Interceed has been studied in animal models in combination with heparin and has been shown to significantly reduce adhesion formation in rabbit uterine horn [240,241] and pericardium [242]. Similarly, other human trials generally find that Interceed reduces the severity, extent, and/or incidence of pelvic adhesions [243][244][245][246][247][248].…”

Section: Cellulose Based Barriersmentioning

confidence: 99%

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

et al. 2021

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Post-operative adhesions affect patients undergoing all types of surgeries. They are associated with serious complications, including higher risk of morbidity and mortality. Given increased hospitalization, longer operative times, and longer length of hospital stay, post-surgical adhesions also pose a great financial burden. Although our knowledge of some of the underlying mechanisms driving adhesion formation has significantly improved over the past two decades, literature has yet to fully explain the pathogenesis and etiology of post-surgical adhesions. As a result, finding an ideal preventative strategy and leveraging appropriate tissue engineering strategies has proven to be difficult. Different products have been developed and enjoyed various levels of success along the translational tissue engineering research spectrum, but their clinical translation has been limited. Herein, we comprehensively review the agents and products that have been developed to mitigate post-operative adhesion formation. We also assess emerging strategies that aid in facilitating precision and personalized medicine to improve outcomes for patients and our healthcare system.

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Assessment of the Efficacy of the Bio-Absorbable Oxidized Regenerated Cellulose for Prevention of Post-Operative Pericardial Adhesion in the Rabbit Model

Cited by 18 publications

References 24 publications

What is an appropriate material to use with a covering technique to prevent the recurrence of spontaneous pneumothorax?

What is an appropriate material to use with a covering technique to prevent the recurrence of spontaneous pneumothorax?

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

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