Assessment of the female fetal DNA concentration in the plasma of the pregnant women as preeclampsia indicator—Preliminary report

Engel, Karina; Płonka, Tomasz; Bilar, Marek; Orzińska, Agnieszka; Brojer, Ewa; Elżbieta, Ronin-Walkowska

doi:10.1016/j.ejogrb.2009.06.016

Cited by 6 publications

(2 citation statements)

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“…A total of 52 articles were identified using the search criteria. Twenty‐six were excluded because of evaluation of cffDNA after the diagnosis of preeclampsia had been established . Four abstracts were excluded, leaving 22 articles eligible for full‐text review.…”

Section: Resultsmentioning

confidence: 99%

Can the quantity of cell‐free fetal DNA predict preeclampsia: a systematic review

et al. 2014

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Section: Resultsmentioning

confidence: 99%

Can the quantity of cell‐free fetal DNA predict preeclampsia: a systematic review

et al. 2014

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“…Therefore, early prediction of eclampsia and active preventive measures will help improve the prognosis of mothers and infants. At present, many scholars have put forth a number of different forecasting methods, including early villi special genetic testing, uterine artery Doppler, maternal peripheral blood fetal DNA enrichment, etc [20][21][22][23]. However, the predictive values of the above methods are quite different.…”

Section: The Predictive Value Of Maternal Serum Tbx2 Levels For Preecmentioning

confidence: 99%

Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Xia

Wang

et al. 2010

Front. Med. China

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This study was aimed to detect maternal serum levels of thromboxane B2 (TXB2) in different durations of pregnancy and explore the predictive value of TXB2 for preeclampsia. By employing a prospective and doubleblind study method, 180 pregnant women with previously normal blood pressures during their progestation were included in the study. Peripheral venous blood samples were obtained during 10 + 0 -14 + 6 (period I), 20 + 0 -24 + 6 (period II) and 30 + 0 -34 + 6 (period III) weeks of gestation. Maternal serum levels of TXB2 were measured by enzyme-linked immunoassay. The pathogenetic condition and pregnancy outcomes of these cases were observed. (1) Among the 180 previously normotensive women, ten developed preeclampsia (case group; four severe and six mild preeclampsia). One hundred and seventy remained normal till the end of pregnancy (control group). (2) With development of pregnancy, the levels of maternal serum TXB2 in the 180 cases gradually ascended as seen through the Wilcoxon Signed Ranks Test. There was a statistical significance in maternal TXB2 levels between two different gestational stages (P < 0.01). (3) The levels of maternal serum TXB2 were slightly higher in the case group than in the control group during period I of gestation, but the difference was not statistically significant (P > 0.05); the levels of TXB2 were significantly higher in the case group than in the control group during periods II and III of gestation (both P < 0.05). (3) The best cutoff points of maternal TXB2 were 3750 and 4400 ng/mL during periods II and III of gestation by receiver operator characteristic (ROC) curve; and the sensitivity, specificity, positive predictive value, negative predictive value and odds radio of TXB2 in predicting preeclampsia were 80%, 69.5%, 13.3%, 98. 33%, 9.11 and 90%, 68.82%, 13.84%, 99.13, 19.86, respectively. Higher levels of maternal serum TXB2 were detected a long time before clinical symptoms appeared. The maternal serum TXB2 after 20 weeks of gestation had predictive value, and the index after 30 weeks was superior to that prior to 30 weeks .

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Circulating Nucleic Acids in Maternal Plasma and Serum in Pregnancy Complications: Are They Really Useful in Clinical Practice? A Systematic Review

et al. 2020

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Assessment of the female fetal DNA concentration in the plasma of the pregnant women as preeclampsia indicator—Preliminary report

Cited by 6 publications

References 25 publications

Can the quantity of cell‐free fetal DNA predict preeclampsia: a systematic review

Can the quantity of cell‐free fetal DNA predict preeclampsia: a systematic review

Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Circulating Nucleic Acids in Maternal Plasma and Serum in Pregnancy Complications: Are They Really Useful in Clinical Practice? A Systematic Review

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