Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches

Yang, Fangwei; Zhao, Gang; Ren, Fazheng; Pang, Guo‐Fang; Li, Yixuan

doi:10.1016/j.envint.2019.105383

Cited by 41 publications

(19 citation statements)

References 101 publications

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“…In models that incorporated the measured change in metabolite levels and covariates, we did not find a significant relationship for TDEP. However, a study of chronic DEP exposure of rats compared with a control group resulted in a significant decrease in serum TSH and FT3, but T3 and FT4 levels increased significantly in a dosedependent manner [7].…”

Section: Changes In Thyroid Hormone Levels After Sprayingmentioning

confidence: 94%

“…Currently, OPs remain one of the most commonly used pesticides [7]. Several epidemiologic studies have established an association between OPs and alterations of thyroid hormone levels [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Experimental animal studies have also shown that organophosphate (OP) disturb thyroid gland function [15,16]. Whether the thyroid effects are caused by the parent OPs or the DAP metabolites is not known [7]. When humans are exposed to the OP, it is metabolized into the specific metabolite 3,5,6-trichloro-2-pyridinol (TCP) and the nonspecific OP metabolites diethyl phosphate (DEP) and diethyl thiophosphate (DETP) [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Acute Changes in Thyroid Hormone Levels among Thai Pesticide Sprayers

Kongtip

Nankongnab

Pundee

et al. 2021

Toxics

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The objective of this study was to investigate the relationship of acute pesticide exposures and acute changes in thyroid hormones among Thai farmers. We recruited 78 farmers, who were scheduled to spray insecticides (chlorpyrifos and/or cypermethrin) or herbicides (paraquat and/or glyphosate). On the day before spraying, farmers collected their first morning void urine and went for blood collection. On the spray day, urine samples were collected at end of the spraying event and they were interviewed with questionnaires. The next morning, the first morning void urine and blood samples were collected. Blood samples were analyzed for thyroid hormones. Urine samples were analyzed for the metabolites of the pesticide sprayed. The results showed that the thyroid hormones, free triiodothyronine (FT3) and total triiodothyronine (T3) were significantly reduced as urinary chlorpyrifos metabolite increased the day after spraying. Total thyroxine (T4) significantly increased as cypermethrin metabolites increased the day after spraying. T4 significantly increased as urinary glyphosate levels increased; however, FT3 and T3 decreased significantly as urinary paraquat levels increased the day after spraying. These findings suggest that acute exposures to the pesticides chlorpyrifos, cypermethrin, paraquat and glyphosate can produce acute effects on the hypothalamic–pituitary–thyroid (HPT) axis, acutely altering thyroid hormone levels.

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Section: Changes In Thyroid Hormone Levels After Sprayingmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Changes in Thyroid Hormone Levels among Thai Pesticide Sprayers

Kongtip

Nankongnab

Pundee

et al. 2021

Toxics

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“…Exposures to OP compounds also continue to be implicated in the etiology of various conditions for which solid research is needed to resolve issues of causation vs. correlation amid complexity and controversy. These disorders include aerotoxic syndrome (Carletti et al, 2011;Hageman et al, 2019), Gulf War Illness (Michalovicz et al, 2019), thyroid and other endocrine disruptions (Yang et al, 2020), and Type 2 diabetes and obesity (Czajka et al, 2019). However, arguably the most compelling justifications for NTE research are embodied in the intriguing scientific questions concerning the mechanisms of axonal degeneration following changes in the structure and/or function of NTE brought about by chemical exposures and/or genetic mutations (Hufnagel et al, 2015;Kmoch et al, 2015;Read et al, 2009;Richardson et al, 2013;Sunderhaus et al, 2019a,b).…”

Section: Rationale For Nte Researchmentioning

confidence: 99%

Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN)

Richardson

Fink

Glynn

et al. 2020

Advances in Neurotoxicology

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Structure-activity relationships (SARs) 35 7.3 Protection (prophylaxis) against OPIDN 36 7.4 Potentiation or promotion of OPIDN 38 7.5 NTE-based biomarkers and biosensors 39 8. Cellular and molecular biology of NTE 40 8.1 NTE: The next generation 40 8.2 NTE protein sequences and domains 40 8.3 Subcellular localization of NTE 46 8.4 Expression of NTE in human tissues 46 8.5 NTE knockouts, silencing, and mutations 47 9. Reconciling apparent conflicts between toxicological and genetic data 50 10. Suggested future research on elucidating the role of NTE in OPIDN 53 10.1 Phospholipid homeostasis disruption (PHD) 54 10.2 OP-induced Wallerian degeneration (OPIWAD) 56 11. Conclusion 60 References 61

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“…Commonly used pesticides acting as EDCs include organophosphorus pesticides (OPPs), organochlorine pesticides (OCPs) and herbicides such as chlorotriazine (CTs) and glyphosate [37]. OPPs are widely employed in agriculture (e.g., chlorpyrifos with 45,000 tons produced in 2016) and their residues in all food products and related environments need to be estimated in order to assess the risks of human exposure [38]. Atrazine is one of the most popular CTs herbicides used for many years and, together with other dangerous EDCs (equally banned in most countries) is again detected in surface and underground water all over the world [39].…”

Section: Introductionmentioning

confidence: 99%

Endocrine-Disrupting Compounds: An Overview on Their Occurrence in the Aquatic Environment and Human Exposure

Pironti

Ricciardi

Proto

et al. 2021

Water

141

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Endocrine-disrupting compounds (EDCs) as emerging contaminants have accumulated in the aquatic environment at concentration levels that have been determined to be significant to humans and animals. Several compounds belong to this family, from natural substances (hormones such as estrone, 17β-estradiol, and estriol) to synthetic chemicals, especially pesticides, pharmaceuticals, and plastic-derived compounds (phthalates, bisphenol A). In this review, we discuss recent works regarding EDC occurrence in the aquatic compartment, strengths and limitations of current analytical methods used for their detection, treatment technologies for their removal from water, and the health issues that they can trigger in humans. Nowadays, many EDCs have been identified in significant amounts in different water matrices including drinking water, thus increasing the possibility of entering the food chain. Several studies correlate human exposure to high concentrations of EDCs with serious effects such as infertility, thyroid dysfunction, early puberty, endometriosis, diabetes, and obesity. Although our intention is not to explain all disorders related to EDCs exposure, this review aims to guide future research towards a deeper knowledge of EDCs’ contamination and accumulation in water, highlighting their toxicity and exposure risks to humans.

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Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches

Cited by 41 publications

References 101 publications

Acute Changes in Thyroid Hormone Levels among Thai Pesticide Sprayers

Acute Changes in Thyroid Hormone Levels among Thai Pesticide Sprayers

Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN)

Endocrine-Disrupting Compounds: An Overview on Their Occurrence in the Aquatic Environment and Human Exposure

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